A5090986254- Pancreatic and Hepatic Oncology Research
- Parathyroid Disorders and Treatments
- Genetic Syndromes and Imprinting
- Pancreatitis Pathology and Treatment
- Neuroendocrine Tumor Research Advances
- Cancer-related molecular mechanisms research
- Cancer Mechanisms and Therapy
- Medical Imaging and Pathology Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Forensic and Genetic Research
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- MicroRNA in disease regulation
- Thyroid and Parathyroid Surgery
- Galectins and Cancer Biology
- Peptidase Inhibition and Analysis
- Cancer Cells and Metastasis
- Radiomics and Machine Learning in Medical Imaging
- Helicobacter pylori-related gastroenterology studies
- Pleistocene-Era Hominins and Archaeology
- Plant Virus Research Studies
- Epigenetics and DNA Methylation
- Vitamin D Research Studies
- Renal cell carcinoma treatment
- Yersinia bacterium, plague, ectoparasites research
Peking Union Medical College Hospital
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Zhongda Hospital Southeast University
2023-2025
Hunan Institute of Technology
2024
Southern University of Science and Technology
2024
Southeast University
2023
Lishui City People's Hospital
2023
Qingdao Agricultural University
2022
Qingdao University
2019-2021
Affiliated Hospital of Qingdao University
2019-2021
Chemoresistance is one of the main causes poor prognosis in pancreatic cancer patients. Understanding mechanisms implicated chemoresistance critical to improving patient outcomes. Recent evidences indicate that long noncoding RNAs (lncRNAs) are involving cancer. However, lncRNAs contribute resistance and remain largely unknown. The objective this study construct a chemoresistance-related lncRNA-associated competing endogenous RNA (ceRNA) network identify key regulating network.Firstly,...
Resident cardiac fibroblasts (CFs) play crucial roles in sensing injury signals and regulating inflammatory responses post-myocardial infarction (MI). Damaged mitochondria can be transferred extracellularly via various mechanisms, including extracellular vesicles (EVs). In this study, we aimed to investigate whether CFs could transfer damaged mitochondrial components small EVs (sEVs) elucidate their role post-MI. Left anterior descending coronary artery ligation was performed mice....
Current therapy for pancreatic cancer is multimodal, involving surgery and chemotherapy. However, development of therapies requires a thorough evaluation drug efficacy in vitro before animal testing subsequent clinical trials. Compared to two-dimensional culture cell monolayer, three-dimensional (3-D) models more closely mimic native tissues, since the tumor microenvironment established 3-D often plays significant role progression cellular responses drugs. Accumulating evidence has...
Studies of the Neanderthal and Denisovan genomes demonstrate archaic hominin introgression in Eurasians. Here, we present evidence within chromosome 3p21.31 region, occurring with a high frequency East Asians (ranging from 49.4% to 66.5%) at low Europeans. We also detected signal strong positive selection this region only Asians. Our data indicate that likely candidate targets include rs12488302-T its associated alleles—among which four are nonsynonymous, including rs35455589-G HYAL2, gene...
Abstract Background By regulating target genes, microRNAs play essential roles in carcinogenesis and drug resistance human pancreatic ductal adenocarcinoma (PDAC). Previous studies have shown that microRNA-10a-5p (miR-10a-5p) is overexpressed PDAC acts as an oncogene to promote the metastatic behavior of cells. However, role miR-10a-5p chemoresistance remains unclear. Methods The effects on biological behaviors were analyzed. MiR-10a-5p TFAP2C levels tissues detected, clinical value was...
Genetic studies of populations from the Indian subcontinent are great interest because India's large population size, complex demographic history, and unique social structure. Despite recent large-scale efforts in discovering human genetic variation, vast reservoir diversity remains largely unexplored.To analyze an unbiased sample India to investigate migration history Eurasia, we resequenced one 100-kb ENCODE region 92 samples collected three castes tribal group state Andhra Pradesh south...
The effects of PIM-1 on the progression pancreatic cancer remain unclear, and prognostic value levels in tissues is controversial. Additionally, expression clinical plasma have not been reported.The biological behaviours were analysed. detected, was evaluated.We found that knockdown cells suppressed proliferation, induced cell cycle arrest, enhanced apoptosis, resensitized to gemcitabine erlotinib treatment, inhibited ABCG2 EZH2 mRNA expression. Our results indicated EGFR pathway formed a...
