A5103115683- Hearing, Cochlea, Tinnitus, Genetics
- Animal Nutrition and Physiology
- Photosynthetic Processes and Mechanisms
- Plant Stress Responses and Tolerance
- Plant Molecular Biology Research
- Cell Adhesion Molecules Research
- Vitamin D Research Studies
- Cancer-related molecular mechanisms research
- RNA and protein synthesis mechanisms
- Glycosylation and Glycoproteins Research
- Ear Surgery and Otitis Media
- Ubiquitin and proteasome pathways
- Meat and Animal Product Quality
- Peptidase Inhibition and Analysis
- Prenatal Screening and Diagnostics
- Aquaculture Nutrition and Growth
- Congenital heart defects research
- Congenital Ear and Nasal Anomalies
- Cellular Mechanics and Interactions
- Vestibular and auditory disorders
- Signaling Pathways in Disease
- Circular RNAs in diseases
- Seed Germination and Physiology
- Genomic variations and chromosomal abnormalities
- Fetal and Pediatric Neurological Disorders
Fujian Medical University
2015-2025
Fujian Provincial Hospital
2015-2024
Henan Agricultural University
2021-2023
Shangqiu Normal University
2021-2023
Zhejiang Provincial People's Hospital
2022
Hangzhou Medical College
2022
Chinese PLA General Hospital
2021
Nanfang Hospital
2019
Ningxia Medical University
2019
Zhengzhou People's Hospital
2014-2017
In China, approximately 30,000 babies are born with hearing impairment each year. However, the molecular factors causing congenital in Xiamen area of Fujian province have not been evaluated. To provide accurate genetic testing and counseling area, we investigated etiology non-syndromic deafness a deaf population from Xiamen. Unrelated students (n = 155) who attended Special Education School Province were recruited for this study. Three common deafness-related genes, GJB2, SLC26A4,...
Bougainvillea glabra Choisy, a common perennial shrub or climbing vine in tropical and subtropical areas, has significant ornamental ecological value due to its showy floriferous blooms adaptability multiple environmental stresses. In this study, based on PacBio Hi-C sequencing data, we presented the haplotype-resolved, chromosome-level assembled genomes for B. (2n = 34). We obtained two haplotypes with genome size of 2,855,692,602 bp 2,889,511,499 bp, N50 165 Mbp 167 Mbp, both anchored 17...
To assess safety and long-term outcome of stereoelectroencephalography (SEEG)-guided radiofrequency thermocoagulation (RFTC) epileptic foci in eloquent motor areas.We retrospectively reviewed medical charts surgical features 15 patients with drug-resistant focal epilepsy areas treated between 2017 2021. All underwent SEEG-guided RFTC as the first option. General characteristics, SEEG findings, morbidity, seizure after were analyzed to extract potential value for areas.There 12 male 3 female...
Objective: This research aimed to evaluate the effects of age on growth, tibia development, and intestinal calcium (Ca) phosphorus (P) transporter gene expressions in broiler chickens.Methods: A total 224 male Arbor Acres broilers were fed with nutrient-adequate diets reared eight cages (28 per cage). Eight (one cage) selected killed at 5, 10, 15, 20, 25, 30, 35, 40 days age, respectively.Results: Body weight continuously increased chickens from 5 days. The bone weight, ash diameter, length...
Hearing loss (HL) is one of the most common disabilities in world. In industrialized countries, HL occurs 1–2/1,000 newborns, and approximately 60% caused by genetic factors. Next generation sequencing (NGS) has been widely used to identify many candidate genes variants patients with HL, but data are scattered multitudinous studies. It a challenge for scientists, clinicians, biologists easily obtain analyze variant from these Thus, we developed one-stop database HL-related variants, Gene4HL...
SMMC-7721 hepatocellular carcinoma cells (HCC) were incubated with fucosylated glycoproteins that had been isolated from retinoic acid-treated by affinity chromatography. HCC migration was significantly inhibited AAL- and LCA-glycoproteins. Glycopeptides, obtained digestion of the trypsin papain, found to have a similar inhibitory effect on as corresponding glycoproteins. The actions almost abolished after alpha-L-1,3/4- or alpha-L-1,2-fucosidase. Induction chemokines including interleukin-8...
