A5101743417- Platelet Disorders and Treatments
- Lung Cancer Research Studies
- MicroRNA in disease regulation
- Drug Transport and Resistance Mechanisms
- Advanced Glycation End Products research
- Renal Diseases and Glomerulopathies
- Transplantation: Methods and Outcomes
- Peroxisome Proliferator-Activated Receptors
- Dental Implant Techniques and Outcomes
- Lung Cancer Treatments and Mutations
- Cholesterol and Lipid Metabolism
- Inflammation biomarkers and pathways
- RNA modifications and cancer
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune cells in cancer
- Mesenchymal stem cell research
- Cardiac Fibrosis and Remodeling
- Sirtuins and Resveratrol in Medicine
- Cancer-related molecular mechanisms research
- Lung Cancer Diagnosis and Treatment
- Inflammasome and immune disorders
- Peptidase Inhibition and Analysis
- Mechanical Circulatory Support Devices
- Autophagy in Disease and Therapy
- Immune Cell Function and Interaction
Haier Group (China)
2023
Tongji University
2015-2022
Shanghai Pulmonary Hospital
2015-2022
Peking University
2013-2020
National Health and Family Planning Commission
2020
Ministry of Education of the People's Republic of China
2020
Chinese Academy of Medical Sciences & Peking Union Medical College
2020
Peking University First Hospital
2013-2020
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2016
Meharry Medical College
2009-2012
Abstract In response to infection, polymorphonuclear neutrophils (PMN) are recruited in the infectious sites, and employ three major strategies fight against microbes including phagocytosis, degranulation, neutrophil extracellular traps (NETs). NETs a meshwork of chromatin fibers mixed with granule-derived antimicrobial peptides enzymes, which trap kill bacteria extracellularly. this study, by using mouse sepsis model, we identified novel mechanism induce macrophage (Mϕ) pyroptosis,...
Hemorrhagic shock (HS) often renders patients more susceptible to lung injury by priming for an exaggerated response a second infectious stimulus. Acute (ALI) is major component of multiple organ dysfunction syndrome following HS and regularly serves as cause patient mortality. The vascular endothelium active that has central role in the development ALI through synthesizing releasing number inflammatory mediators. Cell pyroptosis caspase-1-dependent regulated cell death, which features rapid...
Background: Lung cancer is the most common that caused by perturbation of regulatory pathways rather than dysfunction a single gene. Cisplatin (CDDP; cis-diamminedichloroplatinum II) first member class platinum-containing anti-cancer medication, which binds to DNA and triggers apoptosis. CDDP-based chemotherapy used treat various types cancers. However, efficacy CDDP in treatment non-small-cell lung (NSCLC) limited acquired drug resistance. MicroRNAs have recently emerged as key regulators...
Both endoplasmic reticulum (ER) stress and macrophage diversity contribute to inflammatory processes in lung injury. However, the interaction between ER M1/M2 imbalance inflammation remains unclear. The present study, thus, aimed evaluate role of stress-mediated phenotype changes lipopolysaccharide (LPS)-induced acute injury (ALI).Lung were examined a murine model LPS-induced ALI with or without inhibitors. Alveolar (AM) polarization was determined by flow cytometry. Bone marrow-derived...
Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality globally. Fine particulate matter (PM2.5) has been indicated to be detrimental risk factor for COPD by numerous epidemiological studies. Histone deacetylase 2 (HDAC2), critical regulator chromatin remodeling, plays pivotal role in the development COPD. However, underlying mechanisms regarding relationship between PM2.5 HDAC2 pathogenesis have yet elucidated. In present study, we aim investigate mechanism...
Background IgA nephropathy (IgAN) is a complex syndrome characterized by deposition of and containing immune complexes (ICs) composed IgG complement C3 proteins in the mesangial area glomeruli. The low-affinity receptors for Fc region (FcγRs) are involved autoantibody/immune complex-induced organ injury as well ICs clearance. aim study was to associate multiple polymorphisms within FCGR gene locus with IgAN large Chinese cohort. Patients Methods 60 single nucleotide (SNPs) spanning 400 kb...
