A5016759739- Renal Diseases and Glomerulopathies
- Systemic Lupus Erythematosus Research
- Celiac Disease Research and Management
- Monoclonal and Polyclonal Antibodies Research
- Platelet Disorders and Treatments
- Traditional Chinese Medicine Analysis
- Acute Myocardial Infarction Research
- T-cell and B-cell Immunology
- Immunodeficiency and Autoimmune Disorders
- Cancer-related molecular mechanisms research
- Eosinophilic Esophagitis
- Atrial Fibrillation Management and Outcomes
- Radiomics and Machine Learning in Medical Imaging
- Antiplatelet Therapy and Cardiovascular Diseases
- Pediatric health and respiratory diseases
- Autophagy in Disease and Therapy
- Asthma and respiratory diseases
- Amino Acid Enzymes and Metabolism
- Fibroblast Growth Factor Research
- Proteoglycans and glycosaminoglycans research
- Glycosylation and Glycoproteins Research
- Chronic Lymphocytic Leukemia Research
- Neuroendocrine Tumor Research Advances
- Diabetes Treatment and Management
- Pancreatic and Hepatic Oncology Research
Northwest A&F University
2025
China Medical University
2004-2025
Liaoning University of Traditional Chinese Medicine
2012-2025
Affiliated Hospital of Liaoning University of Traditional Chinese Medicine
2012-2025
Zigong First People's Hospital
2025
Fujian Medical University
2025
First Affiliated Hospital of Zhengzhou University
2019-2024
Nagano College of Nursing
2022-2024
Yangzhou University
2022-2024
Peking University
2013-2023
Although high serum levels of galactose-deficient IgA1 (an important biomarker IgA nephropathy (IgAN)) are found in most patients with IgAN, their relationship to disease severity and progression remains unclear. To help clarify this we prospectively enrolled 275 IgAN followed them for a median 47 months (range 12–96 months). Serum galactose–deficient was measured at the time diagnosis using lectin-based ELISA, renal survival modeled Cox proportional hazards method. The were higher compared...
With the development of biotechnologies and computational prediction algorithms, number experimental RNA-associated interactions has grown rapidly in recent years. However, diverse are scattered over a wide variety resources organisms, whereas fully comprehensive view is still not available for any species. Hence, we have updated RAID database to version 2.0 (RAID v2.0, www.rna-society.org/raid/) by integrating from manually reading literature other under one common framework. The new...
Risk alleles at genome loci containing phospholipase A2 receptor 1 (PLA2R1) and HLA-DQA1 closely associate with idiopathic membranous nephropathy (IMN) in the European population, but it is unknown whether a similar association exists Chinese population high-risk promote development of anti-PLA2R antibodies. Here, we genotyped 2132 individuals, including 1112 patients IMN 1020 healthy controls, for three single nucleotide polymorphisms (SNPs) within PLA2R1 SNPs HLA genes. We also selected 71...
Complement activation is common in patients with IgA nephropathy (IgAN) and associated disease severity. Our recent genome-wide association study of IgAN identified susceptibility loci on 1q32 containing the complement regulatory protein-encoding genes CFH CFHR1-5, rs6677604 as top single-nucleotide polymorphism CFHR3-1 deletion (CFHR3-1∆) signal for copy number variation. In this study, to explore clinical effects variation CFH, CFHR3, CFHR1 progression, we enrolled two populations. Group 1...
Aberrant O-glycosylation of serum immunoglobulin A1 (IgA1) represents a heritable pathogenic defect in IgA nephropathy, the most common form glomerulonephritis worldwide, but specific genetic factors involved its determination are not known. We performed quantitative GWAS for levels galactose-deficient IgA1 (Gd-IgA1) 2,633 subjects European and East Asian ancestry discovered two genome-wide significant loci, C1GALT1 (rs13226913, P = 3.2 x 10-11) C1GALT1C1 (rs5910940, 2.7 10-8). These genes...
