A5100432574- Autophagy in Disease and Therapy
- Epigenetics and DNA Methylation
- Ubiquitin and proteasome pathways
- Hepatitis B Virus Studies
- Sirtuins and Resveratrol in Medicine
- Plant Pathogens and Fungal Diseases
- Influenza Virus Research Studies
- Hepatitis C virus research
- Microtubule and mitosis dynamics
- RNA modifications and cancer
- Supply Chain and Inventory Management
- Diabetes Management and Education
- Nuclear Structure and Function
- Cancer-related Molecular Pathways
- Galectins and Cancer Biology
- Cellular Mechanics and Interactions
- RNA Research and Splicing
- Caveolin-1 and cellular processes
- Mitochondrial Function and Pathology
- Gastric Cancer Management and Outcomes
- Sustainable Supply Chain Management
- Metabolism, Diabetes, and Cancer
- Mycorrhizal Fungi and Plant Interactions
- Histone Deacetylase Inhibitors Research
- Ophthalmology and Visual Impairment Studies
Peking University
2023-2025
Case Western Reserve University
2025
Fudan University Shanghai Cancer Center
2025
Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences
2024
Guiyang Medical University
2024
Shanghai Jiao Tong University
2015-2024
Shenzhen University Health Science Center
2018-2024
Northeast Normal University
2023-2024
Xi'an Jiaotong University
2021-2024
First Affiliated Hospital of Anhui Medical University
2024
A well defined cost function is crucial to steganography under the scenario of minimizing embedding distortion. In this paper, we present a new for spatial image steganography. The proposed designed by using high-pass filter locate less predictable parts in an image, and then two low-pass filters make low values more clustered. Experiments show that steganographic method with makes changes concentrated texture regions, thus achieves better performance on resisting state-of-the-art...
Mitochondria play a crucial role in tubular injury diabetic kidney disease (DKD). MitoQ is mitochondria-targeted antioxidant that exerts protective effects mice, but the mechanism underlying these not clear. We demonstrated mitochondrial abnormalities, such as defective mitophagy, reactive oxygen species (ROS) overexpression and fragmentation, occurred cells of db/db accompanied by reduced PINK Parkin expression increased apoptosis. These changes were partially reversed following an...
The ribosome is indispensable for precisely controlling the capacity of protein synthesis. However, how translational machinery coordinated to meet demands remains elusive. Here, we identify a nucleolar-specific lncRNA (LoNA), its 5' portion binds and sequesters nucleolin suppress rRNA transcription, snoRNA like 3' end recruits diminishes fibrillarin activity reduce methylation. Activity-dependent decrease LoNA leads elevated levels, an increased proportion polysomes, mRNA polysome loading,...
Abstract NAD+-dependent SIRT7 deacylase plays essential roles in ribosome biogenesis, stress response, genome integrity, metabolism and aging, while how it is transcriptionally regulated still largely unclear. TGF-β signaling highly conserved multicellular organisms, regulating cell growth, cancer stemness, migration invasion. Here, we demonstrate that histone deacetylase HDAC8 forms complex with SMAD3/4 heterotrimer occupies promoter, wherein deacetylates H4 thus suppresses transcription....
Abstract Rivaling the Himalaya in relief, Longmen Shan is probably one of most enigmatic mountain ranges world: high mountains reach more than 4000 m relief but without adjacent foreland subsidence and with only slow active convergence. What are geological geodynamic processes that built Shan? Coseismic deformation associated 2008 Wenchuan earthquake could hold clues to answer these questions. The primary features rupture have been narrowly distributed coseismic predominantly vertical...
DNA damage accumulates with age (Lombard et al., 2005). However, whether and how robust repair machinery promotes longevity is elusive. Here, we demonstrate that ATM-centered response (DDR) progressively declines senescence age, while low dose of chloroquine (CQ) activates ATM, clearance, rescues age-related metabolic shift, prolongs replicative lifespan. Molecularly, ATM phosphorylates SIRT6 deacetylase thus prevents MDM2-mediated ubiquitination proteasomal degradation. Extra copies Sirt6...
