A5020286352- Histone Deacetylase Inhibitors Research
- Epigenetics and DNA Methylation
- Carbohydrate Chemistry and Synthesis
- Diet, Metabolism, and Disease
- Protein Degradation and Inhibitors
- Traditional Chinese Medicine Analysis
- Glycosylation and Glycoproteins Research
- Plant chemical constituents analysis
- Plant biochemistry and biosynthesis
- Advanced Polymer Synthesis and Characterization
- Catalysis for Biomass Conversion
- Cancer-related molecular mechanisms research
- Glioma Diagnosis and Treatment
- Genomics and Phylogenetic Studies
- Metabolomics and Mass Spectrometry Studies
- Polymer Surface Interaction Studies
- Ferroptosis and cancer prognosis
- Neurological Disease Mechanisms and Treatments
- RNA modifications and cancer
- Microbial Metabolism and Applications
- Potato Plant Research
- Phytochemistry and Bioactivity Studies
- Immune cells in cancer
- Marine Sponges and Natural Products
- Proteoglycans and glycosaminoglycans research
Agricultural Genomics Institute at Shenzhen
2022-2025
Chinese Academy of Agricultural Sciences
2022-2025
Ministry of Agriculture and Rural Affairs
2024-2025
Linyi People's Hospital
2017-2024
Linyi University
2021-2022
Zhengzhou University
2022
Shandong University
2018-2021
Tianjin Medical University
2014-2018
Georgia State University
2015-2016
Butylphthalide is one of the first-line drugs for ischemic stroke therapy, while no biosynthetic enzyme butylphthalide has been reported. Here, we present a haplotype-resolved genome
Studies of rare ketoses have been hampered by a lack efficient preparation methods. A convenient, efficient, and cost-effective platform for the facile synthesis is described. This method enables difficult-to-access ketopentoses ketohexoses from common inexpensive starting materials with high yield purity without need tedious isomer separation step.
Long non-coding RNAs (lncRNAs), microRNAs (miRNAs or miRs), and genes are emerging players in cancer progression. In the present study, we explored roles interactions of oncogenic lncRNA small nucleolar RNA host gene 1 (SNHG1), miR-376, forkhead box protein K1 (FOXK1), Snail hepatocellular carcinoma (HCC). Expression SNHG1, FOXK1 HCC was characterized clinical tissues 75 patients with HCC. The between SNHG1 miR-376 were predicted confirmed by dual-luciferase reporter immunoprecipitation...
Aberrant enzymatic activities or expression profiles of epigenetic regulations are therapeutic targets for cancers. Among these, histone 3 lysine 9 methylation (H3K9Me2) and global de-acetylation on proteins associated with multiple cancer phenotypes including leukemia, prostatic carcinoma, hepatocellular carcinoma pulmonary carcinoma. Here, we report the discovery first small molecule capable acting as a dual inhibitor targeting both G9a HDAC. Our structure based design, synthesis,...
SUMMARY Acacetin, a flavonoid compound, possesses wide range of pharmacological effects, including antimicrobial, immune regulation, and anticancer effects. Some key steps in its biosynthetic pathway were largely unknown flowering plants. Here, we present the first haplotype‐resolved genome Chrysanthemum indicum , whose dried flowers contain abundant flavonoids have been utilized as traditional Chinese medicine. Various phylogenetic analyses revealed almost equal proportion three tree...
Abstract Angelica L. has attracted global interest for its traditional medicinal uses and commercial values. However, few studies have focused on the metabolomic differences among species. In this study, widely targeted metabolomics based gas chromatography-tandem mass spectrometry was employed to analyze metabolomes of four species ( sinensis (Oliv.) Diels A. ), biserrata (R.H.Shan & Yuan) C.Q.Yuan R.H.Shan dahurica (Hoffm.) Benth. Hook.f. ex Franch. Sav. ) keiskei Koidz. )). A total...
Abstract Furocoumarins (FCs), important natural compounds with biodefense roles and pharmacological activities, are notably abundant in medicinal plant Angelica dahurica . However, its accumulation patterns over development stages FC-enriched tissue, biosynthetic pathways, regulatory mechanisms A. remain elusive. Here, we quantified the concentration dynamics of 17 coumarins across six developmental root found a gradual decrease FC as roots develop. Using de-novo assembled chromosome-level...
Abstract Furocoumarins (FCs) are crucial natural products playing a dual role as plant defense molecules and pharmacologically active substances. Angelica dahurica is renowned herb with diverse abundant FCs. However, the accumulation pattern over developmental stages, biosynthesis pathway regulatory mechanisms of FCs in A. remain elusive, hindering production via synthetic biology approaches. Here, we constructed chromosome-level reference genome for quantified content dynamics 17 coumarins...
α‐Glucosidase is known to catalyze the digestion of carbohydrates and release free glucose into digestive tract. Protein tyrosine phosphatase 1B ( PTP 1B) engaged in dephosphorylation insulin receptor regulation sensitivity. Therefore, dual antagonists by targeting both α‐glucosidase may be potential candidates for type 2 diabetes therapy. In this work, three series novel N ‐aryl‐ ω ‐(benzoazol‐2‐yl)‐sulfanylalkanamides were synthesized assayed their inhibitory activities, respectively....
Abstract Studies of rare ketoses have been hampered by a lack efficient preparation methods. A convenient, efficient, and cost‐effective platform for the facile synthesis is described. This method enables difficult‐to‐access ketopentoses ketohexoses from common inexpensive starting materials with high yield purity without need tedious isomer separation step.
O-GlcNAcase (OGA) is the only enzyme responsible for removing N-acetyl glucosamine (GlcNAc) attached to serine and threonine residues on proteins. This plays a key role in O-GlcNAc metabolism. However, structural features of sugar moiety recognized by human OGA (hOGA) remain unclear. In this study, set glycopeptides with modifications GlcNAc residue were prepared recombinant full-length OGT-catalyzed reaction using chemoenzymatically synthesized UDP-GlcNAc derivatives. The resulting used...
The functional nanocomposite coatings are easily lose their function with structure damages caused by external forces during working, which severely restrict further applications in biomedical. Thus, designing a multifunction coating capable of healing and maintaining its functions is urgently desired. Here, based on the excellent heterogeneous self-healing property between poly(ethyleneimine)/poly(acrylic acid) (bPEI/PAA) polyelectrolyte substrate shell layer (Ag-bPEI/PAA) Ag-bPEI/[email...
Abstract Butylphthalide, one type of phthalides, is the first-line drugs for ischemic stroke therapy, while no enzyme involved in its biosynthesis pathway has been reported. Here, we present first haplotype-resolved genome Ligusticum chuanxiong Hort., a long-cultivated and phthalide-rich medicinal plant Apiaceae. Based on comprehensive candidate gene screening, four Fe (II)- 2-oxoglutarate-dependent dioxygenases (2OGDs) two CYPs were mined further biochemically verified as phthalide C-4/C-5...
Abstract Multiple myeloma (MM) is a common malignant hematologic neoplasm, and the involvement of epigenetic modifications in its development drug resistance has received widespread attention. Ferroptosis, new ferroptosis-dependent programmed death mode, closely associated with MM. The effects DCG066 on viability MM cell lines ARH-77 RPMI-8226 cells were detected by MTT assay Calcein-AM/PI live/dead Cell Assay Kit; intracellular level Reactive Oxygen Species (ROS) was flow cytometry; iron...