A5005119736- Nanoplatforms for cancer theranostics
- RNA modifications and cancer
- Advanced biosensing and bioanalysis techniques
- Plant Molecular Biology Research
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- Zebrafish Biomedical Research Applications
- Pluripotent Stem Cells Research
- Cell death mechanisms and regulation
- CRISPR and Genetic Engineering
- Extracellular vesicles in disease
- Cancer, Hypoxia, and Metabolism
- Erythrocyte Function and Pathophysiology
- Ubiquitin and proteasome pathways
- Thyroid Cancer Diagnosis and Treatment
- Hemoglobinopathies and Related Disorders
- Plant biochemistry and biosynthesis
- RNA Interference and Gene Delivery
- Supramolecular Self-Assembly in Materials
- Graphene and Nanomaterials Applications
- Epigenetics and DNA Methylation
- T-cell and B-cell Immunology
- Cancer-related Molecular Pathways
- RNA Research and Splicing
- Autophagy in Disease and Therapy
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Institute of Hematology & Blood Diseases Hospital
2016-2025
Southwest University
2025
Fujian Agriculture and Forestry University
2024-2025
Peking Union Medical College Hospital
2009-2024
National Institute for Radiological Protection
2024
Harbin Medical University
2024
Institute of High Energy Physics
2024
Chinese Academy of Sciences
2024
Wenzhou Medical University
2024
Highlights•Radioresistant cancer cells reprogram metabolic flux toward glutamine anabolism•GS promotes cellular nucleotide synthesis for efficient DNA repair•High expression of GS facilitates growth under radiation stress•GS is transcriptionally regulated by STAT5SummaryRadiation resistance a critical problem in radiotherapy cancer. Radiation kills tumor mainly through causing damage. Thus, efficiency damage repair one the most important factors that limits efficacy. Glutamine...
Diels–Alder reactions are among the most powerful synthetic transformations to construct complex natural products. Despite that increasing of enzymatic intramolecular have been discovered, intermolecular Diels–Alderases rarely described. Here, we report an hetero-Diels–Alder reaction in biosynthesis tropolonic sesquiterpenes and functionally characterize EupfF as first fungal hetero-Diels–Alderase. We demonstrate catalyzed dehydration a hydroxymethyl-containing tropolone (5) generate...
Abstract Heat stress can seriously affect plant growth and development. Ethylene response factors (ERFs) play important roles in development physiological responses. Here, we identified DlERF6, an ERF family transcription factor that promotes heat tolerance Dimocarpus longan. DlERF6 was strongly induced by IAA treatment longan roots. Overexpression of generated abundant, fast-growing hairy roots enhanced promoting biosynthesis reactive oxygen species (ROS) scavenging. Additional assays...
The exact mechanism of the effects hypoxia on proliferation and apoptosis in carcinoma cells is still conflicting. This study investigated variation hypoxia-inducible factor-1α(HIF-1α) expression effect stimulated by cobalt chloride (CoCl2) pancreatic cancer PC-2 cells. were cultured with different concentration (50-200 μmol/L) CoCl2 after 24-120 hours to simulate vitro. was examined MTT assay. cellular morphology observed light inverted microscope transmission electron microscope(EM)....
In addition to serving as a prosthetic group for enzymes and hemoglobin structural component, heme is crucial homeostatic regulator of erythroid cell development function. While lncRNAs modulate diverse physiological pathological cellular processes, their involvement in heme-dependent mechanisms largely unexplored. this study, we elucidated lncRNA (UCA1)-mediated mechanism that regulates metabolism human cells. We discovered UCA1 expression dynamically regulated during maturation, with...
Abstract Drug resistance has always been a huge challenge that should be urgently conquered to improve the efficacy of anticancer drugs. Herein, synergistic Pt(IV) prodrug, Npx‐p p ‐Pt(IV), is proposed, combining dual responsive behavior with drug resistance‐related pathways deactivation. First, ‐Pt(IV) can in situ form supramolecular self‐assembly nanofiber structure on cancer cell surface triggered by phosphatase, which confines tumor and effectively enhances cellular uptake cisplatin,...
Rationale: Tumor energy metabolism has been a well-appreciated target of cancer therapy; however, the change cells between oxidative phosphorylation and glycolysis poses challenge to above.In this study, we constructed an innovative mitochondrion-targeted supramolecular "nano-boat" based on peptide self-assembly for tumor combined chemo-radiotherapy by simultaneously inhibiting dual metabolism.Methods: A lipophilic self-assembled positively charged cyclen were integrated fabricate brand new...