Hair follicle stem cells (HFSCs) are maintained in a quiescent state until activated to grow, but the mechanisms that reactivate HFSC reservoir unclear. Here, we find loss of Sirt7 mice impedes hair life-cycle transition from telogen anagen phase, resulting delay growth. Conversely, overexpression during phase facilitated HSFC entry and accelerated Mechanistically, is upregulated HFSCs telogen-to-anagen transition, HFSC-specific knockout (Sirt7f/f ;K15-Cre) exhibit similar growth delay. At...
The NAD+-dependent deacetylase Sirt1 has been implicated in the prevention of many age-related diseases, including cancer, type 2 diabetes, and cardiovascular disease. Resveratrol, a plant polyphenol, exhibits antiaging, antitumor, vascular protection effects by activating Sirt1. However, molecular mechanism activation as induced resveratrol remains unclear. By knockdown/rescue experiments, fluorometric activity assay, immunoprecipitation, pull-down assays, we identify here that tumor...
Colorectal cancer (CRC) seriously endangers human health owing to its high morbidity and mortality.Previous studies have suggested that expression of CBX2 may be associated with poor prognosis in CRC patients.However, functional role remains elucidated.Herein, we found overexpression colorectal tissue compared adjacent tissues.Additionally, forest maps the nomogram model indicated elevated was an independent prognostic factor CRC.Moreover, confirmed deletion markedly suppressed proliferation...
Beyond the antimicrobial activity, doxycycline (DOX) exhibits longevity-promoting effect in nematodes, while its on mammals is unclear. Here, we applied a mouse model of Hutchinson-Gilford progeria syndrome (HGPS), Zmpste24 knockout (KO) mice, and analyzed antiaging DOX. We found that DOX treatment prolongs lifespan ameliorates progeroid features KO including decline body tissue weight, exercise capacity cortical bone density, shortened colon length. alleviates abnormal nuclear envelope...
The dental pulp stem cells (DPSCs) are a population of mesenchymal cells, which have multilineage potential and high proliferation. DPSCs regarded as promising tool for tissue regeneration dentine, pulp, bone, cartilage, muscle. Recently, magnetic materials become commonly applied in clinics. Static field has been reported to regulate the proliferation, migration, or differentiation cells. However, whether static fields affect is still unknown. In our study, we investigated effect on DPSCs....
Abstract Though used widely in cancer therapy, paclitaxel only elicits a response fraction of patients. A strong determinant tumor is the state microtubule dynamic instability. However, whether manipulation this physiological process can be controlled to enhance has not been tested. Here, we show previously unrecognized role microtubule-associated protein CRMP2 inducing bundling through its carboxy terminus. This activity significantly decreased when FER tyrosine kinase phosphorylates at...
In a biological environment, nanoparticles encounter and interact with thousands of proteins, forming protein corona on the surface nanoparticles, but these interactions are oftentimes perceived as nonspecific adsorption, unfolding deactivation most likely consequences. The potential nanoparticle-protein interaction to mimic protein-protein in cellular signaling process, characterized by stringent binding specificity robust functional modulation for interacting protein, has not been...
Embryonic stem cells (ESCs) are pluripotent with the ability to self‐renew and differentiate into any cell types of 3 germ layers. Recent studies have demonstrated that there is a strong connection between mitochondrial function pluripotency. Here, we report methyltransferase like (Mettl) 17, identified from clustered regularly interspaced short palindromic repeats knockout screen, required for proper differentiation mouse embryonic (mESCs). Mettl17 located in mitochondria through its...
Abstract The progressive decline of physiological function and the increased risk age-related diseases challenge healthy aging. Multiple anti-aging manipulations, such as senolytics, have proven beneficial for health; however, biomarkers that label in vivo senescence at systemic levels are lacking, thus hindering applications. In this study, we generate a Glb1 +/m ‒Glb1-2A-mCherry (GAC) reporter allele gene locus, which encodes lysosomal β-galactosidase—an enzyme elevated tissues old mice. A...
To compare the accuracy of intraocular lens (IOL) power calculation methods for post-myopic excimer laser surgery patients without previous refractive data using Holladay IOL Consultant Program and American Society Cataract Refractive Surgery (ASCRS) Power Calculator.Wang Vision LASIK Center, Nashville, Tennessee, USA.Case series.Eight were used to calculate power: 2 partial coherence interferometry (PCI)-K, FlatK, Wang-Koch-Maloney, Shammas No-History, Haigis-L, ASCRS-Average, ASCRS-Min,...