A5100386382- Bladder and Urothelial Cancer Treatments
- Epigenetics and DNA Methylation
- Prostate Cancer Treatment and Research
- Ferroptosis and cancer prognosis
- Prostate Cancer Diagnosis and Treatment
- Urinary and Genital Oncology Studies
- Cancer-related molecular mechanisms research
- Urological Disorders and Treatments
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Renal cell carcinoma treatment
- PARP inhibition in cancer therapy
- Cancer-related gene regulation
- Pediatric Urology and Nephrology Studies
- Kidney Stones and Urolithiasis Treatments
- Plant Molecular Biology Research
- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- Lung Cancer Treatments and Mutations
- Immunotherapy and Immune Responses
- Cancer, Lipids, and Metabolism
- Tissue Engineering and Regenerative Medicine
- Hepatocellular Carcinoma Treatment and Prognosis
- Renal and related cancers
- Immune cells in cancer
China Pharmaceutical University
2020-2025
Beijing University of Agriculture
2025
Ministry of Agriculture and Rural Affairs
2025
The First Affiliated Hospital, Sun Yat-sen University
2025
Sun Yat-sen University
2025
Zhujiang Hospital
2015-2024
Southern Medical University
2015-2024
Fourth Affiliated Hospital of Guangxi Medical University
2024
Jiangsu Academy of Agricultural Sciences
2018-2024
Institute of Pomology
2018-2024
Two draft sequences of Gossypium hirsutum, the most widely cultivated cotton species, provide insights into genome structure, rearrangement, gene evolution and fiber biology. Upland is a model for polyploid crop domestication transgenic improvement. Here we sequenced allotetraploid hirsutum L. acc. TM-1 by integrating whole-genome shotgun reads, bacterial artificial chromosome (BAC)-end genotype-by-sequencing genetic maps. We assembled annotated 32,032 A-subgenome genes 34,402 D-subgenome...
<h3>Importance</h3> Laparoscopic distal gastrectomy is accepted as a more effective approach to conventional open for early-stage gastric cancer. However, efficacy locally advanced cancer remains uncertain. <h3>Objective</h3> To compare 3-year disease-free survival patients with after laparoscopic or gastrectomy. <h3>Design, Setting, and Patients</h3> The study was noninferiority, open-label, randomized clinical trial at 14 centers in China. A total of 1056 eligible stage T2, T3, T4a without...
BACKGROUNDCurrent methods for the detection and surveillance of bladder cancer (BCa) are often invasive and/or possess suboptimal sensitivity specificity, especially in early-stage, minimal, residual tumors.METHODSWe developed an efficient method, termed utMeMA, urine tumor DNA methylation at multiple genomic regions by MassARRAY. We identified BCa-specific markers combined analyses cohorts from Sun Yat-sen Memorial Hospital (SYSMH), The Cancer Genome Atlas (TCGA), Gene Expression Omnibus...
<h3>Importance</h3> It is not clear whether laparoscopic and open distal gastrectomy produce similar outcomes among patients with locally advanced gastric cancer. Data from a multicenter, randomized clinical trial (Chinese Laparoscopic Gastrointestinal Surgical Study [CLASS]–01) showed that did result in inferior disease-free survival at 3 years compared gastrectomy. <h3>Objective</h3> To report 5-year overall data the CLASS-01 of vs <h3>Design, Setting, Patients</h3> This was...
Programmed cell death 1 (PD-1) is widely expressed in tumor-infiltrating lymphocytes (TILs) of triple-negative breast cancer (TNBC). As a dominant inhibitory immune checkpoint (ICP) receptor, surface PD-1 well-known to transduce negative signaling effector T activity during cell-cell contact. However, despite its well-documented effects, higher expression TILs significantly associated with longer survival TNBC patients. This phenomenon raises an interesting question whether harbors positive...
The incidence of prostate cancer (PCa) within Asian population used to be much lower than in the Western population; however, recent years and mortality rate PCa some countries have grown rapidly. This collaborative report summarized latest epidemiology information, risk factors, racial differences diagnosis, current status new trends surgery management novel agents for castration-resistant cancer. We believe such information would helpful clinical decision making urologists oncologists,...
Cancer stem cells are considered responsible for many important aspects of tumors such as their self-renewal, tumor-initiating, drug-resistance and metastasis. However, the genetic basis origination human bladder cancer (BCSCs) remains unknown. Here, we conducted single-cell sequencing on 59 including BCSCs, non-stem (BCNSCs), epithelial (BESCs) (BENSCs) from three (BC) specimens. Specifically, BCSCs demonstrate clonal homogeneity suggest origin BESCs or BCNSCs through phylogenetic analysis....
TGF-β1-induced epithelial-mesenchymal transition (EMT) has been proved to be associated with metastasis of breast cancer cells. We attempted detect a novel mechanism that microRNAs mediated the EMT in process metastasis. Here we reported expression miR-23a was higher cells high ability and patients lymph node treatment TGF-β1 significantly upregulated found by post-transcriptionally Smads directly bound RNA Smad binding element (R-SBE) miR-23a. Functional studies showed inhibition suppressed...
<b><i>Objective:</i></b> Obesity-related disease risks may vary depending on whether the subject has metabolically healthy obesity (MHO) or unhealthy (MUO). At least 5 definitions/criteria of and metabolic disorders have been documented in literature, yielding uncertainties a reliable international comparison phenotype prevalence. This report aims to compare differences MHO MUO prevalence according most frequently used definitions.<b><i>...
