A5052652853- Hormonal Regulation and Hypertension
- Blood Pressure and Hypertension Studies
- Mitochondrial Function and Pathology
- Adipose Tissue and Metabolism
- Renin-Angiotensin System Studies
- Stress Responses and Cortisol
- ATP Synthase and ATPases Research
- Cardiovascular Disease and Adiposity
- Apelin-related biomedical research
- Genetic Associations and Epidemiology
- Metabolomics and Mass Spectrometry Studies
- Cardiovascular Function and Risk Factors
- Sodium Intake and Health
- Receptor Mechanisms and Signaling
- Nutritional Studies and Diet
- RNA modifications and cancer
- Hormonal and reproductive studies
- Nutrition, Genetics, and Disease
- Coronary Interventions and Diagnostics
- Nitric Oxide and Endothelin Effects
- Cardiovascular Health and Risk Factors
- Heart Rate Variability and Autonomic Control
- Antiplatelet Therapy and Cardiovascular Diseases
- RNA Research and Splicing
- Diet and metabolism studies
Capital Medical University
2015-2025
Beijing Anzhen Hospital
2015-2025
Beijing Institute of Water
2019-2022
Capital University
2011
Myocardial hypertrophy is an important cause of heart failure and sudden death. Studies have shown that Mitofusin-2 (MFN2) downregulated in myocardial hypertrophy, but the upstream regulation mechanism underlying its downexpression cardiomyocytes still unclear. This study aims to identify expression profile microRNAs (miRNAs) hypertrophic cardiomyopathy (HCM) explore function miRNA-20 inducing cardiomyocyte through regulating MFN2. Through miRNA + mRNA microarray analysis, 1451 miRNAs were...
Background: Essential hypertension (EH) is a chronic disease of universal high prevalence and well-established independent risk factor for cardiovascular cerebrovascular events.The regulation blood pressure crucial improving life quality prognoses in patients with EH.Therefore, it important clinical significance to develop prediction models recognize individuals EH.Methods: In total, 965 subjects were recruited.Clinical parameters genetic information, namely EH related SNPs collected each...
Hyperplasia suppressor gene/mitofusion-2 (HSG/Mfn2) is a hyperplasia gene and an essential component of mitochondrial fusion machinery; however, the association between single nucleotide polymorphism (SNP) HSG/Mfn2 hypertension unclear.In this study, 542 normotensive subjects (NT group) 539 hypertensive patients (EH were screened for study hypertension.The results showed that genotype distribution allelic frequency rs873457, rs2336384, rs1474868, rs4846085 rs2236055 significantly different...
Genetic variation is thought to contribute the etiology of hypertension, and E-selectin a candidate essential hypertension-associated gene. This study thus sought investigate possible genetic associations between T1880C, C602A T1559C polymorphisms hypertension.Hypertensive patients (n = 490) healthy normotensive subjects 495) were screened for genotypes using real-time quantitative polymerase chain reaction after DNA extraction identify representative variations in The alleles three...
Background The β2-adrenergic receptor (ADRB2) gene has been widely researched as a candidate for essential hypertension (EH), but no consensus reached in different ethnicities. aim of the present study was to evaluate possible association between ADRB2 polymorphisms and EH risk Northern Han Chinese population. Methodology/Principal Findings This included 747 hypertensive subjects 390 healthy volunteers control Chinese. Genotyping performed identify C-47T, A46G C79G gene. G allelic frequency...
Nax, an α-subunit of the sodium channel encoded by SCN7A gene, has been deemed to be a sensor concentration in brain and may involved salt intake behavior. We inferred that Nax/SCN7A participate regulation blood pressure pathogenesis essential hypertension (EH). The present case-control study involving 615 hypertensives 617 normotensives was performed investigate association between polymorphisms EH Northern Han Chinese population. three common single nucleotide (SNPs) (rs3791251, rs6738031,...
Previous studies found visit-to-visit heart rate variability (VVHRV) may be positively associated with risks of several cardiovascular events, but whether VVHRV affected the benefit intensive blood pressure control remained unknown. In this study, we assessed risk composite outcomes among older patients hypertension and evaluated in prevention was consistent context elevated VVHRV.This a post-hoc analysis Systolic Blood Pressure Intervention Trial (SPRINT). We explored relationship between...
To explore the association between three polymorphisms [ C825T, C1429T and G(-350)A] of gene encoding G protein beta 3 subunit (GNB3) hypertension by performing a case-control study in northern Han Chinese population.We recruited 731 hypertensive patients 673 control subjects (the calculated power value was > 0.8). Genotyping performed to identify G(-350)A using TaqMan assay. Comparisons allelic genotypic frequencies cases controls were made chi-square test. Logistic regression analyses...