A5100712941- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Disease and Adiposity
- Acute Myeloid Leukemia Research
- Cancer, Lipids, and Metabolism
- Chronic Myeloid Leukemia Treatments
- Cardiovascular Function and Risk Factors
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Colorectal Cancer Treatments and Studies
- Lung Cancer Diagnosis and Treatment
- Histone Deacetylase Inhibitors Research
- Stress Responses and Cortisol
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Bone Metabolism and Diseases
- Acupuncture Treatment Research Studies
- Epigenetics and DNA Methylation
- Genetic factors in colorectal cancer
- Obesity, Physical Activity, Diet
- Lung Cancer Research Studies
- Liver Disease Diagnosis and Treatment
- Molecular Biology Techniques and Applications
- Pediatric Urology and Nephrology Studies
- HIV-related health complications and treatments
Southwest University
2025
Gansu University of Traditional Chinese Medicine
2022-2025
First Hospital of Shanxi Medical University
2021-2025
Shanxi Medical University
2015-2025
Xinxiang Medical University
2022-2025
University of Electronic Science and Technology of China
2025
Beijing VDJBio (China)
2024-2025
Guilin University of Technology
2025
Hangzhou Center for Disease Control and Prevention
2011-2024
West China Hospital of Sichuan University
2022-2024
The role of autophagy in oncogenesis remains ambiguous, and mechanisms that induce regulate its outcome human cancers are poorly understood. maternally imprinted Ras-related tumor suppressor gene aplasia Ras homolog member I (ARHI; also known as DIRAS3) is downregulated more than 60% ovarian cancers, here we show re-expression ARHI multiple cancer cell lines induces by blocking PI3K signaling inhibiting mammalian target rapamycin (mTOR), upregulating ATG4, colocalizing with cleaved...
NF-κB-mediated inflammatory phenotypic switching of vascular smooth muscle cells (VSMCs) plays a central role in atherosclerosis and neointimal formation. However, little is known about the roles circRNAs regulation NF-κB signaling. Here, we identify involvement circ-Sirt1 that was one transcripts SIRT1 host gene VSMC response hyperplasia. First, cytoplasm, directly interacts with sequesters p65 from nuclear translocation induced by TNF-α sequence-dependent manner. The inhibitory complex...
Occupational exposure to chromium compounds may result in adverse health effects. This study aims investigate whether low-level hexavalent (Cr(VI)) can cause DNA damage electroplating workers.157 workers and 93 control subjects with no history of occupational were recruited Hangzhou, China. Chromium levels erythrocytes determined by graphite furnace atomic absorption spectrophotometer. peripheral lymphocytes was evaluated the alkaline comet assay three parameters: Olive tail moment, length...
Abstract Background Multiple myeloma (MM) is a B-cell malignancy that largely incurable and characterized by the accumulation of malignant plasma cells in bone marrow. Apigenin, common flavonoid, has been reported to suppress proliferation wide variety solid tumors hematological cancers; however its mechanism not well understood effect on MM determined. Results In this study, we investigated effects apigenin cell lines primary cells. Cell viability assays demonstrated exhibited cytotoxicity...
Abstract Background Celastrol is an active ingredient of the traditional Chinese medicinal plant Tripterygium Wilfordii , which exhibits significant antitumor activity in different cancer models vitro and vivo ; however, lack information on target mechanism action this compound have impeded its clinical application. In study, we sought to determine mode celastrol by focusing processes that mediate anticancer activity. Methods The downregulation heat shock protein 90 (HSP90) client proteins,...
Hypertension is the primary out-auditory adverse outcome caused due to occupational noise exposure. This study investigated associations of exposure in an setting with blood pressure and risk hypertension. A total 1,390 noise-exposed workers 1399 frequency matched non-noise-exposed subjects were recruited from a cross-sectional survey general population, respectively. Blood was measured using mercury sphygmomanometer following standard protocol. Multiple logistic regression used calculate...
Abstract Background There is metabolic heterogeneity in normal-weight individuals, however, there has been limited research the Chinese population. This study aimed to investigate prevalence, distribution and epidemiological determinants of metabolically obese but (MONW) a Methods A total 17,876 individuals were recruited from 37,815 Zhejiang province southeastern China. Normal-weight was defined as body mass index (BMI) 18.5–23.9 kg/m 2 . Metabolically abnormal traits assessed by syndrome...
Metabolic syndrome (MetS) is a cluster of multiple cardiometabolic risk factors that increase the type 2 diabetes and cardiovascular diseases. Identifying novel biomarkers MetS their genetic associations could provide insights into mechanisms diseases.Potential MetS-associated metabolites were screened internally validated by untargeted metabolomics analyses among 693 patients with 705 controls. External validation was conducted using two well-established targeted metabolomic methods 149 253...
Research on glucosamine shows anti-inflammatory and anti-cancer benefits with minimal adverse effects. We aimed to explore the relationship between use of risk lung cancer mortality based data from large-scale nationwide prospective UK Biobank cohort study.Participants were enrolled 2006 2010 followed-up 2020. The Cox proportional hazards model was used assess mortality. Subgroup analyses sensitivity performed potential effect modifications robustness main findings.439 393 participants (mean...
Protein kinase A (PKA)/cAMP response element-binding (CREB) protein signaling pathway, contributing to impaired neurogenesis parallel depressive-like behaviors, has been identified as the crucial factor involved in antidepressant of acupuncture. However, molecular mechanisms associated with acupuncture, neurogenesis, and behaviors ameliorating remain unexplored. The objective was identify underlying acupuncture through PKA pathway depression rats by employing inhibitor H89 vivo experiments....
Sensitive and stable biomarkers that facilitate depression detection monitor the antidepressant efficiency are currently unavailable. Thus, objective is to investigate potential of DNA methylation histone modifications brain-derived neurotrophic factor (BDNF) in monitoring severity antidepressive effects acupuncture. The rat model was imitated by social isolation chronic unpredicted mild stress (CUMS). expression serum BDNF detected ELISA, hippocampal BDNF, acH3K9 HDAC2 WB, mRNA RT-PCR....
The potential distribution of the invasive plant Anredera cordifolia (Tenore) Steenis was predicted by Random Forest models under current and future climate-change pathways (i.e., RCP4.5 RCP8.5 2050s 2070s). Pearson correlations were used to select variables; prediction accuracy evaluated using AUC, Kappa, TSS. results show that suitable areas are mainly in Southeast Asia, Eastern Oceania, a few parts Africa, Southern North America, South America. Temperature is key climatic factor affecting...
Analysis of biopsies from a recent clinical trial suggested that Depsipeptide FK228 (DP) inhibits Aurora kinase expression in lung cancer cells. The present study was undertaken to confirm and extend these observations.Aurora A B mRNA levels cells were considerably higher than normal pulmonary epithelia. DP, TSA SAHA inhibited A, survivin with kinetics remarkably similar within individual cell lines, appeared coincide p53 status. These effects not observed following treatment geldanamycins....
The objective of this study is to investigate the expression and distribution heat shock protein 70 (Hsp70) in intestine intrauterine growth retardation (IUGR) piglets. Samples from duodenum, prejejunum, distal jejunum, ileum, colon IUGR normal-body-weight (NBW) piglets were collected at birth. results indicated that body weight significantly lower than NBW villus height villus/crypt ratio jejunum ileum reduced compared These causes abnormal gastrointestinal morphologies dysfunction. mRNA...