Background: Necroptosis, a cell death of caspase-independence, plays pivotal role in cancer biological regulation. Although necroptosis is closely associated with oncogenesis, metastasis, and immunity, there remains lack studies determining the necroptosis-related genes (NRGs) highly immunogenic type, kidney renal clear carcinoma (KIRC). Methods: The information clinicopathology transcriptome was extracted from TCGA database. Following division into train test cohorts, three-NRGs (TLR3,...
Abstract Purinergic signaling plays a causal role in the pathogenesis of inflammatory bowel disease. Among purinoceptors, only P2Y 14 R is positively correlated with score mucosal biopsies ulcerative colitis patients, nevertheless, remains unclear. Here, based on over-expressions intestinal epithelium mice experimental colitis, we find that male lacking epithelial cells exhibit less injury induced by dextran sulfate sodium. Mechanistically, deletion limits transcriptional activity...
Acute liver failure (ALF) is lack of broadly approved therapeutic strategy except transplantation. As a glycogen metabolic intermediate, UDP-glucose (UDP-G) has been considered to accelerate repairment. Nevertheless, the role UDP-G and its receptor P2Y purinoceptor 14 (P2Y14R) in ALF remains unknown. The present study aims investigate underlying mechanisms UDP-G/P2Y14R axis ALF. In this study, hepatic P2Y14R significantly increased TAA-induced partial hepatectomy-induced ALF, while knockout...
This study developed composite microspheres from orange peel biochar pyrolyzed by 300 °C-900 °C and sodium alginate to address the removal of crystal violet (CV). Biochar was at different temperatures, 800 (B800) based‑sodium (BS800) showed highest adsorption performance, in which, specific surface area pore size B800 387.47 m2/g 1.66 nm, respectively. Adsorption primarily driven chemical mechanisms, as confirmed kinetic isothermal models, while thermodynamic analysis revealed process be...
Background: Recent studies indicate that long noncoding RNAs (lncRNAs) play a key role in the control of cellular processes such as proliferation, metastasis, and differentiation. The lncRNA dysregulation has been identified all types cancer. We previously found AK126698 suppresses cisplatin resistance A549 cells through Wnt/β-catenin signaling pathway. However, clinical significance molecular mechanisms which it regulates cancer cell proliferation migration are largely unknown. Methods:...
Abstract A small population of cells with stem cell‐like properties in prostate cancer ( PC a), called (Pr CSC s) or stemness‐high cells, displays highly tumorigenic and metastatic features may be responsible for the therapy resistance. molecule, napabucasin BBI 608), recently have been identified suppression a variety cancers. However, effects on as well Pr s isolated from not yet defined. The effect cell proliferation, colony formation, migration vitro were measured by MTS , formation...
Glaucocalyxin A (GLA), a major component isolated from Rabdosia japonica, has been proven to show anti-bacterial and anti-tumor biological characteristics according previous studies.However, its potential effect on bladder cancer remains unknown.The present research aims investigate the underlying mechanism in treating vivo vitro.Cell proliferation was analyzed by CCK-8 assay colony formation.Flow cytometry used measure cell cycle distribution apoptosis.The expressions of apoptosis-related...
Abstract PARP1 inhibitors (PARPi) are currently used in the clinic for treatment of ovarian and breast cancers, yet their therapeutic efficacy against hepatocellular carcinoma (HCC) has been disappointing. To ensure PARPi HCC, a disease often diagnosed at intermediate to advanced stages with no effective options, it is critical identify not only biomarkers predict resistance but also rational treatments overcome this. Here, we report that heterodimer EGFR MET interacts phosphorylates Y907...
Abstract Nod-like receptor protein 3 (NLRP3)-mediated pyroptosis has a causal role in the pathogenesis of gout. P2Y 14 (P2Y R) distributed immune cells including macrophages is Gi-coupled that inhibits synthesis cAMP, which been regarded as potential regulator inflammatory response. Nevertheless, R MSU-induced involved acute gouty arthritis still unclear. In our present study, knockout R-KO) disrupted histopathologic changes rat synoviums, accompanied with significant inhibition pyroptotic...
// Yongqiang Wang 1, 2, * , Yuan Yu 3, Rui Ye Duo Zhang Qiaoling Li 3 Dan An Lu Fang 4 Youcheng Lin 5 Yong Hou Abai Xu Fu 6 Wei Xin Chen 1 Mingwei Meng Huiling Jiang 7 Chuanxia 8 Pei Dong Chong 9 Jun 10 Guosheng Yang Chunxiao Liu Zhiming Cai 11 Fangjian Zhou Song Wu Department of Urology, Sun Yat-sen University Cancer Center, Collaborative Innovation Center for Medicine, State Key Laboratory Oncology in South China, Guangzhou, 510060, China 2 The Affiliated Luohu Hospital Shenzhen...
Abstract The phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) pathway has been identified as an important in renal cell carcinoma (RCC). We have reported a nonsense mutation PIK3R1 , which encodes the regulatory subunit of PI3K, metastatic RCC (mRCC), while was absent corresponding primary (pRCC). To identify function RCC, we examined its expression normal kidney, pRCC and mRCC by immunohistochemistry real-time polymerase chain reaction. significantly decreased further reduced...