A5067595997- Ovarian cancer diagnosis and treatment
- Monoclonal and Polyclonal Antibodies Research
- Cancer-related Molecular Pathways
- HER2/EGFR in Cancer Research
- Endometrial and Cervical Cancer Treatments
- Microtubule and mitosis dynamics
- Cancer-related molecular mechanisms research
- Autophagy in Disease and Therapy
- Cancer Genomics and Diagnostics
- PARP inhibition in cancer therapy
- Glycosylation and Glycoproteins Research
- Virus-based gene therapy research
- Cancer, Lipids, and Metabolism
- Genetic Syndromes and Imprinting
- Epigenetics and DNA Methylation
- Cancer Treatment and Pharmacology
- Cancer Research and Treatments
- Immunotherapy and Immune Responses
- Advanced Biosensing Techniques and Applications
- Cancer, Hypoxia, and Metabolism
- PI3K/AKT/mTOR signaling in cancer
- Cancer Cells and Metastasis
- Toxin Mechanisms and Immunotoxins
- Cancer Mechanisms and Therapy
- Reproductive System and Pregnancy
The University of Texas MD Anderson Cancer Center
2016-2025
John Wiley & Sons (United States)
2020
American University of Beirut
2020
Hudson Institute
2020
University of Houston
2010-2020
American Society of Clinical Oncology
2001-2017
Texas Oncology
2007-2017
Dana-Farber Cancer Institute
1979-2017
Baylor University Medical Center
2017
Case Western Reserve University
2016
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, on this topic has continued to accelerate, and many new scientists have entered field. Our knowledge base relevant technologies also been expanding. Accordingly, it is important update these monitoring autophagy different organisms. Various reviews described range assays that used purpose. Nevertheless, there continues be confusion regarding acceptable methods measure autophagy, especially...
The murine monoclonal antibody OC 125 reacts with an antigen (CA 125) common to most nonmucinous epithelial ovarian carcinomas. An assay has been developed detect CA in serum. By this assay, only 1 per cent of 888 apparently healthy persons and 6 143 patients nonmalignant disease had serum levels above 35 U milliliter. In contrast, 83 101 (82 cent) surgically demonstrated carcinoma elevated antigen. 38 monitored on 2 18 occasions during 60 months, ranged from less than more 8000 Rising or...
A murine monoclonal antibody (OC125) has been developed that reacts with each of six epithelial ovarian carcinoma cell lines and cryopreserved tumor tissue from 12 20 cancer patients. By contrast, the does not bind to a variety nonmalignant tissues, including adult fetal ovary. OC125 only 1 14 derived nonovarian neoplasms failed react cryostat sections carcinomas.
To update the recommendations for use of tumor marker tests in prevention, screening, treatment, and surveillance gastrointestinal cancers.For 2006 update, an committee composed members from full Panel was formed to complete review analysis data published since 1999. Computerized literature searches Medline Cochrane Collaboration Library were performed. The Update Committee's focused attention on available systematic reviews meta-analyses studies.For colorectal cancer, it is recommended that...
Updated National Academy of Clinical Biochemistry (NACB) Laboratory Medicine Practice Guidelines for the use tumor markers in clinic have been developed.Published reports relevant to 5 cancer sites--testicular, prostate, colorectal, breast, and ovarian--were critically reviewed.For testicular cancer, alpha-fetoprotein, human chorionic gonadotropin, lactate dehydrogenase are recommended diagnosis/case finding, staging, prognosis determination, recurrence detection, therapy monitoring....
Abstract Early detection remains the most promising approach to improve long-term survival of patients with ovarian cancer. In a five-center case-control study, serum proteomic expressions were analyzed on 153 invasive epithelial cancer, 42 other cancers, 166 benign pelvic masses, and 142 healthy women. Data from early stage cancer women at two centers independently results cross-validated discover potential biomarkers. The validated using samples remaining centers. After protein...
To update the 1997 clinical practice guidelines for use of tumor marker tests in prevention, screening, treatment, and surveillance breast colorectal cancers. These are intended care patients outside trials.Six markers cancer eight were considered. They could be recommended or not routine special circumstances. In addition to carcinoembryonic antigen (CEA) CA 15-3, 27.29 was also considered among serum cancer.In general, significant health outcomes identified making (overall survival,...
Glycogen synthase kinase 3 (GSK-3) is implicated in multiple biological processes including metabolism, gene expression, cell fate determination, proliferation, and survival. GSK-3 activity inhibited through phosphorylation of serine 21 GSK-3α 9 GSK-3β. These residues have been previously identified as targets protein B (PKB/Akt), a serine/threonine located downstream phosphatidylinositol 3-kinase. Here, we show that GSK-3β are also physiological substrates cAMP-dependent A. Protein A...
Original Article from The New England Journal of Medicine — Effect Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor on Hematopoietic Reconstitution after High-Dose Chemotherapy and Autologous Bone Marrow Transplantation
OC125, a murine monoclonal antibody, recognizes an antigenic determinant (CA125) that is associated with >80% of epithelial ovarian neoplasms serous, endometrioid, clear cell, and undifferentiated types. In the present report, sensitive biotin-avidin immunoperoxidase technique was used to determine reactivity OC125 normal adult fetal tissues, as well nonovarian origin. antibody reacted amnion derivatives coelomic epithelium, i.e., mül-lerian epithelium lining cells peritoneum, pleura,...
PURPOSE We studied high-dose cyclophosphamide, cisplatin, and carmustine (CPA/cDDP/BCNU) with autologous bone marrow support (ABMS) as consolidation after standard-dose adjuvant chemotherapy treatment of primary breast cancer involving 10 or more axillary lymph nodes. PATIENTS AND METHODS One hundred two women stage IIA, IIB, IIIA, IIIB nodes at surgery were registered; 85 eligible, treated, assessable. Patients treated four cycles doxorubicin, fluorouracil (CAF), followed by CPA/cDDP/BCNU...
The role of autophagy in oncogenesis remains ambiguous, and mechanisms that induce regulate its outcome human cancers are poorly understood. maternally imprinted Ras-related tumor suppressor gene aplasia Ras homolog member I (ARHI; also known as DIRAS3) is downregulated more than 60% ovarian cancers, here we show re-expression ARHI multiple cancer cell lines induces by blocking PI3K signaling inhibiting mammalian target rapamycin (mTOR), upregulating ATG4, colocalizing with cleaved...