Gastric adenocarcinoma is a predominant disease with latent attribute, high malignancy, and poor prognosis in People's Republic of China. cancer the most common malignant tumor digestive tract. It has been suggested that abnormal expression NEDD9 was associated stage progression metabolism carcinomas. Some authors demonstrated both messenger RNA (mRNA) protein were highly expressed gastric cancer, paired paracancerous atypical hyperplasia tissues correlated lymph node metastasis, depth,...
Two experiments were conducted in this research. Experiment 1 investigated the spatial expression characteristics of calcium (Ca) and phosphorus (P) transporters duodenum, jejunum, ileum 21-day-old broilers provided with adequate nutrient feed. 2 evaluated effects dietary vitamin D3 (VD3) concentration (0, 125, 250, 500, 1,000, 2,000 IU/kg) on growth performance, bone development, gene levels intestinal Ca P 1-21-day-old negative control diet without supplemental VD3. Results experiment...
Capsella bursa-pastoris is well adapted to different environments, especially low temperature suggesting that it possesses relatively strong tolerance against cold stress.Cold ability associated with the accumulation of several cold-induced transcripts.By using a cloning technology, we isolated and sequenced corresponding COR15 gene from C. bursa-pastoris.The putative promoter CbCOR15 contains cis-acting elements have been shown mediate expression cold-responsive genes Arabidopsis...
1. This study investigated the effect of dietary calcium (Ca) levels on growth performance, bone development and Ca transporter gene expression in small intestine broiler chickens.2. On day hatch, 350, Ross 308 male broilers were randomly allotted to one five treatments with replicate pens each 14 birds per pen. Dietary feed 5.0, 7.0, 9.0, 11.0 13.0 g/kg, which 9.0 g/kg was control diet. All diets contained 4.5 non-phytate phosphorus (NPP).3. The increase from 5.0 did not affect performance...
Noninvasive prenatal diagnosis (NIPD) for autosomal recessive nonsyndromic hearing loss (ARNSHL) has been rarely reported until recent years. Additionally, the existing method can not be used challenging genome loci (eg, copy number variations, deletions, inversions, or gene recombinants) on families without proband genotype. This study assessed performance of relative haplotype dosage analysis (RHDO)-based NIPD identifying fetal genotyping in pregnancies at risk ARNSHL. Fifty couples...
Abstract To investigate the possible association of pathogenic mutations SLC26A4 and computerized tomography (CT) phenotypes inner ear, explore feasibility using method gene sequence analysis. A total 155 patients with bilateral hearing loss carrying were further subjected to high-resolution temporal bone CT thyroid B ultrasound tests. The potential relationship between analyzed. As a result, 65 (41.9%, 65/155) carried mutations, 27 cases detected where IVS7-2A>G (55.6%, 15/27) was...
1,25-Dihydroxycholecalciferol (1,25-(OH)2-D3) is the final active product of vitamin D. This study aimed to investigate effects 1,25-(OH)2-D3 on growth performance, bone development, and calcium (Ca) transporter gene expression levels in small intestine broiler chickens. On day hatching, 140 female Ross 308 broilers were randomly allotted into two treatments with five replicates (14 birds per replicate). Two (0 1.25 µg/kg) added basal diet without Results showed that addition µg/kg increased...
X-linked deafness-2 (DFNX2) is cochlear incomplete partition type III (IP-III), one of inner ear malformations characterized by an abnormally wide opening in the bone separating basal turn cochlea from internal auditory canal, fixation stapes and cerebrospinal fluid (CSF) gusher upon stapedectomy or cochleostomy. The causative gene DFNX2 was POU3F4. To investigate genetic causes compare efficiency different sequencing methods, 12 unrelated patients were enrolled present study. Targeted...
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Mutations in the mitochondrial 12S ribosomal RNA gene have been identified to be associated with deafness. Among these, A G transition at position 1555 is one of most common pathogenic mutations hearing loss. In order evaluate allele frequency this mutation infants loss, A1555G was screened 300 deaf children and 100 age‑ sex‑matched healthy subjects. Consequently, 5 patients were identified, whereas absent controls. mutation, only had an obvious family history impairment. Notably, pedigree...