A5042436765- Hippo pathway signaling and YAP/TAZ
- Ubiquitin and proteasome pathways
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- RNA Research and Splicing
- Endoplasmic Reticulum Stress and Disease
- Lipid metabolism and biosynthesis
- Glycosylation and Glycoproteins Research
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Diagnosis and Treatment of Venous Diseases
- Cancer-related Molecular Pathways
- Venous Thromboembolism Diagnosis and Management
- Cancer-related gene regulation
- Obesity, Physical Activity, Diet
- Peripheral Artery Disease Management
- PI3K/AKT/mTOR signaling in cancer
- Maternal and Perinatal Health Interventions
- Cellular transport and secretion
- Cell death mechanisms and regulation
- Wnt/β-catenin signaling in development and cancer
- Maternal Mental Health During Pregnancy and Postpartum
- MicroRNA in disease regulation
Shanghai Jiao Tong University
2016-2025
Lung Institute
2025
Cedars-Sinai Medical Center
2025
International Peace Maternity & Child Health Hospital
2023
Henan Agricultural University
2023
Sumy National Agrarian University
2023
University of Massachusetts Chan Medical School
2012-2013
Tongji University
2008-2012
Ruijin Hospital
2011
General Department of Preventive Medicine
2009
Long non-coding RNA (lncRNA), highly up-regulated in liver cancer (HULC) plays an important role tumorigenesis. Depletion of HULC resulted a significant deregulation several genes involved cancer. Although up-regulation expression hepatocellular carcinoma has been reported, the molecular mechanisms remain unknown. In this study, we used vivo and vitro approaches to characterize cancer-dependent alterations chromatin organization find CREB binding site (encompassing from −67 −53 nt) core...
This study investigates whether the incidence of new-onset diabetes mellitus (DM) is associated with statin use among postmenopausal women participating in Women's Health Initiative (WHI).The WHI recruited 161,808 aged 50 to 79 years at 40 clinical centers across United States from 1993 1998 ongoing follow-up. The current analysis includes data through 2005. Statin was captured enrollment and year 3. Incident DM status determined annually enrollment. Cox proportional hazards models were used...
Abstract O-GlcNAcylation has been implicated in the tumorigenesis of various tissue origins, but its function liver is not clear. Here, we demonstrate that can enhance expression, stability and Yes-associated protein (YAP), downstream transcriptional regulator Hippo pathway a potent oncogenic factor cancer. induces transformative phenotypes cancer cells YAP-dependent manner. An O-GlcNAc site YAP was identified at Thr241, mutating this decreased O-GlcNAcylation, stability, pro-tumorigenic...
The biological functions of N6-methyladenosine (m6A) RNA methylation are mainly dependent on the reader; however, its role in lung tumorigenesis remains unclear. Here, we have demonstrated that m6A reader YT521-B homology domain containing 2 (YTHDC2) is frequently suppressed adenocarcinoma (LUAD). Downregulation YTHDC2 was associated with poor clinical outcome LUAD. decreased a spontaneous LUAD mouse model. Moreover, exhibited antitumor activity human cells. Mechanistically, YTHDC2, via...
Ferroptosis is an outcome of metabolic disorders and closely linked to liver cancer. However, the mechanism underlying fine regulation ferroptosis in cancer remains unclear. Here, we have identified two categories genes: up-regulated factors (FUF) down-regulated (FDF), which stimulate suppress by affecting synthesis GSH. Furthermore, FUF are controlled one transcription factor HIC1, while FDF another HNF4A. Occurrence might depend on histone acetyltransferase KAT2B. Upon stimulation...
Resistance to ferroptosis, a regulated cell death caused by iron-dependent excessive accumulation of lipid peroxides, has recently been linked lung adenocarcinoma (LUAD). Intracellular antioxidant systems are required for protection against ferroptosis. The purpose the present study was investigate whether and how extracellular system desensitizes LUAD cells ferroptosis.Established human fibroblasts MRC-5, WI38, H1650, PC9, H1975, H358, A549, H1299 lines, tumor matched normal adjacent...
Yes-associated protein (YAP), the downstream effecter of Hippo-signaling pathway as well cyclic adenosine monophosphate response element-binding (CREB), has been linked to hepatocarcinogenesis. However, little is known about whether and how YAP CREB interact with each other. In this study, we found that YAP-CREB interaction critical for liver cancer cell survival maintenance transformative phenotypes, both in vitro vivo . Moreover, proteins are highly expressed a subset human samples closely...
Abstract Although Yes-associated protein (YAP) is very important to liver cancer, its nuclear localisation prevents consideration as a promising therapeutic target and diagnostic biomarker. Recently, we reported that the protumourigenic roles of YAP in cancer are indispensable for transcription factor CP2 (TFCP2) Hippo-independent manner; however, proteins act upstream simultaneously control TFCP2 remain unclear. The aim this study was uncover such evaluate whether they potential...
A lack of promising targets leads to poor prognosis in patients with lung adenocarcinoma (LUAD). Therefore, it is urgent identify novel therapeutic targets. The importance the N6-methyladenosine (m6A) RNA modification has been demonstrated various types tumors; however, knowledge m6A-related proteins LUAD still limited. Here, we found that insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3), an m6A reader protein, highly expressed and associated prognosis. IGF2BP3 desensitizes...
