A5100713501- Thyroid Cancer Diagnosis and Treatment
- Thyroid and Parathyroid Surgery
- Head and Neck Anomalies
- Gastric Cancer Management and Outcomes
- Radiomics and Machine Learning in Medical Imaging
- Metastasis and carcinoma case studies
- Neurological Disease Mechanisms and Treatments
- Thyroid Disorders and Treatments
- Neuroscience and Neuropharmacology Research
- S100 Proteins and Annexins
- Gastrointestinal Tumor Research and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Genetic Associations and Epidemiology
- Phytochemicals and Antioxidant Activities
- Neuroinflammation and Neurodegeneration Mechanisms
- Cerebrovascular and Carotid Artery Diseases
- Sirtuins and Resveratrol in Medicine
- Biomarkers in Disease Mechanisms
- Venomous Animal Envenomation and Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- Music Therapy and Health
- Ferroptosis and cancer prognosis
- Adipose Tissue and Metabolism
Peking Union Medical College Hospital
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Southern University of Science and Technology
2024-2025
North China University of Science and Technology
2025
Huazhong University of Science and Technology
2015-2025
Southern Medical University
2022-2024
Sichuan University
2024
Key Laboratory of Guangdong Province
2022-2024
Hebei Medical University
2010-2024
Second Hospital of Hebei Medical University
2024
Telomerase reverse transcriptase (<i>TERT</i>) promoter mutation has been reported to be associated with aggressive characteristics in differentiated thyroid cancer (DTC). This study examined the status of <i>TERT</i> distant metastatic DTC and evaluated correlation between radioiodine uptake, as well that therapy response. <b>Methods:</b><i>TERT</i> B-Raf proto-oncogene (<i>BRAF</i>) V600E were retrospectively primary tumors 66 patients DTC. Stimulated thyroglobulin (sTg) changes, uptake...
This study was sought to investigate the chemical composition and antibacterial antiulcerative colitis (UC) effects of essential oil from Pruni Semen (PSEO). A GC-MS assay showed that major compounds in PSEO were products amygdalin hydrolysis, which possessed great anti-inflammatory potential. In vitro experiments demonstrated treatment inhibited activity four kinds intestinal pathogens probably by disrupting cell wall. Further vivo studies administration significantly improved physiological...
Oxidative stress and inflammation play important roles in the development of diabetes mellitus. p-Synephrine, primary pharmacologically active protoalkaloid Citrus species, has been popularly consumed as a dietary supplement for weight loss management. However, effects p-synephrine on mellitus action mechanisms have not clearly elucidated. In this study, vitro antioxidant were evaluated. The data showed that treatment exhibited significant scavenging against DPPH, ABTS OH radicals high...
Ischaemic stroke is a serious disease with limited therapy options. Glycoprotein (GP)Ib binding to von Willebrand factor (vWF) exposed at vascular injury initiates platelet adhesion and contributes aggregation. GPIb has been suggested as an effective target for antithrombotic in stroke. Anfibatide antagonist derived from snake venom we investigated its protective effect on experimental brain ischaemia mice.Focal cerebral was induced by 90 min of transient middle artery occlusion (MCAO)....
Background The BRAF V600E and telomerase reverse transcriptase (TERT) promoter mutations have been reported in papillary thyroid carcinoma (PTC). aim of this retrospective cross-sectional study was to add further information regarding the prevalence TERT Chinese PTC their clinicopathological associations. Methods We detected mutation 455 patients analyzed association these with several features. Results 343 (75.4%) cases significantly associated older age (p<0.001) conventional subtype (p =...
Introduction: Medullary thyroid carcinoma (MTC), a rare malignancy, requires early diagnosis for optimal patient outcomes. An important aspect of MTC is the assessment serum biomarkers. This review aimed to evaluate use biomarkers in diagnosis, prognosis, and follow-up MTC. Methods: A thorough search PubMed covering 1975 2022 was conducted identify English-language articles on Results: The revealed that calcitonin (Ctn) carcinoembryonic antigen (CEA) remain most management. Despite limited...
Flexible conductive hydrogel-based electronic skin (E-skin) for simultaneous biotherapeutics and sensing applications is one of the current research directions. In this study, homogeneous silk fibroin/polyaniline/AgNP complexes (SPAg complexes) were prepared with assistance fibroin, which greatly optimized compatibility PANI hydrogel matrix. Then, SPAg was introduced into covalently crosslinked polymer network to prepare poly(acrylamide-co-sulfobetaine methacrylate) - hydrogels (labeled as...
