A5007149366- Seaweed-derived Bioactive Compounds
- Catalytic Processes in Materials Science
- Cytokine Signaling Pathways and Interactions
- Advanced biosensing and bioanalysis techniques
- Immune Response and Inflammation
- Inflammatory mediators and NSAID effects
- Alzheimer's disease research and treatments
- Nanomaterials for catalytic reactions
- Carbon and Quantum Dots Applications
- Electrocatalysts for Energy Conversion
- Liver Disease Diagnosis and Treatment
- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
- Endoplasmic Reticulum Stress and Disease
- Functional Brain Connectivity Studies
- Advanced Photocatalysis Techniques
- Eicosanoids and Hypertension Pharmacology
- Anomaly Detection Techniques and Applications
- Synthesis and biological activity
- Selenium in Biological Systems
- Advanced oxidation water treatment
- Biosensors and Analytical Detection
- Zeolite Catalysis and Synthesis
- Macrophage Migration Inhibitory Factor
- Cancer Mechanisms and Therapy
Wuhan University
2015-2025
Technische Universität Berlin
2024-2025
Renmin Hospital of Wuhan University
2015-2025
Dalian University
2024
Dalian University of Technology
2024
Sun Yat-sen University
2015-2024
Meizhou City People's Hospital
2023-2024
Xi'an International Studies University
2024
The Seventh Affiliated Hospital of Sun Yat-sen University
2020-2024
Third Affiliated Hospital of Sun Yat-sen University
2015-2023
Alginate, a natural acidic polysaccharide extracted from marine brown seaweeds, is composed of different blocks β-(1, 4)-D-mannuronate (M) and its C-5 epimer α-(1, 4)-L-guluronate (G). Alginate-derived guluronate oligosaccharide (GOS) readily activates macrophages. However, to understand role in immune responses, further studies are needed characterize GOS transport signalling. Our results show that recognized by upregulates Toll-like receptor 4 (TLR4) on RAW264.7 macrophages, followed...
Alginate has notably diverse pharmacological activities. The present study investigated the anti-inflammatory activity of guluronate oligosaccharides prepared by oxidative degradation (GOS-OD) from alginate. GOS-OD significantly attenuated production nitric oxide (NO), prostaglandin E2 (PGE2), and reactive oxygen species (ROS), expression inducible synthase (iNOS) cyclooxygenase (COX)-2, secretion pro-inflammatory cytokines in lipopolysaccharide (LPS)-activated murine macrophage RAW 264.7...
This study evaluated the immunomodulatory activities, including regulation of nitric oxide (NO), reactive oxygen species (ROS), and tumor necrosis factor (TNF)-α production in RAW264.7 murine macrophages, alginate oligosaccharides (AOS) investigated their structure-activity relationships. Our results revealed that unsaturated guluronate oligosaccharide prepared by enzymatic degradation (GOS-ED) induced NO inducible synthase (iNOS) expression, dose time dependently, stimulated ROS TNF-α...
The advent of human-induced pluripotent stem cells holds great promise for producing ample individualized hepatocytes. Although previous efforts have succeeded in generating hepatocytes from human vitro by viral-based expression transcription factors and/or addition growth during the differentiation process, safety issue viral transduction and high cost cytokines would hinder downstream applications. Recently, use small molecules has emerged as a powerful tool to induce cell fate transition...
Fucoidan, a sulfated polysaccharide extracted from brown seaweeds, has been shown to possess various bioactivities. In particular, low molecular weight fucoidan (LMWF) have better this study, LMWF (<10 kDa) was New Zealand Undaria pinnatifida and investigated for its immune modulation effects. at concentration range 1 50 μg/mL exerted an effective activation in RAW264.7 macrophages. treatment promoted significant NO release, iNOS expression, TNF-α IL-6 secretion concentration-dependent...
Alterations in P300 components occur depressed patients, but the brain regions contributing to these changes remain unclear.Thus, aim of present study was examine underlying neural activation patients with depression explore related depression.P300 were evoked by an oddball auditory paradigm and recorded from 30 current depression, as well age-, gender-, education level-matched healthy controls. The standardized Low-Resolution Brain Electromagnetic Tomography (sLORETA) method used source...
We developed a significantly improved ultra-high performance liquid chromatography-tandem mass spectrometry method for determination of 5-nitro-2-furaldehyde (NF) as surrogate using novel internal standard the detection nitrofurazone. used 2,4-dinitrophenylhydrazine derivatization and furfural standard. Derivatization was easily performed in HCl ultrasonic manipulation 5 min followed by extraction ethyl acetate. The samples were concentrated purified reverse phase alumina cartridges tandem....
Currently, drug discovery and development for clinical treatment of prostate cancer has received increased attention, specifically the STAT3 inhibitor. Our previous study reported that neuroleptic pimozide had antitumor activity against hepatocellular carcinoma cells or stem-like through suppressing activity. In present we demonstrate inhibits cell growth cellular activation in cells. results showed inhibited proliferation a dose- time-dependent manner by inducing G1 phase cycle arrest,...
Drug repurposing is currently an important approach for accelerating drug discovery and development clinical use. Hepatocellular carcinoma (HCC) presents resistance to chemotherapy, the prognosis poor due existence of liver cancer stem-like cells. In this study, we investigated effect neuroleptic agent pimozide inhibit cell maintenance tumorigenicity in HCC. Our results showed that functioned as anti-cancer HCC cells or Pimozide inhibited proliferation sphere formation capacities by inducing...
In this study, we investigated auditory-visual stimulation-induced P300 and examined whether was differentially modulated between individuals with clinical depression healthy controls. We hypothesized that the component would significantly differ Specifically, predicted induced by bimodal oddball task be different from unimodal task. Forty-five forty-five controls participated in study. All participants were instructed to complete three tasks—auditory (A), visual (V), (AV)—while their...
Abstract MALAT1-associated small cytoplasmic RNA (mascRNA) is a tRNA-like derived from nucleus-located long noncoding (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1). While MALAT1 was extensively studied and found to function in multiple cellular processes, including tumorigenesis tumor progression, the role of mascRNA largely unknown. Here we show that upregulated cancer cell lines hepatocellular carcinoma (HCC) clinical samples. Using HCC cells as model, its parent...
Alginate-derived polymannuronate (PM) is a type of polysaccharide found in edible brown seaweeds. Seleno-polymannuronate (Se-PM) was prepared from PM via synthesis using sulfation- and selenation-replacement reactions. The anti-inflammatory activity Se-PM its corresponding molecular mechanisms were investigated. In lipopolysaccharide (LPS)-activated murine macrophage RAW264.7 cells, significantly attenuated the production nitric oxide (NO), prostaglandin E2 (PGE2), reactive oxygen species...
A fluorometric assay platform based on GQDs is designed for biochemical detection of caffeic acid.
Lipid accumulation is a typical characteristic of nonalcoholic fatty liver disease (NAFLD). The inhibition lipid regarded as potential treatment for NAFLD. In this study, we investigated the effects γ-mangostin or α-mangostin on in cell model. Analysis inhibitory revealed that it downregulated NAFLD-related biochemical parameters and stimulated SIRT1/LKB1/AMPK pathway. Consequently, suppressed synthesis enhanced acid oxidation. Moreover, demonstrated blockage AMP-activated protein kinase...