Antenatal clinics can expect at least one in five pregnant women to experience mental health problems, especially depression and anxiety. The present study aims estimate the effects of antenatal depressive anxiety symptoms on pregnant, obstetric neonatal outcomes. This was a prospective cohort 527 pregnancies their neonates. Whether were with or without determined by Hospital Anxiety Depression Scale (HADS). All participants followed delivery. prevalence and/or 11.0%. during pregnancy...
Abstract Introduction and objectives The aging population is expected to reach 2 billion by 2050, but the impact of somatic symptom disorder (SSD) on elderly has been insufficiently addressed. We aimed clarify prevalence SSD in China identify physical psychological differences between non-elderly. Methods In this prospective multi-center study, 9020 participants aged (2206 non-elderly adults 6814 adults) from 105 communities Shanghai were included (Assessment Somatic Symptom Chinese...
Epidemiologic studies suggest that hepatocellular carcinoma (HCC) has a strong relationship with diabetes. However, the underlying molecular mechanisms still remain unclear. Here, we demonstrated high glucose (HG), one of main characteristics diabetes, was capable accelerating tumorigenesis in HCC cells. Advanced glycosylation end product–specific receptor (AGER) identified as stimulator during this process. Mechanistically, AGER activated hexosamine biosynthetic pathway, leading to enhanced...
Although YAP-dependent transcription is closely associated with liver tumorigenesis, the mechanism by which YAP maintains its function poorly understood. Here, we show that TFCP2 required for and malignancy. Mechanistically, stimulated via a WW-PSY interaction. also stability inhibiting βTrCP. Notably, genomic co-occupancy of revealed. acts as co-factor stimulates facilitating binding motif (YBF)-containing factors. Interestingly, YAP-TEAD interaction TEAD target gene expression. Finally,...
Abstract Tribbles homolog 2 (TRIB2) is known to boost liver tumorigenesis via regulating Ubiquitin (Ub) proteasome system (UPS). At least two ways are involved, i.e., acts as an adaptor protein modulate ubiquitination functions of certain ubiquitin E3 ligases (E3s) and reduces global Ub levels increasing the proteolysis activity proteasome. Recently, we have identified role TRIB2 relieve oxidative damage reducing availability that essential for subsequent degradation Glutathione peroxidase 4...
Ferroptosis is an iron- and lipid peroxidation-dependent form of regulated cell death. The release labile iron one the important factors affecting sensitivity to ferroptosis. Yes-associated protein (YAP) controls intracellular levels by transcription ferritin heavy chain (FTH) transferrin receptor (TFRC). However, whether YAP regulates metabolism through other target genes remains unknown. Here, we observed that system Xc- inhibitor erastin inhibited binding WW domain PSY motif between...
Abstract Detecting exosomal markers using laser desorption/ionization time‐of‐flight mass spectrometry (LDI‐TOF MS) is a novel approach for examining liquid biopsies of non‐small cell lung cancer (NSCLC) samples. However, LDI‐TOF MS limited by low sensitivity and poor reproducibility when analyzing intact proteins directly. In this report, gold nanoparticles/cellulose nanocrystals (AuNPs/CNC) introduced as the matrix direct analysis in NSCLC serum exosomes. AuNPs/CNC with “dual dispersion”...
To investigate the prevalence of anxiety and depression pregnant women during prenatal period, provide information for further epidemiological study.With ethics committee approval, a total 527 recruited from Department Obstetrics Gynecology, Tongji University Medical School were selected at four hospitals that affiliated to University. By applying self-designed questionnaire hospital (HAD) scale, we evaluated anxious depressive symptoms in these women.The rates Chinese period 6.8% 4.8%,...
CD166/ALCAM plays an important role in tumor aggression and progression as well protecting cancer cells against apoptosis autophagy. However, the mechanism by which pro-cell death signals control CD166 expression remains unclear. Here we show that following serum deprivation (SD), upregulation of protein is shorter than mRNA. Molecular analysis revealed both miR-9-1 two novel NF-κB target genes hepatoma cells. In vivo activation translocation P50/P65 hetero-dimer into nucleus phosphorylation...
To examine determinants of racial/ethnic differences in diabetes incidence among postmenopausal women participating the Women's Health Initiative.Data on race/ethnicity, baseline prevalence, and incident were obtained from 158,833 recruited 1993-1998 followed through August 2009. The relationship between other potential risk factors, was estimated using Cox proportional hazards models which hazard ratios (HRs) 95% CIs computed.Participants aged 63 years average at baseline. distribution...
Tribbles homolog 2 (TRIB2) is specifically regulated by Wnt signaling in liver cancer cells but not colon cells. However, whether and how TRIB2 regulates remains unclear. Here, we report that negatively activity through a reduction protein stability of TCF4 β‐Catenin. Mechanistically, associated‐ubiquitin E3 ligases beta‐transducin repeat‐containing ubiquitin ligase (β‐TrCP), COP1 Smad ubiquitination regulatory factor 1 (Smurf1) reduced TCF4/β‐Catenin expression, these effects could be...
Abstract The regulation of homeostasis in the Ubiquitin (Ub) proteasome system (UPS) is likely to be important for development liver cancer. Tribbles homolog 2 (TRIB2) known affect Ub E3 ligases (E3s) However, whether TRIB2 regulates UPS other ways and relevant mechanisms are still unknown. Here, we reveal that decreased levels largely by stimulating degradation Ub. In proteasome, 20S subunit beta 5 (PSMB5) was critical function TRIB2, although it did not directly interact with TRIB2. poly...