A5101878838- Renal Transplantation Outcomes and Treatments
- COVID-19 Clinical Research Studies
- Hepatitis C virus research
- Glycosylation and Glycoproteins Research
- Cell Adhesion Molecules Research
- RNA Research and Splicing
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Protein Tyrosine Phosphatases
- RNA modifications and cancer
- Lipid metabolism and disorders
- SARS-CoV-2 and COVID-19 Research
- Cancer Genomics and Diagnostics
- HIV/AIDS drug development and treatment
- Connective tissue disorders research
- Cancer-related molecular mechanisms research
- Long-Term Effects of COVID-19
- Antimicrobial Peptides and Activities
- Neurological Complications and Syndromes
- Cancer Mechanisms and Therapy
- Pneumocystis jirovecii pneumonia detection and treatment
- Cancer Research and Treatments
- Ferroptosis and cancer prognosis
- Transplantation: Methods and Outcomes
- Glutathione Transferases and Polymorphisms
Ruijin Hospital
2009-2024
Shanghai Jiao Tong University
2009-2024
University of Toledo
2012
Tongji University
2011
Services Hospital
2010
Universitat de Barcelona
2010
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2010
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2010
Medical University of Białystok
2010
University of Bologna
2009
Long non-coding RNA (lncRNA), highly up-regulated in liver cancer (HULC) plays an important role tumorigenesis. Depletion of HULC resulted a significant deregulation several genes involved cancer. Although up-regulation expression hepatocellular carcinoma has been reported, the molecular mechanisms remain unknown. In this study, we used vivo and vitro approaches to characterize cancer-dependent alterations chromatin organization find CREB binding site (encompassing from −67 −53 nt) core...
AIM:To investigate the role of subjective global assessment (SGA) in nutritional and outcome prediction Chinese patients with gastrointestinal cancer.METHODS: A total 751 diagnosed cancer between August 2004 2006 were enrolled this study.Within 72 h after admission, SGA, anthropometric parameters, laboratory tests used to assess status each patient.The variables including hospital stay, complications, in-hospital medical expenditure also obtained. RESULTS:Based on results 389 (51.8%), 332...
Abstract Background Proteins functioning in the same biological pathway tend to be transcriptionally co-regulated or form protein-protein interactions (PPI). Multiple spatially and temporally regulated events are coordinated during mitosis achieve faithful chromosome segregation. The molecular players participating regulation still being unravelled experimentally using silico methods. Results An extensive literature review has led a compilation of 196 human centromere/kinetochore proteins,...
CD166/ALCAM plays an important role in tumor aggression and progression as well protecting cancer cells against apoptosis autophagy. However, the mechanism by which pro-cell death signals control CD166 expression remains unclear. Here we show that following serum deprivation (SD), upregulation of protein is shorter than mRNA. Molecular analysis revealed both miR-9-1 two novel NF-κB target genes hepatoma cells. In vivo activation translocation P50/P65 hetero-dimer into nucleus phosphorylation...
Chromosome is the basic framework for eukaryotic cells to store genetic information, but certain genes exist in circulation, such as extrachromosomal circular DNA (eccDNA). The unique characteristics and structure of eccDNA provide a new vision on early diagnosis cancer; however, whether contributes progression lung cancer remains unclear.We performed next-generation sequencing (NGS) analysis from plasma 6 adenocarcinoma (LUAD) patients. data healthy people were obtained public available...
The objective of this study is to investigate the correlation between methods high-performance liquid chromatography (HPLC) and enzyme multiplied immunoassay technology (EMIT) for determination total mycophenolic acid (tMPA) free (fMPA) concentration pharmacokinetics fMPA in Chinese liver transplant recipients. An HPLC method with fluorometric detection an EMIT assay were established determine plasma ultrafiltrates. Pharmacokinetic parameters tMPA 51 patients estimated. calibration range was...
