A5100353136- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA Research and Splicing
- Hepatocellular Carcinoma Treatment and Prognosis
- Inflammatory Biomarkers in Disease Prognosis
- Cancer, Lipids, and Metabolism
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer, Hypoxia, and Metabolism
- Cancer Genomics and Diagnostics
- Pancreatic and Hepatic Oncology Research
- Cancer-related Molecular Pathways
- Ferroptosis and cancer prognosis
- Ovarian cancer diagnosis and treatment
- interferon and immune responses
- Mycobacterium research and diagnosis
- Cancer-related gene regulation
- Breast Cancer Treatment Studies
- Liver Disease Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Helicobacter pylori-related gastroenterology studies
- Radiomics and Machine Learning in Medical Imaging
- Epigenetics and DNA Methylation
- Lung Cancer Research Studies
Third Affiliated Hospital of Sun Yat-sen University
2020-2025
Sun Yat-sen University
2019-2025
State Grid Corporation of China (China)
2024-2025
University of Alabama at Birmingham
2024-2025
Union Hospital
2025
Jilin University
2022-2025
Shanghai Dianji University
2025
Capital Medical University
2022-2025
Southern Medical University
2014-2025
Rotterdam Eye Hospital
2024
Chemoresistance is one of the main causes poor prognosis in pancreatic cancer patients. Understanding mechanisms implicated chemoresistance critical to improving patient outcomes. Recent evidences indicate that long noncoding RNAs (lncRNAs) are involving cancer. However, lncRNAs contribute resistance and remain largely unknown. The objective this study construct a chemoresistance-related lncRNA-associated competing endogenous RNA (ceRNA) network identify key regulating network.Firstly,...
Abstract Despite recent advances in cancer immunotherapy, pancreatic ductal adenocarcinoma (PDAC) remains unresponsive due to an immunosuppressive tumor microenvironment, which is characterized by the abundance of cancer-associated fibroblasts (CAFs). Once identified, CAF-mediated immune inhibitory mechanisms could be exploited for immunotherapy. Siglec receptors are increasingly recognized as checkpoints, and their ligands, sialic acids, known overexpressed cells. Here, we unveil a...
Although serum microRNAs (miRNAs) play essential roles in the diagnosis of various diseases, little is known about circulating miRNAs aging process. Solexa sequencing technology was used for an initial miRNA screening samples pooled from 21 healthy Chinese subjects with average age 22 years, 10 40 59 and 9 70 years. Other were obtained 123 normal people approximately 31 each period. A stem-loop quantitative reverse transcription–PCR assay conducted to confirm concentrations altered...
MicroRNAs play an important role in liver cancer genesis and progression. In this study, we identified down-regulation of miR-146b-5p associated with tumor growth, metastasis poor survival hepatocellular carcinoma (HCC) patients. could suppress proliferation, migration, invasion induced apoptosis vitro vivo. Remarkably, TNF receptor factor 6 (TRAF6) was confirmed as a direct target HCC exerted the suppression roles through inhibiting phosphorylation Akt mediated by TRAF6. Furthermore, long...
Abstract Pancreatic cancer (PC) is a great health burden to patients owing its poor overall survival rate. Long noncoding RNAs (lncRNAs) interact with microRNAs (miRs) participate in tumorigenesis. Therefore, we aim uncover the role and related mechanism of LINC00473 PC through modulation miR‐195‐5p programmed death‐ligand 1 (PD‐L1). Increased PD‐L1 but declined were determined tissues cell lines, it was found that mainly situated cytoplasm. Also, verified bind both PD‐L1. Next, examine...
Although nervous and vascular systems are functionally different, they usually share similar mechanisms for function maintenance. Neurovascular dysfunction has became the pathogenesis of several disorders. Here we show that long non-coding RNA-MIAT is aberrantly expressed under neurovascular condition. MIAT shown as a regulator dysfunction, including retinal angiogenesis, corneal permeability. also neurodegeneration diabetic Mechanistically, regulates neural cell via MIAT/miR-150-5p/VEGF...
Rationale: Recently, long non-coding RNAs (lncRNAs), known to be involved in human cancer progression, have been shown encode peptides with biological functions, but the role of lncRNA-encoded cellular senescence is largely unexplored. We previously reported tumor-suppressive PINT87aa, a peptide encoded by intergenic non-protein coding RNA, p53 induced transcript (LINC-PINT). Here, we investigated PINT87aa's hepatocellular carcinoma (HCC) senescence. Methods: examined PINT87aa and truncated...
