A5003733739- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Lipid metabolism and biosynthesis
- High Altitude and Hypoxia
- Cholesterol and Lipid Metabolism
- Metabolomics and Mass Spectrometry Studies
- Immune cells in cancer
- Cancer, Stress, Anesthesia, and Immune Response
- Neuroinflammation and Neurodegeneration Mechanisms
- Atherosclerosis and Cardiovascular Diseases
- Natural product bioactivities and synthesis
- Adipose Tissue and Metabolism
- Pluripotent Stem Cells Research
- Mitochondrial Function and Pathology
- Ubiquitin and proteasome pathways
- Hormonal Regulation and Hypertension
- Signaling Pathways in Disease
- Inflammatory Bowel Disease
- Immune Response and Inflammation
- RNA Research and Splicing
- Neuroscience of respiration and sleep
- Animal Genetics and Reproduction
- MicroRNA in disease regulation
- CRISPR and Genetic Engineering
- RNA modifications and cancer
Kunming University of Science and Technology
2018-2025
First Affiliated Hospital of Zhengzhou University
2022-2025
University of Chinese Academy of Sciences
2025
Center for Excellence in Molecular Plant Sciences
2023-2025
Chinese Academy of Sciences
2023-2025
Union Hospital
2005-2024
Huazhong University of Science and Technology
2005-2024
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2011-2024
The Ohio State University
2015-2024
Second Xiangya Hospital of Central South University
2022-2024
Elevated lipogenesis regulated by sterol regulatory element-binding protein-1 (SREBP-1), a transcription factor playing central role in lipid metabolism, is novel characteristic of glioblastoma (GBM). The aim this study was to identify effective approaches suppress GBM growth inhibition SREBP-1. As SREBP activation negatively endoplasmic reticulum (ER) cholesterol, we sought determine whether suppression O-acyltransferase (SOAT), key enzyme converting ER cholesterol esters (CE) store...
The potential risk of a nanoparticle as medical application has raised wide concerns, and this study aims to investigate silver (AgNP)-induced acute toxicities, genotoxicities, target organs the underlying mechanisms.Sprague-Dawley rats were randomly divided into 4 groups (n = each group), AgNP (containing Ag nanoparticles released Ag+, 5 mg/kg), Ag+ (released from same dose AgNP, 0.0003 5% sucrose solution (vechicle control) cyclophophamide (positive control, 40 mg/kg) administrated...
Background: Intervertebral disc (IVD) degeneration is a common degenerative disease that can lead to collapse or herniation of the nucleus pulposus (NP) and result in radiculopathy patients. Methods: NP tissue cells were isolated from patients mice, expression profile cortistatin (CST) was analysed. In addition, ageing compared between 6-month-old WT CST-knockout (CST-/-) mice. Furthermore, tissues cultured validate role CST TNF-α-induced IVD degeneration. Moreover, vitro vivo experiments...
Abstract Numerous studies have indicated that primary tumors induce the formation of a pre‐metastatic niche in distant organs by secreting tumor‐derived factors. The present study shows pre‐exposure to chronic stress enhanced lung colonization efficiency circulating tumor cells, suggesting critically influences lungs before arrival disseminated cells. Ablation sympathetic nerve function 6‐OHDA or blockage β‐adrenergic signaling propranolol remarkably suppressed stress‐induced metastasis....
Recently, lipid metabolism reprogramming has been further evidenced in malignancies via the observation of large amounts droplets (LDs) human tumors, including glioblastoma (GBM), most lethal primary brain tumor. However, role played by LDs tumor cells remains unknown. Here, we show that triglycerides (TG), major components LDs, serve as a critical energy reservoir to support GBM cell survival. TG/LDs rapidly diminished upon glucose reduction, whereas inhibiting fatty acid oxidation or...
Abstract Mitophagy is an important metabolic mechanism that modulates mitochondrial quality and quantity by selectively removing damaged or unwanted mitochondria. BNIP3 (BCL2/adenovirus e1B 19 kDa protein interacting 3), a outer membrane protein, mitophagy receptor mediates under various stresses, particularly hypoxia, since hypoxia-responsive protein. However, the underlying mechanisms regulate thus mediate hypoxic conditions remain elusive. Here, we demonstrate in hypoxia JNK1/2 (c-Jun...
Background: Osteoarthritis (OA) is a degenerative disease which serious affects patients. Ligusticum chuanxiong (CX) has been shown to have certain curative effect on osteoarthritis in traditional Chinese medicine therapy. This study based network pharmacology and molecular docking technology explore the potential mechanism of CX. Methods: Components CX treat were screened TCMSP database targets predicted by PharmMapper database, collected from GeneCards intersection genes found be possible...
Hydrogel products for chronic diabetic wounds, a serious and prevalent complication of diabetes, show limited effects on disability remain nonspecific. Thus, improvements in the usage pharmaceutical molecule hydrogels are highly desirable to increase therapeutic effect hydrogels. In this study, thioctic acid (a common medicine diabetes treatment) is used preparing regenerative antibacterial (RAH) which contains situ synthesized silver nanoparticles (AgNPs). The RAH shows regenerative,...
Abstract Background Celastrol is an active ingredient of the traditional Chinese medicinal plant Tripterygium Wilfordii , which exhibits significant antitumor activity in different cancer models vitro and vivo ; however, lack information on target mechanism action this compound have impeded its clinical application. In study, we sought to determine mode celastrol by focusing processes that mediate anticancer activity. Methods The downregulation heat shock protein 90 (HSP90) client proteins,...
Dysregulated lipid metabolism is a characteristic of malignancies. Sterol regulatory element binding protein 1 (SREBP-1), transcription factor playing central role in metabolism, highly activated Here, we unraveled link between miR-29 and the SCAP (SREBP cleavage-activating protein)/SREBP-1 pathway glioblastoma (GBM) growth. Epidermal growth receptor (EGFR) signaling enhances expression GBM cells via upregulation SCAP/SREBP-1, SREBP-1 activates to specific sites its promoter. In turn,...
Immune checkpoint inhibitors can improve the prognosis of patients with advanced malignancy; however, only a small subset colorectal cancer in microsatellite-instability-high or mismatch-repair-deficient benefit from immunotherapy. Unfortunately, mechanism behind this ineffectiveness is unclear. The tumor microenvironment plays critical role immunity, and may contribute to inhibition immune other novel immunotherapies cancer. Herein, we demonstrate that DNase I enzyme pivotal degradation...
Neuroinflammation caused by peripheral lipopolysaccharides (LPS) under hypoxia is a key contributor to the development of high altitude cerebral edema (HACE). Our previous studies have shown that gypenosides and their bioactive compounds prevent hypoxia-induced neural injuries in vitro vivo. However, effect on neuroinflammation-related HACE remains be illustrated. The present study aimed investigate effects GP-14 mouse model.HACE mice were treated with (100 200 mg/kg) for 7 days. After...
Porcine induced pluripotent stem (piPS) cell lines have been generated recently by using a cocktail of defined transcription factors, however, the features authentic piPS cells not agreed upon and most published iPS clones did meet stringent requirements pluripotency. Here, we report generation from fibroblasts retrovirus carrying four mouse factors (mOct4, mSox2, mKlf4 mc-Myc, 4F). Multiple LIF-dependent were these showed morphology similar to embryonic other cells. In addition routine...