Background: Iron metabolism related genes participate in cell proliferation, growth, and redox cycling multiple cancers. Limited studies have revealed the roles clinical significance of iron pathogenesis prognosis lung cancer. Methods: A total 119 were extracted from MSigDB database their prognostic values determined The Cancer Genome Atlas adenocarcinoma (TCGA-LUAD) dataset Gene Expression Profiling Interactive Analysis 2 (GEPIA 2) database. Immunohistochemistry technique correlations with...
PTPRA is reported to be involved in cancer development and progression through activating the Src family kinase (SFK) signaling pathways, however, roles of squamous cell lung (SCC) are unclear. The purpose this study was clarify clinical relevance biological SCC. We found that upregulated compared matched normal tissues at mRNA (N=20, P=0.004) protein expression levels (N=75, P<0.001). Notably, high level significantly correlated with poorer prognosis 675 SCC patients from Kaplan-Meier...
Vitamin D, an essential nutrient and a pleiotropic steroid hormone, has been reported to be associated with the risk severity in patients infected Coronavirus Disease-2019 (COVID-19). The role of vitamin D predicting clinical outcome for COVID-19 is unknown. Here, we aimed determine prognostic value plasma 25(OH)D level patients.A total 158 novel Omicron variants Shanghai were recruited this study categorized into three groups by tertile levels 25(OH)D. Plasma was determined along routine...
Nuclear Factor Erythroid 2-Related 2 (NRF2) is important for the expression of genes associated with oxidative stress. The levels NRF2 are controlled by Kelch-like ECH-associated protein 1 (KEAP1)-dependent degradation. Although stress known to suppress KEAP1 activity stabilize NRF2, mechanism this control unclear. Here, we identify that modified SUMO1 at lysine residue position 39 (K39). Arginine replacement (K39R) in did not affect its stability, subcellular localization, or dimerization...
Protein tyrosine phosphatase (PTP)‑α regulates the phosphorylation of focal adhesion kinase (FAK), which is important in cellular signal transduction and integration proteins. It has been demonstrated that a FAK‑Del33 mutation (deletion exon 33; KF437463) breast cancer tissues cell migration through FAK/Src signaling activation. However, detailed pathway for Src activation with remains to be elucidated. The present study used retroviral expression system examine changes PTPα affected by...
The widespread coronavirus disease 2019 (COVID-19) outbreak impacted the mental health of infected patients admitted to Fangcang shelter hospital a large-scale, temporary structure converted from existing public venues isolate with mild or moderate symptoms COVID-19 infection.This study aimed investigate risk factors new pharmacological perspective based on psychiatric drug consumption rather than questionnaires for first time.We summarised medical information and analysed prevalence...
This study investigated the relationship between pharmacokinetics and pharmacodynamics of mycophenolic acid (MPA) in liver transplant patients receiving mycophenolate mofetil (MMF). Total free plasma MPA concentrations were determined by high-performance liquid chromatography before MMF dose at 0.5, 1, 1.5, 2, 4, 6, 8, 10, 12 hours after dosing 27 patients. The inhibitory capacity serum on proliferation CEM cells was monitored 0, 2 hours. concentration (C(0h), C(1h), C(2h)) area under...
By the end of 2022, China had made a pivotal decision to optimize COVID-19 policy. The dominant Omicron variant in at that time was highly transmissible. In this study, we aimed evaluate real-world safety and efficacy tixagevimab cilgavimab against background China.
Staphylococcus aureus (S. aureus) pneumonia has become an increasingly important public health problem. Recent evidence suggests that epigenetic modifications are critical in the host immune defence against pathogen infection. In this study, we found S. infection induces expression of histone deacetylase 6 (HDAC6) a dose-dependent manner. Furthermore, by using mouse model, showed HDAC6 inhibitor, tubastatin A, demonstrates protective effect pneumonia, decreasing mortality and destruction...
This study aimed to investigate the real-world use and clinical outcomes of tixagevimab/cilgavimab in China during Omicron outbreak late 2022.