Objective More recent studies suggested that defects in autophagy contribute to the pathogenesis of SLE, especially adaptive immunity. Occurrence and progression lupus nephritis (LN) is end result complex interactions between regulation immune responses pathological process by renal resident cells, but there still a lot missing information for an establishment on role LN as therapy target. Methods Systemic organ-specific aetiologies were first evaluated protein quantification tissue...
An intronic variant at the complement factor H ( CFH ) gene on chromosome 1q32 (rs6677604) associates with risk of IgA nephropathy (IgAN), but association signal has not been uniformly replicated in Han Chinese populations. We investigated whether causal sequence resides or neighboring H–related 1 CFHR1 and CFHR3 , which harbor an 84-kb combined deletion CFHR3,1Δ linkage disequilibrium rs6677604. Imputation 1000 Genomes Project data did suggest new single–nucleotide variants within cluster....
The aim of this study was to determine whether Saccharomyces boulardii prevents and treats diarrhoea antibiotic-associated (AAD) in children. A total 333 hospitalised children with acute lower respiratory tract infection were enrolled a 2-phase open randomised controlled trial. During the 1 st phase, all received intravenous antibiotics (AB). They randomly allocated group ( S. 500 mg/day + AB, n=167) or B (AB alone, n=166) followed for 2 weeks. Diarrhoea defined as ≽3 loose/watery stools/day...
Significance Statement Galactose-deficient IgA1 plays a key role in the pathogenesis of IgA nephropathy. Although variability serum levels galactose-deficient has strong genetic component, link between this molecule and nephropathy not yet been clearly determined. The authors performed genome-wide association study among 1127 patients with Chinese population, identifying two significant loci, which one is novel. They also observed potential associations loci susceptibility to In addition,...
Sitophilus zeamais is a highly destructive pest of stored grains worldwide. To develop novel RNA insecticides, the double-stranded S. cytochrome c oxidase (dsSzCOXs: dsSzCOXI, dsSzCOXII, and dsSzCOXIII) was successfully expressed in pET28a-BL21(DE3)-RNaseIII- system remarkably downregulated expression level SzCOXs through injection or feeding methods, leading to high mortalities both larvae adults. Under their optimal conditions (isopropyl β-d-thiogalactoside, 0.6 mM), yields dsSzCOXI (at 28...
Background The relationship between body mass index (BMI) and the risk of sick sinus syndrome (SSS) remains unclear. Clarifying impact BMI on SSS at different life stages is essential for advancing precision medicine implementing effective prevention strategies to reduce burden SSS. Methods causalities childhood adult with were investigated by univariate multivariate Mendelian randomization. Reverse also explored improve accuracy causality findings. Different sources exposure data used...
The rise in incidence and mortality of gastrointestinal mixed adenoneuroendocrine carcinoma (MANEC) has not been well focused. aim our study was to examine epidemiological trends incidence-based (IB) MANEC at a population level.The IB as data on affected patients from 2000 2016 were obtained the Surveillance, Epidemiology, End Results database. Trends assessed using Joinpoint regression. Kaplan-Meier method log-rank test used for survival analysis. Cox proportional hazards regression...
Recently, several studies have provided convincing evidence that polymorphisms in the interferon regulatory factor 5 (IRF5) gene were significantly associated with systemic lupus erythematosus (SLE) populations. The aim of this study was to investigate association between IRF5 and nephritis a Chinese cohort analyze relationship rs2004640 genotype clinical pathological phenotypes nephritis.The polymorphism 190 patients 182 healthy blood donors analyzed. examined genotyped using TaqMan assay....
Background IgA nephropathy (IgAN) is a complex syndrome characterized by deposition of and containing immune complexes (ICs) composed IgG complement C3 proteins in the mesangial area glomeruli. The low-affinity receptors for Fc region (FcγRs) are involved autoantibody/immune complex-induced organ injury as well ICs clearance. aim study was to associate multiple polymorphisms within FCGR gene locus with IgAN large Chinese cohort. Patients Methods 60 single nucleotide (SNPs) spanning 400 kb...