Recent studies have shown that thyroglobulin (Tg) concentration is a useful tumor marker in follow-up of differentiated thyroid cancer (DTC) patients after thyroidectomy and subsequent radioiodine (I-131) therapy. However, its role controversial total or near-total before the first I-131 ablative treatment. So, we used thyroid-stimulating hormone (TSH) levels to normalize predictive values Tg for DTC.The study was retrospective analysis. A 244 with DTC who had undergone therapy were...
Background:The aim of this study was to investigate whether poor sleep quality third-trimester pregnancy is a risk factor for postpartum depression. Material andMethods:Third-trimester pregnant women (T0, n=293) were tested using the first socio-demographic, Pittsburgh Sleep Quality Index, and Edinburgh Postnatal Depression Scale assessments, received diagnosis Three months (T1, n=223) after delivery, scale filling finished structured interview performed again. Results:We found that 73...
Objective Primary thyroid lymphoma (PTL) is an uncommon malignancy. Despite the rarity of PTL, it important to recognize PTL promptly because its management differs from that all other neoplasms. This study was designed investigate sonographic features PTL. Methods Twenty-seven pathologically confirmed PTLs were categorized into diffuse and non-diffuse type. Sonographic including size, background echotexture, lesion echogenecity, calcification, vascularity, cervical lymphadenopathy each type...
The endocrine therapy resistance of breast cancer is the difficulty and challenge to be urgently solved in current treatment. In this study, we examined effects noncoding RNA LINC00094 miR-19a-3p on vivo vitro by RT-QPCR, Western Blot, luciferase assay, immunofluorescence drug sensitivity tests. plasma level CYP19A1 patients with was lower than that sensitive patients. Compared normal subjects, highly expressed cancer. estrogen receptor positive cells. expression promoted migration EMT cells...
Abstract Neuropathic pain causes enduring physical discomfort and emotional distress. Conventional pharmacological treatments often provide restricted relief may result in undesirable side effects, posing a substantial clinical challenge. Peripheral spinal redox homeostasis plays an important role processing perception. However, the roles of oxidative stress antioxidants analgesia on cortical region during chronic remains obscure. Here we focus ventrolateral orbital cortex (VLO), brain...
Differentiated thyroid carcinoma (DTC) is the most frequent endocrine cancer, with a high incidence in young population. Patients postoperative DTC are usually considered increased risk of bone loss, possibly due to stimulating hormone (TSH) suppression therapy. However, it remains unclear whether vitamin D and calcium supplementation beneficial on metabolism patients malnutrition after thyroidectomy DTC. In this one-year prospective study, adult men younger than 50 years or premenopausal...
Abstract Lung cancer remains the deadliest form of globally, and non-small cell lung (NSCLC) accounts for 80%-85%. Chemotherapy foundational treatment NSCLC, with platinum-based regimens serving as primary first-line therapy advanced stages disease. Cisplatin is a widely used platinum drug strong broad-spectrum anticancer activity. However, development chemotherapy resistance frequently results in failure. Consequently, further research into mechanisms underlying tumor chemoresistance...
ABSTRACT Purpose This study aimed to construct a nomogram based on novel ultrasound vascularity features differentiate follicular thyroid carcinoma (FTC) from benign neoplasms (FBN). Methods A total of 153 patients were included. We evaluated various sonographic all nodules and analyzed the diagnostic efficiency different patterns for FTC. Furthermore, independent predictors FTC screened using multivariable logistic regression. was established predict FTC, methods used evaluate performance...
Lymph node metastasis (LNM) often occurs in clinical lymph negative (cN0) papillary thyroid microcarcinoma (PTMC). The risk factors for LNM, especially high-volume were investigated this study.The medical records of 1,974 consecutive PTMC patients admitted to the Peking Union Medical College Hospital (PUMCH) from 2013 2015 reviewed. Their clinicopathological features collected. Univariate and multivariate analyses performed identify LNM/high-volume LNM.Of all patients, cervical metastases...
To investigate differences in the prevalence of left ventricular (LV) and atrial (LA) remodelling hypertensive patients using various thresholds defined by international guidelines data from Echocardiographic Measurements Normal Chinese Adults (EMINCA) study different indexation methods. LV mass (LVM), relative wall thickness, LA volume (LAV) were measured 2D echocardiography 612 healthy volunteers selected EMINCA population 306 adult with hypertension who age- gender-matched propensity...
Abstract We compared a standard antihypertensive losartan treatment with pharmacogenomics-guided rostafuroxin in never-treated Caucasian and Chinese patients primary hypertension. Rostafuroxin is digitoxigenin derivative that selectively disrupts the binding to cSrc-SH2 domain of mutant α-adducin ouabain-activated Na-K pump at 10 –11 M. Of 902 screened, 172 were enrolled Italy 107 Taiwan. After stratification for country genetic background, randomized or losartan, being difference fall...