A5100376798- Enzyme Production and Characterization
- Phytochemical compounds biological activities
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Tea Polyphenols and Effects
- Epigenetics and DNA Methylation
- Phytochemicals and Antioxidant Activities
- MicroRNA in disease regulation
- Algal biology and biofuel production
- Catalytic C–H Functionalization Methods
- Ion Transport and Channel Regulation
- Cancer-related molecular mechanisms research
- Radical Photochemical Reactions
- Antioxidant Activity and Oxidative Stress
- Asymmetric Synthesis and Catalysis
- Birth, Development, and Health
- Seaweed-derived Bioactive Compounds
- Circular RNAs in diseases
- Bone Metabolism and Diseases
- Food Quality and Safety Studies
- Synthesis and Catalytic Reactions
- Electrolyte and hormonal disorders
- Photosynthetic Processes and Mechanisms
- Sulfur-Based Synthesis Techniques
- Ion channel regulation and function
Qingdao Agricultural University
2022-2025
Jimei University
2016-2025
Zhejiang University
2022-2025
Inner Mongolia Agricultural University
2020-2025
Hebei University
1996-2025
Xiamen University
2014-2025
Sir Run Run Shaw Hospital
2025
Fujian Medical University
2025
Harbin Medical University
2025
Third Affiliated Hospital of Harbin Medical University
2025
Pyroptosis has been reported to improve the immunosuppressive tumor microenvironment and may be a strategy enhance osteosarcoma treatment. The extent which modulation of mitochondria could induce pyroptosis immunotherapy not characterized. We synthesized mitochondria-targeting polymer micelle (OPDEA-PDCA), in poly[2-(N-oxide-N,N-diethylamino)ethyl methacrylate] (OPDEA) was used target conjugated dichloroacetate (DCA) inhibit pyruvate dehydrogenase kinase 1 (PDHK1). This conjugate induced...
Electrochemical generation of N-acyloxy amidyl radicals via an inner-sphere electron-transfer process is described for the first time. With NaBr as catalyst and electrolyte, in situ generated undergo intramolecular C(sp2/sp3)-H aminations to give lactams with unprecedented regio- chemoselectivities. Moreover, synthetic utility current method demonstrated by synthesis PJ34 Phenaglaydon.
A practical, electrochemical method is developed for the direct dehydrogenative lactonization of C(sp2/sp3)–H bonds under external oxidant- and metal-free conditions, delivering diverse lactones, including coumarin derivatives with excellent regioselectivity. The scalable nature this newly process was demonstrated on a 40 g scale following an operationally simple protocol. remote C(sp3)–H would constitute important synthetic advance toward C–O bond formation.
Abstract Arylation of carbonyls, one the most common approaches toward alcohols, has received tremendous attention, as alcohols are important feedstocks and building blocks in organic synthesis. Despite great progress, there is still a gap to develop an ideal arylation method featuring mild conditions, good functional group tolerance, readily available starting materials. We now show that electrochemical can fill gap. By taking advantage synthetic electrochemistry, commercially aldehydes...
An effective enantioselective bromoaminocyclization of allyl N-tosylcarbamates catalyzed by a chiral phosphine–Sc(OTf)3 complex is described. A wide variety optically active oxazolidinone derivatives containing various functional groups can be obtained with high enantioselectivities.
The rational development and utilization of saline soils brackish water resources has aroused great concern in the world. In present study, soil column leaching indoor simulation method was conducted to explore salt migration characteristics highly soil. Both (2.84 g/L) Yellow River Water (0.51 were used for analyze compare their corresponding required volume, desalination rate, chemical ion composition. results showed that (1) volume 535–875 mm 455–1125 (depth is 100 cm), respectively. time...
Previously we showed that neuropeptide Y (NPY), a sympathetic vasoconstrictor neurotransmitter, stimulates endothelial cell migration, proliferation, and differentiation in vitro. Here, report on NPY's actions, receptors, mediators ischemic angiogenesis. In rats, hindlimb ischemia NPY release (attenuated by lumbar sympathectomy) upregulates NPY-Y2 (Y2) receptor peptidase forming Y2/Y5-selective agonist. Exogenous at physiological concentrations also induces Y5 receptor, neovascularization,...
A bifunctional amino sulfonohydrazide which contains multiple sites for hydrogen bonding with substrates was found to enhance reactivity and enantioselectivity in the direct asymmetric Mannich reaction of N-sulfonyl cyclic ketimines ketones. In this efficient transformation, not only methyl ketones but also can be employed provide a general methodology construct tetrasubstituted α-amino ester stereoselective manner. The synthetic utility substituted product is demonstrated by synthesis...
Dingxin Recipe (DXR) is a traditional Chinese medicine formula that has been reported to be effective and safe treatment for cardiovascular diseases, such as arrhythmias, coronary heart disease. IV (DXR IV) was further improved from the DXR according use. However, mechanism of in atherosclerosis unclear. This study aimed illustrate whether improve through modulating lipid metabolism gut microbiota mice. 40 male ApoE-/- mice were fed on HFD 12 weeks then treated with (1.8, 0.9, or 0.45...
Gram-negative bacteria of the genus Serratia are potential producers many useful secondary metabolites, such as prodigiosin and serrawettins, which have applications in environmental bioremediation or pharmaceutical industry. Several strains produce serrawettin W1 main bioactive compounds, biosynthetic pathways co-regulated by quorum sensing (QS). In contrast, strain, can simultaneously W2, has not been reported. This study focused on analyzing genomic sequence sp. strain YD25T isolated from...
A combination of polysaccharides and tea polyphenols can enhance immune activity synergistically, depending on the type structure polysaccharides, but mechanism remains unknown. This study is aimed to investigate regulating effects different seaweed polysaccharide (ι-carrageenan, agarose) polyphenol blends intestinal flora inflammation using an in vitro ascending-transverse-descending colon fermentation system RAW264.7 cell model. The results showed that presence were almost completely...