A5102745832- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA modifications and cancer
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Cancer-related gene regulation
- Monoclonal and Polyclonal Antibodies Research
- Immune cells in cancer
- Immune Cell Function and Interaction
- Ferroptosis and cancer prognosis
- Chemokine receptors and signaling
- Enzyme function and inhibition
- vaccines and immunoinformatics approaches
- Virus-based gene therapy research
- Toxin Mechanisms and Immunotoxins
- NF-κB Signaling Pathways
- melanin and skin pigmentation
- Cancer Research and Treatments
- Endoplasmic Reticulum Stress and Disease
- Acne and Rosacea Treatments and Effects
- Galectins and Cancer Biology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer, Hypoxia, and Metabolism
- Musculoskeletal synovial abnormalities and treatments
Fudan University
2020-2023
Health Commission of Anhui Province
2023
Linyi People's Hospital
2017-2023
Xuzhou Medical College
2023
First Affiliated Hospital of Xinjiang Medical University
2023
Xinjiang Medical University
2023
Minhang District Central Hospital
2020-2023
Hebei Medical University
2020-2022
Second Hospital of Hebei Medical University
2020-2022
Central South University
2019-2022
Abstract Arecoline, a major alkaloid within areca nut extract, is recognized as the primary active carcinogen promoting oral squamous cell carcinoma (OSCC) pathological development. Dysregulation of N6‐methyladenosine (m6A) methyltransferase components (e.g., Fat mass and obesity‐associated protein [FTO] methyltransferase‐like 3 [METTL3]) are closely associated with multiple cancer progression, including cancer. However, biological function role FTO in arecoline‐induced largely unknown. We...
// Fengyuan Che 1, 2, 3 , Jiawei Yin 2 Yanchun Quan Xiaoli Xie Xueyuan Heng 4 Yifeng Du 1 and Lijuan Wang 5 Department of Neurology, Shandong Provincial Hospital, University, Jinan, Province, China Central Laboratory, Linyi People's Linyi, Neurosurgery, Hematology, Correspondence to: Wang, email: wanglj730@163.com Du, duyf69@163.com Keywords: glioma cancer stem cells, CD133-positive, toll-like receptor 4, cytotoxic T lymphocyte, immune evasion Received: March 04, 2017 Accepted: May 22,...
The most common type of endocrine disease is 2 diabetes mellitus (T2DM); genetic factors contribute to the development T2DM.In this study, we investigated role Leu53Leu, Arg213Gly, and Ala40Thr polymorphisms in extracellular superoxide dismutase (EC-SOD) gene T2DM a Chinese population.DNA was extracted from peripheral blood samples obtained 256 patients 324 control subjects recruited our hospital between January 2013 March 2015.DNA genotyped by polymerase chain reaction-restriction fragment...
Abstract Background Key lncRNAs associated with the malignant progression of oral submucous fibrosis (OSF) to squamous cell carcinoma (OSCC) were identified. Methods sequential changes from normal mucosa (NOM) OSF OSCC identified based on GEO database. Kaplan–Meier analysis was used screen related prognosis. Cox regression validate independent prognostic value. qPCR confirm expression candidate lncRNAs. Gene set enrichment (GSEA), nucleocytoplasmic separation assay, fluorescence in situ...
Brucellosis has become a global zoonotic disease, seriously endangering the health of people all over world. Vaccination is an effective strategy for protection against Brucella infection in livestock developed countries. However, current vaccines are pathogenic to humans and pregnant animals, which limits their use. Therefore, it very important improve safety immune vaccine. In this study, different bioinformatics approaches were carried out predict physicochemical properties, T/B epitope,...
Lung squamous cell carcinoma (LSCC) exhibits a number of similarities with lung adenocarcinoma (LA) in terms copy alterations. However, compared LA, the range genetic alterations LSCC is less understood. In present study, large‑scale literature‑based search LA‑associated genes and LSCC‑associated was performed to identify basis common these two diseases. For each genes, mega‑analysis test its expression variations using 11 RNA datasets, significant identified statistical analysis....
Colorectal cancer (CRC) is a malignant tumor with high morbidity and mortality, but there still no recognized prognostic prediction model to better predict intervene its prognosis. Our aim establish novel microRNA (miRNA) signature identify hub target genes for simply accurately predicting survival risk CRC patients provide therapeutic targets.The miRNA expression profiles along clinical data of 512 were downloaded from the Cancer Genome Atlas (TCGA) database randomly divided into training...
Abstract Background Colorectal carcinoma, primarily colorectal adenocarcinoma (CRA), is one of the most common malignancies, ranking third, while contributing second cause cancer death in world. MicroRNAs, a type non-coding RNA, play an important role regulating cancer-related cell biology. To simply and accurately predict survival risk for CRA patients, we identified novel seven-miRNA signature. The microRNA (miRNA) expression profiles along with clinical data 512 patients were downloaded...
Background and aims Hermansky-Pudlak syndrome (HPS) is an autosomal recessive disorder characterized by oculocutaneous albinism (OCA) platelet storage pool deficiency. The HPS-2 subtype distinguished neutropenia, little known about its periodontal phenotype in adolescents. AP3B1 the causative gene for HPS-2. A 13-year-old Chinese girl presented to our department suffering from gingival bleeding tooth mobility. Her dental history was otherwise unremarkable. Suspecting some systemic diseases...
Objective To screen out the microRNAs (miRNAs) associated with prognosis of hepatocellular carcinoma (HCC) through data mining miRNA transcriptome HCC downloaded from The Cancer Genome Atlas (TCGA) database, to establish a risk score model, and investigate its value in predicting HCC. Methods The expression clinical samples were TCGA database R language was used differentially expressed miRNAs between tissue adjacent tissue, which randomly divided into training set testing after being...
Abstract Objective To explore the biological role of miR-206 in inhibiting proliferation and invasion estrogen-induced ER-α36 positive gastric cancer cells its related mechanisms. Methods MTT tranwell assays were used to detect BGC-823 under different concentrations time ER stimulation. RT-PCR was effect stimulation on content cells. mimics transfected into cell invasion; luciferase reporter assay determine whether targets 3’-untranslated region CDK14-encoding gene (3’ -UTR). Results We...
Chronic liver diseases have various etiologies and often poor long-term prognosis in clinical practice. Y-box binding protein-1 (YB-1) is a multifunctional protein, in-depth studies recent found that it plays key role the development progression of chronic such as fibrosis hepatocellular carcinoma (HCC). This article summarizes YB-1 fibrosis, HCC (proliferation, apoptosis, metastasis, prognosis, drug resistance), failure, so to provide theoretical basis for diagnosis treatment diseases.