ATP binding cassette A1 (ABCA1) is a membrane protein that promotes cellular cholesterol efflux. Using RAW 264.7 macrophages, we studied the relative effects of apolipoprotein (apo) E3 and apoE4 on ABCA1 signaling pathway regulates its expression. Both lipid-associated lipid-free forms induced ∼30% lower levels mRNA than apoE3 forms. Phosphorylated phosphoinositol 3-kinase (PI3K), kinase Cζ (PKCζ) specificity 1 (Sp1) were also when treated with compared to apoE3. The reduced ability induce...
Abstract Bone marrow-derived mesenchymal stem cells (MSCs) are pluripotent that show a vital potential in the clinical application for cell transplantation. In present paper, proteomic techniques were used to approach protein profiles associated with porcine bone marrow MSCs and investigate regulation of MSC proteins on effect 5-azacytidine (5-aza). Over 1,700 species separated from according gel analysis. Compared expression profiling control MSCs, there 11 spots up-regulated 26...
Despite the well known importance of apolipoprotein (Apo) E in cholesterol efflux, effect ApoE on expression ATP-binding cassette transporter A1 (ABCA1) has never been investigated. The objective this study was to determine ApoB-carrying lipoprotein-induced ABCA1, a protein that mediates efflux. Our data demonstrate lipoproteins obtained from both wild-type and knockout mice induced ApoAI-mediated efflux mouse macrophages, which associated with an enhanced ABCA1 promoter activity, increased...
Accumulating evidences proved the important roles of circulating IgA1-containing immune complexes (cIgA1) in IgA nephropathy (IgAN). Galactose-deficient IgA1 (Gd-IgA1) and glycan-specific IgG antibody have been identified as major components cIgA1. Before, Gd-IgA1 was reported a vital factor IgAN, partly via its pathogenic role to induce mesangial cells activation. However, we still lack direct clarify biological effect IgAN.In present study, enrolled 35 IgAN patients 17 age- sex-matched...
Hepatitis B virus (HBV) is a major cause of liver infection in human. Because the lack an appropriate cell culture system for supporting HBV efficiently, cellular and molecular mechanisms hepadnavirus remain incompletely understood. Duck heptatitis (DHBV) can naturally infect primary duck hepatocytes (PDHs) that provide valuable model systems studying vitro. In this report, we explored global changes protein expression DHBV infected PDHs by two-dimension gel electrophoresis (2-DE) combined...
Circulating IgA1-containing immune complexes (cIgA1) were shown to play important roles in IgA nephropathy (IgAN). They could induce the release of multiple inflammatory factors, including MCP-1 and IL-6, elevated urinary factors also reported patients with IgAN, which suggested that inflammation is a major contributor kidney injury IgAN. After previous identification upregulated soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) by mesangial cells under cIgA1 challenge using...
Previous studies have shown that the presence of EGFR T790M mutation may reduce treatment efficacy tyrosine kinase inhibitors (TKIs) in EGFR-mutant lung cancer. However, little is known about clinical features and outcomes pretreated patients with NSCLC.The EGFR-activating mutations were assessed a large cohort EGFR-TKI-naïve NSCLC (all/EGFR mutations, n=16,347/7,687). The correlation between pretreatment status was evaluated using univariate multivariate analyses.Pretreatment reported 1.39%...
The echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK) fusion gene is a key oncogenic driver in non-small cell lung cancer (NSCLC). This study analyzed the clinicopathological characteristics and prognostic significance of EML4-ALK patients with surgically resected adenocarcinoma.The 1056 consecutive stage I-IIIA adenocarcinoma were collected from February 2014 to October 2014, rearrangement was detected using real-time polymerase chain reaction (RT-PCR)...
An accurate genotyping analysis is one of the critical prerequisites for lung cancer targeted therapy. Here, a quantitative polymerase chain reaction (qPCR)-based mutation detection system, mutation-selected amplification-specific system PCR (MASS-PCR), developed. The specific primers and probes used in MASS-PCR exactly match with mutant sequence that only allows gene to emit fluorescence peak. To determine sensitivity MASS-PCR, 717 specimens, 61 formalin-fixed paraffin-embedded (FFPE)...
Objectives: A retrospective study was performed to investigate the association between EGFR mutations and visceral pleural invasion (VPI), evaluate prognostic value of in resected non-small-cell lung cancer (NSCLC) patients with VPI. Materials methods: Clinicopathological characteristics follow-up information were collected from 508 consecutive surgically stage I–III NSCLC, detected based on real-time PCR technology. Significant results ( P <0.05) univariate logistic regression analysis...