A5101585053- Antifungal resistance and susceptibility
- Neural and Behavioral Psychology Studies
- Fungal Infections and Studies
- Attention Deficit Hyperactivity Disorder
- Urinary Bladder and Prostate Research
- Kidney Stones and Urolithiasis Treatments
- Bladder and Urothelial Cancer Treatments
- Pediatric Urology and Nephrology Studies
- Prostate Cancer Diagnosis and Treatment
- EEG and Brain-Computer Interfaces
- Urological Disorders and Treatments
- Cancer and Skin Lesions
- Tissue Engineering and Regenerative Medicine
- Infectious Diseases and Mycology
- Ureteral procedures and complications
- Foot and Ankle Surgery
- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
- Viral Infectious Diseases and Gene Expression in Insects
- Adrenal and Paraganglionic Tumors
- Hedgehog Signaling Pathway Studies
- Male Reproductive Health Studies
- Sperm and Testicular Function
- Monoclonal and Polyclonal Antibodies Research
- Prostate Cancer Treatment and Research
First Affiliated Hospital of GuangXi Medical University
2019-2025
Guangxi Medical University
2019-2025
Guangxi Center for Disease Prevention and Control
2021-2025
Jiangsu Academy of Agricultural Sciences
2024
Jiangxi Agricultural University
2024
Southwest Jiaotong University
2024
Chinese Institute for Brain Research
2019-2023
Beijing Normal University
2019-2023
Guangxi University
2023
Harbin University of Commerce
2023
Prostate cancer (PCa) is a high morbidity malignancy in males, and biochemical recurrence (BCR) may appear after the surgery. Our study designed to build up risk score model using circular RNA sequencing data for PCa. The dataset from GEO database, cohort of 144 patients Canada. We removed low abundance circRNAs (FPKM < 1) obtained 546 next step. BCR-related were selected by Logistic regression “survival” “survminer” R package. Least absolute shrinkage selector operation (LASSO) with...
Owing to incurable castration-resistant prostate cancer (CRPC) ultimately developing after treating with androgen deprivation therapy (ADT), it is vital devise new therapeutic strategies treat CRPC. Treatments that target programmed cell death protein 1 (PD-1) and ligand-1 (PD-L1) have been approved for human cancers clinical benefit. However, many patients, especially cancer, fail respond anti-PD-1/PD-L1 treatment, so an urgent need seek a support strategy improving the traditional...
Abstract A small population of cells with stem cell‐like properties in prostate cancer ( PC a), called (Pr CSC s) or stemness‐high cells, displays highly tumorigenic and metastatic features may be responsible for the therapy resistance. molecule, napabucasin BBI 608), recently have been identified suppression a variety cancers. However, effects on as well Pr s isolated from not yet defined. The effect cell proliferation, colony formation, migration vitro were measured by MTS , formation...
Purpose: We compared the safety and efficacy of diode laser enucleation prostate (DiLEP) with plasmakinetic resection (PKERP). Patients Methods: A total 80 patients bladder outflow obstruction from benign prostatic hyperplasia (BPH) were randomly assigned to either DiLEP or PKERP prospectively. All assessed preoperatively followed up at 3, 6, 12 months postoperatively. Baseline characteristics patients, perioperative data, postoperative outcomes compared. The operative data complications...
Previous studies have found that theta activities exhibit posterior lateralized modulation as well midfrontal event-related synchronization (ERS) during covert visual attention in adults. The present study investigated whether these modulations existed children and they were associated with attentional problems attention-deficit/hyperactivity disorder (ADHD). Electroencephalography signals recorded from typically developing (TD) ADHD (TD: n = 24; ADHD: 22) while performed a cued task....
In recent years, nanobodies have played an increasingly crucial role in virus neutralization, ELISA detection, and medical imaging. This study aimed to explore a universal expression strategy Pichia pastoris using three nanobodies, denoted Va, Vb, Vc, as model proteins. Initially, plasmids pLD-AOXα pLD-AOX were engineered minimize the risk of antibiotic resistance gene drift. Optimization promoters signal peptides resulted 1.38-fold 1.89-fold increase Va production. Further optimization...