Pancreatic cancer (PC) is a highly fatal disease worldwide and often misdiagnosed in its early stages. The exploration of novel non-invasive biomarkers will definitely benefit PC patients. Recently, circulating miRNAs body fluids are emerging as for diagnosis. In this study, we first conducted comprehensive robust rank aggregation (RRA) analysis based on 21 published miRome profiling studies. We statistically identified clinically validated miRNA expression pattern These consisted four...
Abstract Background Hepatocellular carcinoma (HCC) is the world’s third leading cause of cancer-related death; due to fast growth and high prevalence tumor recurrence, prognosis HCC patients remains dismal. Long non-coding RNA CEBPA-DT, a divergent transcript CCAAT Enhancer Binding Protein Alpha (CEBPA) gene, has been shown participate in multiple progression. However, no research established its cancer-promoting mechanism yet. Methods CEBPA-DT was identified human tissues through...
Background Immune function, nutrition status, and inflammation influence tumor initiation progression. This was a retrospective multicenter cohort study that investigated the prognostic value clinical relevance of immune-, inflammatory-, nutritional-related biomarkers to develop novel immune–inflammatory–nutritional score (PIIN score) for patients with intrahepatic cholangiocarcinoma (ICC). Methods The data 571 (406 in training set 165 validation set) were collected from four large...
Facing the decarbonization trend in power systems, there appears to be a growing requirement on agile response and delicate supply from electricity suppliers. To accommodate this request, it is of key significance precisely extrapolate upcoming load, which well acknowledged as VSTLF, i.e., Very Short-Term Power Load Forecasting. As time series forecasting problem, primary challenge VSTLF how identify potential factors their very long-term affecting mechanisms load demands. With help public...
<h3>Objective</h3> The study aimed to evaluate the prognostic value of pretreatment plasma dimerized plasmin fragment D (D-dimer), fibrinogen, and platelet levels in epithelial ovarian cancer (EOC) after adjusting for venous thromboembolism (VTE) screen out patients with greatest risk poor prognosis. <h3>Methods</h3> comprised 190 EOC. D-dimer, were examined before treatment analyzed patient clinicopathological parameters, progression-free survival (PFS), overall (OS). analysis was performed...
Pretreatment nutritional and immunological statuses play an indispensable role in predicting the outcome of patients with various types malignancies. The purpose this study is to evaluate predictive value albumin/globulin ratio (AGR) overall survival (OS) recurrence hepatocellular carcinoma (HCC) following radical hepatic carcinectomy.This retrospective included a total 172 HCC complete medical follow-up information between 2002 2012. AGR was calculated according formula: = albumin/globulin....
Diabetic retinopathy (DR) is a leading cause of blindness in the working-age population, which characterized by retinal neurodegeneration and vascular dysfunction. Long non-coding RNAs (LncRNAs) have emerged as critical regulators several biological processes disease progression. Here we investigated role lncRNA AQP4-AS1 neurovascular dysfunction induced diabetes.Quantitative RT-PCR was used to detect expression pattern upon diabetes mellitus-related stresses. Visual electrophysiology...
Serum exosomal microRNAs (miRNAs) have received considerable attention as potential biomarkers for tumor diagnosis. Reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) is commonly used to detect miRNA expression levels in various types of cancer. One prerequisite valid RT‑qPCR data the correct normalization miRNAs stably expressed endogenous reference genes (RGs). The study liver carcinoma resection requires use reliable RGs order assess serum target miRNAs. However,...
Background/Aims: The development of multidrug resistance (MDR), which results in disease recurrence and metastasis, is a crucial obstacle to successful chemotherapy for patients with gastric cancer (GC). Long non-coding RNAs (lncRNAs) have been found play various roles cancer. This study aimed investigate the effect XLOC_006753 on MDR GC cells. Methods: expression levels cell lines (SGC-7901/5-FU SGC-7901/DDP line) were assessed by qRT-PCR. Statistical analyses conducted determine...
Non-small cell lung cancer (NSCLC) is the most common and cause of cancer-related mortality globally. Increasing evidence suggested that long non-coding RNAs (lncRNAs) were involved in death. To explore possible prognostic lncRNA biomarkers for NSCLC patients, present study, we conducted a comprehensive profiling analysis based on 1902 patients from Gene Expression Omnibus (GEO) The Cancer Genome Atlas (TCGA) datasets. In discovery phase, employed 682 combination four GEO datasets (GSE30219,...
Although growing evidence has demonstrated that the long noncoding RNA DLEU1 is involved in progression of various cancers, its functional role and underlying mechanisms have not been explored cervical cancer (CC). In this study, we found was up-regulated both CC tissues cell lines, overexpression significantly correlated with shorter patient survival. Knockdown suppressed proliferation invasion, whereas promoted invasion cells. Bioinformatics analysis used to elucidate potential correlation...