A5101945788- Cancer Genomics and Diagnostics
- Hearing, Cochlea, Tinnitus, Genetics
- Medical Research and Treatments
- Pancreatic and Hepatic Oncology Research
- Traditional Chinese Medicine Studies
- Neurological Disorders and Treatments
- Pharmacological Effects of Natural Compounds
- Ferroptosis and cancer prognosis
- Sexual function and dysfunction studies
- Genetic factors in colorectal cancer
- Plant-based Medicinal Research
- Head and Neck Cancer Studies
- Diabetic Foot Ulcer Assessment and Management
- Bioinformatics and Genomic Networks
- Cancer-related gene regulation
- Traditional Chinese Medicine Analysis
- Galectins and Cancer Biology
- Facial Nerve Paralysis Treatment and Research
- Bone health and osteoporosis research
- Bioactive natural compounds
- Radiomics and Machine Learning in Medical Imaging
- Colorectal and Anal Carcinomas
- Ideological and Political Education
- Connexins and lens biology
- Regulation of Appetite and Obesity
Sun Yat-sen University
2022-2025
Sun Yat-sen University Cancer Center
2022-2025
State Key Laboratory of Oncology in South China
2022-2025
Peking Union Medical College Hospital
2020-2025
Shandong Provincial Hospital
2022-2025
Shandong University
2022-2025
Xi’an Jiaotong-Liverpool University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2025
Guangdong Provincial Center for Disease Control and Prevention
2025
Beijing University of Chinese Medicine
2025
Abstract Galectin-3 (Gal-3) is a multifunctional protein that has been linked to fibrosis and inflammation in the cardiovascular system. In this study, we examined impact of Gal-3 on patients with arteriogenic erectile dysfunction (A-ED) underlying mechanisms involved. To induce arterial injury, utilized cuffs periaqueductal common iliac arteries Sprague‒Dawley (SD) rats administered high-fat diet co-induce local atherosclerosis. Our results showed successfully developed novel A-ED model was...
Currently, numerous liver injury cases related to a famous Chinese herb- Polygonum Multiflorum (Heshouwu in Chinese) have attracted great attention many countries. Our previous work showed that Heshouwu-induced hepatotoxicity belonged idiosyncratic drug-induced (IDILI). Unfortunately, the components and mechanisms attributed IDILI of Heshouwu are difficult determine thus remain unknown. Attempts explore puzzles, we prepared chloroform (CH)-, ethyl acetate (EA)-, residue (RE) extracts...
Background: Paeonia lactiflora Pall. (PLP), a traditional Chinese herbal medicine, has been used for hepatic disease treatment over thousands of years. In our previous study, PLP was shown to demonstrate therapeutic effect on hepatitis with severe cholestasis. The aim this study evaluate the antioxidative alpha-naphthylisothiocyanate (ANIT)-induced cholestasis by activating NF-E2-related factor 2 (Nrf2) via phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway. Materials and methods:...
Abstract Background Neuroendocrine carcinomas of the gastrointestinal tract (GI‐NECs) remain a disease grim prognosis with limited therapeutic options. Their molecular characteristics are still undefined. This study aimed to explore underlying genetic basis and heterogeneity GI‐NECs. Methods Comprehensive genomic analysis using whole‐exome sequencing was performed on 143 formalin‐fixed, paraffin‐embedded samples surgically resected GI‐NEC thorough histological evaluation. Mutational...
Diabetes mellitus (DM) is a chronic systemic disease characterized by hyperglycemia, with various pathogenic mechanisms. From absolute or relative insulin deficiency, patients DM often demonstrate levels of metabolic disorders. Major clinical manifestations include disorders, vascular lesions, circulatory disturbances and neurologic complications. Along advances in research, reports related tinnitus hearing impairment have increased continuously. Research on auditory system dysfunction has...
In China, approximately 30,000 babies are born with hearing impairment each year. However, the molecular factors causing congenital in Xiamen area of Fujian province have not been evaluated. To provide accurate genetic testing and counseling area, we investigated etiology non-syndromic deafness a deaf population from Xiamen. Unrelated students (n = 155) who attended Special Education School Province were recruited for this study. Three common deafness-related genes, GJB2, SLC26A4,...
Abstract Lung cancer is one of the leading causes all cancer-related deaths. Circulating tumor DNA (ctDNA) released from apoptotic and necrotic cells. Several sensitive techniques have been invented adapted to quantify ctDNA genomic alterations. Applications in lung include early diagnosis detection, prognosis prediction, detecting mutations structural alterations, minimal residual disease, mutational burden, evolution tracking. Compared surgical biopsy radiographic imaging, advantages are...
Abstract Background Cuproptosis is recently emerging as a hot spot in cancer research. However, its role pancreatic adenocarcinoma (PAAD) has not yet been clarified. This study aimed to explore the prognostic and therapeutic implications of cuproptosis-related genes PAAD. Methods Two hundred thirteen PAAD samples from International Cancer Genome Consortium (ICGC) were split into training validation sets ratio 7:3. The Cox regression analyses generated model using ICGC cohort for ( n = 152)...
ABSTRACT Purpose This study aims to evaluate the antitumor activity of neoadjuvant immunochemotherapy in patients with cervical metastatic squamous cell carcinoma unknown primary (CMSCCUP), providing a new idea for its treatment. Method We retrospectively examined medical records from Sun Yat‐sen University Cancer Center identify CMSCCUP July 2020 November 2023. CMSCCUP's diagnoses are based on results biopsy and imaging examination. All received PD‐1 inhibitors combined chemotherapy:...
Pancreatic ductal adenocarcinoma (PDAC) remains treatment refractory. Immunotherapy has achieved success in the of multiple malignancies. However, efficacy immunotherapy PDAC is limited by a lack promising biomarkers. In this research, we aimed to identify robust immune molecular subtypes facilitate prognosis prediction and patient selection for immunotherapy.
J. Sep. Sci. 2016, 39, 4281-4289 DOI: 10.1002/jssc.201600567 Aconite, called tiger and wolf drug, is known in Traditional Chinese Medicine for its strong cardiac effect. In the past, toxins extracted from aconite were used as arrow poisons to kill animals, hence name "wolf's bane." To a certain extent, represents medicinal characteristics of aconite: fierce, wild intractable. The cover picture shows, besides head main element, flow chart our study summarizes topics article.
Colorectal carcinoma (CRC) harboring oncogenic fusions has been reported to be highly enriched in mismatch repair deficient (dMMR) tumors with MLH1 hypermethylation (MLH1me+) and wild-type BRAF RAS. In this study, dMMR CRCs were screened for oncogene using sequential DNA RNA next generation sequencing (NGS).Comprehensive analysis of fusion variants, genetic profiles clinicopathological features fusion-positive was performed. Among 193 consecutive CRCs, 39 cases identified as MLH1me+ BRAF/RAS...