The sarco/endoplasmic reticulum Ca
Abstract Purpose Parathyroid carcinoma (PC) is an endocrine malignancy with a poor prognosis. However, the diagnosis of PC still difficult problem. A model immunohistochemical (IHC) staining 5 biomarkers has been reported from limited samples for differential PC. In present study, series IHC markers was applied in relatively large to optimize diagnostic Methods this 44 patients PC, 6 atypical parathyroid tumors and 57 adenomas were included. parafibromin, Ki-67, galectin-3, protein-encoding...
Parathyroid carcinoma (PC) is a rare endocrine malignancy with poor outcomes. Although some mutations such as CDC73 have been found in patients, the molecular mechanism of PC still needs extensive data to clarify. Whole-genome sequencing (WGS) was performed frozen samples from 23 patients. Peripheral leukocytes were collected 14 patients and served controls. Somatic germline gene alterations, copy number abnormalities structural variants detected. Inactivating identified 39.1% but only one...
Abstract DNA replication follows a strict spatiotemporal program that intersects with chromatin structure but has poorly understood genetic basis. To systematically identify regulators of timing, we exploited inter-individual variation in human pluripotent stem cells from 349 individuals. We show the genome’s is broadly encoded and 1,617 cis -acting timing quantitative trait loci (rtQTLs) – sequence determinants initiation. rtQTLs function individually, or combinations proximal distal...
Skin color is one of the most visible and important phenotypes modern humans. Melanocyte-stimulating hormone its receptor played an role in regulating skin color. In this article, we present evidence Neanderthal introgression encompassing melanocyte-stimulating gene MC1R. The haplotypes from diverged with Altai 103.3 ka, which postdates anatomically human-Neanderthal divergence. We further discovered that all putative introgressive carry Val92Met variant, a loss-of-function variant MC1R...
Tumour microenvironment has been recognized as a crucial factor influencing disease progression. However, relevant features and functions are insufficiently understood in parathyroid neoplasia. Single-cell RNA sequencing was performed to profile the transcriptome of 27,251 cells from 4 adenoma (PA) tissue samples. External transcriptomic datasets immunofluorescence staining microarray were set for expression validation. Eight major cell types various subpopulations finely identified PA. We...
Plasma cell-free DNA (cfDNA) has been used to monitor gene mutations and diagnose tumors. Discriminating parathyroid carcinoma (PC) from adenoma (PA) before surgery is difficult because of the overlap in clinical features between neoplasms. We aimed detect cfDNA plasma samples PC PA patients predict CDC73 status tumor tissue help differential diagnosis Eighteen 13 were enrolled. was detected using next-generation sequencing, with matched peripheral white blood cells as a control. via...
ABSTRACT Rationale and Objectives To analyze the ultrasound features of pancreatic cystic lesions to compare contrast‐enhanced sonography (CEUS) with magnetic resonance imaging (MRI) investigate diagnostic value CEUS for lesions. Materials Methods Patients who underwent examination enhanced MRI from February 2022 January 2023 at Peking Union Medical College Hospital were prospectively included. The in diagnosis was analyzed using postoperative histopathology as gold standard compared MRI....
ABSTRACT Purpose This study aimed to construct a nomogram based on novel ultrasound vascularity features differentiate follicular thyroid carcinoma (FTC) from benign neoplasms (FBN). Methods A total of 153 patients were included. We evaluated various sonographic all nodules and analyzed the diagnostic efficiency different patterns for FTC. Furthermore, independent predictors FTC screened using multivariable logistic regression. was established predict FTC, methods used evaluate performance...
Hepatolenticular Degeneration (HLD) is a rare condition caused by genetic copper metabolism disorder and basal ganglia-dominated degenerative brain disease. Its characteristic clinical features include progressive extrapyramidal symptoms, psychiatric manifestations, cirrhosis, renal impairment, the Kayser-Fleischer ring. Furthermore, its key diagnostic bases ceruloplasmin level, oxidase activity, trace in human body, Magnetic Resonance Imaging (MRI), testing. Here, we present an HLD case...