Idiopathic CD4 lymphopenia (ICL) is a rare non-HIV-related syndrome, characterized by reduced T-cell count and predisposition to various opportunistic infections. However, Talaromyces marneffei (TM) infection has rarely been reported in ICL patients. Here, we report previously healthy 48-year-old male patient who presented with fever, headache, fatigue, vomiting, poor appetite. Mycological cultures from blood, bone marrow, liver spleen were positive for TM. The immunodeficiency evaluation...
The role of DNA methyltransferase 3B (DNMT3B) in tumorigenesis and development has been widely recognized; however, the mechanism underlying its action remains unclear. Considering function de novo methylation, we aimed to investigate whether DNMT3B plays via microRNA (miR)-34a promoter methylation bladder cancer. We found that expression was low 10 cancer tissues high 20 tissues. miR-34a higher with than DNMT3B. level negatively correlated ratio positively miR-34a. knockdown increased...
Attention-deficit/hyperactivity disorder (ADHD) is characterized by problems in directing and sustaining attention. Recent behavioral studies indicated that children with ADHD are more likely to fail show the orienting effect response human eye gaze. The present study aimed identify neurophysiological bases of attention deficits directed social gaze ADHD, focusing on relationship between alpha modulations symptoms. electroencephalography data were recorded from 8–13-year-old (typically...
The high variability and unpredictability of the plasma concentration voriconazole (VRC) pose a major challenge for clinical administration. aim this study was to develop population pharmacokinetics (PPK) model VRC identify factors influencing PPK in patients with talaromycosis. Medical records medication history talaromycosis who were treated as initial therapy collected. A total 233 blood samples from 69 included study. developed using nonlinear mixed-effects models (NONMEM). Monte Carlo...
This study aimed to identify the neurophysiologic bases of auditory attention deficits in children with attention-deficit/hyperactivity disorder (ADHD), focusing on electroencephalography component spatial selective [the N2 anterior contralateral (N2ac)]. EEG data were collected from 7- 11-year-old ADHD (n = 54) and age-, sex-, IQ-matched typically developing (TD) 61), while they performed an task. For behavior, showed a shorter reaction time (RT) but higher RT coefficient variability (RTCV)...
Immunoglobulin G (IgG) has been implicated in the progression of various cancers. This study explored role IgG proliferation, apoptosis, cell cycle and vitro invasive properties LNCaP prostate cancer cells. We used IGHG1 small interfering RNA to silence IgG1 expression The efficacy gene knockdown was confirmed using qPCR western blotting. colony formation, migration invasion abilities cells after transfection were assessed colony-forming, flow cytometry transwell assays. expressions PCNA...
Abstract Background Bladder cancer (BCa) is the most common urinary malignancy. The standard surgical treatment for patients with muscle‐invasive BCa cystectomy plus diversion. Ileal conduit (IC) or orthotopic neobladder (ON), which have different indications, are commonly performed diversions. Methods and materials We sampled 5480 from Surveillance, Epidemiology, End Results (SEER) database 2004 to 2015. Kaplan‐Meier method log‐rank test was used assess cancer‐specific survival (CSS)...
This study analyzed the in vitro drug sensitivity of Cryptococcus spp. from Guangxi, Southern China. One hundred three strains were recovered 86 patients; 14 HIV positive and 72 negative. Ninety-two identified as neoformans var. grubii , while 11 gattii (5 C. sensu stricto 6 deuterogattii ). The tested against commonly used antifungal drugs (fluconazole, amphotericin B, 5-fluorocytosine, itraconazole, voriconazole) to novel (posaconazole isavuconazole) using CLSI M27-A4 method. results...
Mutations of androgen receptor (AR) are the most frequent cause 46, XY disorders sex development and associated with a variety phenotypes, ranging from phenotypic women (complete insensitivity syndrome (CAIS)) to milder degrees undervirilization (partial form or PAIS) men only infertility (mild MAIS). From 2009 2012, two young Chinese female individuals CAIS families were referred our hospital due primary amenorrhea. Defects in testosterone (T) dihydrotestosterone (DHT) synthesis excluded....