Background The BRAF V600E and telomerase reverse transcriptase (TERT) promoter mutations have been reported in papillary thyroid carcinoma (PTC). aim of this retrospective cross-sectional study was to add further information regarding the prevalence TERT Chinese PTC their clinicopathological associations. Methods We detected mutation 455 patients analyzed association these with several features. Results 343 (75.4%) cases significantly associated older age (p<0.001) conventional subtype (p =...
Human pluripotent stem cells (hPSCs) provide an unlimited source for generating various kinds of functional blood cells. However, efficient strategies large-scale from hPSCs are still lacking, and the mechanism underlying human hematopoiesis remains largely unknown. In this study, we identified myeloid ectopic viral integration site 1 homolog (MEIS1) as a crucial regulator hPSC early hematopoietic differentiation. MEIS1 is vital specification APLNR+ mesoderm progenitors to hemogenic...
The resistance of tumor cells to anticancer drugs has become one the principal causes failure in clinical chemotherapy. To overcome this issue, developing feasible drug delivery systems for effective cancer therapy is urgently needed. In work, we construct an amphiphilic self-delivery system consisting Taxol and tyroservatide (YSV) resistance. carrier-free supramolecular hydrogel composed nanofibers formed by involved ester bond self-hydrolysis process, which high loading efficiency...
β-elemene, a natural sesquiterpene extracted from the essential oils of Curcuma aromatica Salisb, has been shown to be effective against wide range tumors. In this study, antitumor effect β-elemene on human hepatoma cell line, HepG2, and mechanism involved have investigated.MTT assay was used determine growth inhibition HepG2 cells in vitro. Apoptosis were demonstrated by fluorescence microscope with Hoechst 33258 staining flow cytometry Annexin V-FITC/PI double staining. Flow performed...
The radiotherapy modulators used in clinic have disadvantages of high toxicity and low selectivity. For the first time, we situ enzyme-instructed self-assembly (EISA) a peptide derivative (Nap-GDFDFpYSV) to selectively enhance sensitivity cancer cells with alkaline phosphatase (ALP) expression ionizing radiation (IR). Compared vitro pre-assembled control formed by same molecule, assemblies EISA greatly sensitized ALP-high-expressing γ-rays, remarkable sensitizer enhancement ratio. Our...
Abstract Background Neuroendocrine carcinomas of the gastrointestinal tract (GI‐NECs) remain a disease grim prognosis with limited therapeutic options. Their molecular characteristics are still undefined. This study aimed to explore underlying genetic basis and heterogeneity GI‐NECs. Methods Comprehensive genomic analysis using whole‐exome sequencing was performed on 143 formalin‐fixed, paraffin‐embedded samples surgically resected GI‐NEC thorough histological evaluation. Mutational...
Malate dehydrogenase (MDH) is widely present in nature and regulates plant growth development, as well playing essential roles, especially abiotic stress responses. Nevertheless, there no comprehensive knowledge to date on MDH family members rice. In this study, a total of 12 rice were identified through genome-wide analysis divided into three groups the basis their phylogenetic relationship protein-conserved motifs. Evolutionary showed that proteins from rice, maize wheat shared close...
Temperature increases as light intensity rises, but whether signals can be directly linked to high temperature response in plants is unclear. Here, we find that pre-treatment enables survive better under temperature, designated light-induced thermotolerance (LIT). With short-term treatment, induce light-signaling pathway genes and heat shock genes. Blue photoreceptor cryptochrome 1 (CRY1) required for LIT. We also CRY1 physically interacts with the transcription factor A1d (HsfA1d) HsfA1d...
Gastric carcinoma is a common type of malignant tumors and associated with high death rates. The pathogenesis gastric still unclear, increasing evidence shows that many factors contribute to this process. Chromokinesin KIF4 involved in multiple critical cellular processes. Recently, it has become apparent plays crucial suppressive role tumorigenesis. However, the human cancer unclear. In study, we examined expression profiles specimens generated cells stably express GFP-KIF4 fusion protein...
Inhibiting the E3 ubiquitin ligase Idol in a mouse model of Alzheimer’s-like pathology ameliorates disease severity by promoting clearance Aβ peptides microglia.