A5100331932- T-cell and Retrovirus Studies
- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Ophthalmology and Eye Disorders
- Corneal surgery and disorders
- Retinal and Macular Surgery
- Retinal and Optic Conditions
- Inflammasome and immune disorders
- Ocular Surface and Contact Lens
- Virology and Viral Diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- MicroRNA in disease regulation
- HIV/AIDS Research and Interventions
- interferon and immune responses
- Neuroinflammation and Neurodegeneration Mechanisms
- Respiratory viral infections research
- Liver Disease Diagnosis and Treatment
- Advanced biosensing and bioanalysis techniques
- Angiogenesis and VEGF in Cancer
- Intergenerational Family Dynamics and Caregiving
- Immune Response and Inflammation
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Circular RNAs in diseases
First People's Hospital of Foshan
2025
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2022-2025
University of Electronic Science and Technology of China
2024-2025
The First People's Hospital of Xiaoshan District, Hangzhou
2025
Wenzhou Medical University
2025
Third Affiliated Hospital of Sun Yat-sen University
2015-2024
Sun Yat-sen University
2012-2024
Jinan University
2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2023-2024
Chongqing Medical University
2023-2024
Background Substantial evidence suggests that the presence of inflammatory cells plays a critical role in development and/or progression human tumors. Neutrophils are common tumors; however, infiltration intratumoral neutrophils colorectal carcinoma (CRC) and its effect on CRC patients' prognosis poorly understood. Methodology/Principal Findings In this study, methods tissue microarray immunohistochemistry (IHC) were used to investigate prognostic significance CD66b+ neutrophil CRC....
Nod-like receptor protein 3 (NLRP3) inflammasome is a crucial factor in mediating inflammatory responses after cerebral ischemia/reperfusion (I/R), but the cellular location of NLRP3 I/R has yet come to conclusion, and there still no specific evidence state relationship between mitochondria I/R.In present study, we detected localization inflammasomes transient middle artery occlusion (tMCAO) rat model transwell co-culture cell system under oxygen-glucose deprivation/reoxygenation (OGD/R)...
Atherosclerosis is a leading cause of death worldwide. Recent studies have emphasized the significance gut microbiota and lipid metabolism in development atherosclerosis. Herein, effects molecular mechanisms involving ferulic acid (FA) was examined atherosclerosis using ApoE-knockout (ApoE -∕- , c57BL/6 background) mouse model. Eighteen male ApoE −/− mice were fed high-fat diet (HFD) for 12 weeks then randomly divided into three groups: model group, FA (40 mg/kg/day) group simvastatin (5...
Abstract Background Circular RNAs (CircRNAs) have been associated with acute lung injury (ALI), but their molecular mechanisms remain unclear. Methods This study developed a rat model of lipopolysaccharide (LPS)-induced ALI and evaluated the modeling effect by hematoxylin eosin staining, Masson’s trichrome wet-to-dry weight ratio, terminal deoxynucleotidyl transferase UTP nick end labeling (TUNEL), enzyme-linked immunosorbent assay (ELISA) detection inflammatory factors (interleukin-1β,...
In China, the rapid rate of population aging and changes in prevalence disability among elderly people could have significant effects on demand for long-term care. This study aims to describe urban-rural differences use cost care disabled explore potential influencing factors.This uses data from a cross-sectional survey qualitative investigation conducted Zhejiang province 2012. The participants were 826 individuals over 60 years age, who had been bedridden or suffered dementia more than 6...
Dingxin Recipe (DXR) is a traditional Chinese medicine formula that has been reported to be effective and safe treatment for cardiovascular diseases, such as arrhythmias, coronary heart disease. IV (DXR IV) was further improved from the DXR according use. However, mechanism of in atherosclerosis unclear. This study aimed illustrate whether improve through modulating lipid metabolism gut microbiota mice. 40 male ApoE-/- mice were fed on HFD 12 weeks then treated with (1.8, 0.9, or 0.45...
Biodegradable BSA@ZIF-8 can treat cancer by tumor microwave ablation, while simultaneously inhibiting bacteria and resisting infection.
Abstract Imaging of muscular structure with cellular or subcellular detail in whole-body animal models is key importance for understanding disease and assessing interventions. Classical histological methods high-resolution imaging require excision, fixation staining. Here we show that the three-dimensional unstained whole zebrafish can be imaged sub-5 μm X-ray phase-contrast tomography. Our method relies on a laboratory propagation-based system tailored detection low-contrast 4–6 myofibrils....
To investigate the distribution of diabetic retinopathy (DR) by sex in patients with type 2 diabetes mellitus (T2DM) a twelve-province cross-sectional study China. Patients T2DM, whose ages were ≥18 years, recruited from 76 cities/counties 12 provinces mainland China between January 2015 and December 2018. All participants received standardized interview, eye examinations, digital fundus photography. The presence severity DR diagnosed classified retina specialists according to domestic...
Triple-negative breast cancer (TNBC) is a highly lethal malignancy with limited therapy options. Aberrant metabolism, key hallmark of human cancers, plays crucial role in tumor progression, therapeutic responses and TNBC-related death. However, the underlying mechanisms are not fully understood. In this study, we delineate previously unrecognized aberrant glucose metabolism regulating turnover Snail1, which transcriptional factor epithelial-mesenchymal transition (EMT) critically contributes...
Background: Essential hypertension (EH) is a chronic disease of universal high prevalence and well-established independent risk factor for cardiovascular cerebrovascular events.The regulation blood pressure crucial improving life quality prognoses in patients with EH.Therefore, it important clinical significance to develop prediction models recognize individuals EH.Methods: In total, 965 subjects were recruited.Clinical parameters genetic information, namely EH related SNPs collected each...
Abstract Background: Normal tension glaucoma (NTG) is a less pressure-dependent type of with characteristic optic neuropathy. Recently, the biomechanical mechanism has been thought to account for glaucomatous neuropathy some degree. We intended compare dynamic corneal response parameters (DCRs) among patients primary open-angle normal or hypertension and controls. The correlations between DCRs known risk factors were also analyzed. Methods: In this cross-sectional study, 49 NTG subjects, 45...
Neointimal hyperplasia (NIH) is the fundamental cause for vascular diseases and smooth muscle cell (VSMC) dysregulation has been widely implicated in NIH. Neutrophil elastase a potential therapeutic target multiple diseases. We investigated role of neutrophil VSMC functions injury-induced NIH explored targeting NIH.VSMCs were used to analyse effects elastase. Proteomic analysis was identify targets. Artery injury model inhibitor GW311616A investigate NIH.TNF-α up-regulated VSMCs through...
Digoxin is a cardiac glycosylated steroid-like drug with positive inotropic effect and has been widely used in treating congestive heart failure, atrial fibrillation, flutter, other diseases. also dangerous drug, which can cause poisoning at low blood concentration (2.73-3.9 nmol/L, i.e., 2.14-3.05 ng/mL). Therefore, the timely detection of patient's plays significant role controlling concentration, reducing occurrence events, maximizing therapy. In this study, DNA vector for expression...
This study aimed to examine menopausal symptoms and their associated factors among premenopausal, perimenopausal postmenopausal groups of middle-aged Chinese women. The nationwide cross-sectional involved 9740 women from 115 medical centers across 27 provinces in China. Logistic regression analyses were performed explore the associations between symptom severity age, status, body mass index (BMI), smoking, employment income, education level, exercise alcohol use. Among participants, 17.6% (n...