A5102940536- Bladder and Urothelial Cancer Treatments
- Urinary Bladder and Prostate Research
- Prostate Cancer Diagnosis and Treatment
- RNA modifications and cancer
- Prostate Cancer Treatment and Research
- Renal and related cancers
- Renal cell carcinoma treatment
- Urological Disorders and Treatments
- MicroRNA in disease regulation
- Monoclonal and Polyclonal Antibodies Research
- Hormonal and reproductive studies
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Hybrid Renewable Energy Systems
- Gastrointestinal Tumor Research and Treatment
- Circular RNAs in diseases
- Cancer Immunotherapy and Biomarkers
- Urinary and Genital Oncology Studies
- Connexins and lens biology
- Cancer Risks and Factors
- Inflammatory Biomarkers in Disease Prognosis
- Cancer Mechanisms and Therapy
- Genetic and Kidney Cyst Diseases
- Protein purification and stability
- Sperm and Testicular Function
Southern Medical University
2012-2024
Zhujiang Hospital
2010-2024
Lund University
2013
Purpose: We compared the safety and efficacy of diode laser enucleation prostate (DiLEP) with plasmakinetic resection (PKERP). Patients Methods: A total 80 patients bladder outflow obstruction from benign prostatic hyperplasia (BPH) were randomly assigned to either DiLEP or PKERP prospectively. All assessed preoperatively followed up at 3, 6, 12 months postoperatively. Baseline characteristics patients, perioperative data, postoperative outcomes compared. The operative data complications...
The biological role of miR-26a involved in the carcinogenesis prostate cancer (PC) has been controversial. Besides, underlying mechanism by which plays a PC unclear. To investigate miR-26a-5p PC, was detected and statistically analyzed clinical tissues panel cell lines. Using bioinformatics analysis, we found that serpine1 messenger RNA (mRNA) binding protein 1 (SERBP1) potential downstream target miR-26a-5p. luciferase reporter western blot, identified negatively regulated SERBP1 on line...
Bufalin, one of the active ingredients Chinese drug Chan su, exhibits significant antitumor activity against various cancer types. However, role bufalin in renal cell carcinoma (RCC) remains unclear. In present study, it was demonstrated that inhibited proliferation, blocked cycle G2/M phase, and reduced metastasis human RCC ACHN cells via upregulation p21waf/cip1 E‑cadherin downregulation cyclin dependent kinase 1, B1, N‑cadherin, hypoxia‑inducible factor‑1α (HIF‑1α). Further mechanistic...
The role of DNA methyltransferase 3B (DNMT3B) in tumorigenesis and development has been widely recognized; however, the mechanism underlying its action remains unclear. Considering function de novo methylation, we aimed to investigate whether DNMT3B plays via microRNA (miR)-34a promoter methylation bladder cancer. We found that expression was low 10 cancer tissues high 20 tissues. miR-34a higher with than DNMT3B. level negatively correlated ratio positively miR-34a. knockdown increased...
According to the EAU Guidelines, transurethral resection of prostate (TURP) has so far still been considered as gold standard for surgical treatment patients with obstructing clinical benign hyperplasia (BPH). However, its relatively high rate complications and postoperative recurrence necessitates further modification innovation on surgery technique. We reported patient outcomes our technique.We retrospectively analyzed 52 BPH who underwent bipolar enucleation (B-TUERP) between March 2015...
Immunoglobulin G (IgG) has been implicated in the progression of various cancers. This study explored role IgG proliferation, apoptosis, cell cycle and vitro invasive properties LNCaP prostate cancer cells. We used IGHG1 small interfering RNA to silence IgG1 expression The efficacy gene knockdown was confirmed using qPCR western blotting. colony formation, migration invasion abilities cells after transfection were assessed colony-forming, flow cytometry transwell assays. expressions PCNA...
circCPA4 has been defined to be an oncogenic gene. This study examined whether regulates Prostate Cancer (PC) development and revealed its molecular mechanism. PC tissues cell lines were collected, in which circCPA4/miR-491-5p/SHOC2 levels evaluated by RT-qPCR immunoblot. Colony formation assay EdU assessed proliferation, flow cytometry measured apoptosis, Transwell invasion migration. Ki-67, cleaved caspase-3, E-cadherin, N-cadherin Based on the luciferase reporter RIP authors investigated...
Rationale: Renal cysts in patients with autosomal dominant polycystic kidney disease (ADPKD) can originate from any nephron segments, including proximal tubules (PT), the loop of Henle (LOH), distal (DT), and collecting ducts (CD). Previous studies mostly used limited cell markers failed to identify cells negative for these markers. Therefore, composition origin ADPKD cyst are still unclear, mechanisms cystogenesis different origins await further exploration. Methods: We performed...
Taxane based chemotherapy is the standard of care treatment in castration resistant prostate cancer (CRPC). There convincing evidence that taxane therapy affects androgen receptor (AR) but exact mechanisms have to be further elucidated. Our studies identified c-jun as a crucial key player which interacts with AR and thus determines outcome given. Docetaxel (Doc) paclitaxel (Pac) agents showed different effects on LNCaP LNb4 evidenced by alteration protein mRNA levels c-jun, PSA....
You have accessJournal of UrologyVideo Session, Tuesday, May 23, 2006, 1:00 - 3:00 pm1 Apr 2006V1403: Real Endo-Enucleation Prostate for Treatment Benign Prostatic Hyperplasia Chunxiao Liu, Abai Xu, Shaobo Zheng, Hulin Li, Yawen Binshen Chen, and Ping Fang LiuChunxiao Liu More articles by this author , XuAbai Xu ZhengShaobo Zheng LiHulin Li XuYawen ChenBinshen Chen FangPing View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)33970-3AboutPDF ToolsAdd to favoritesDownload...
Prostate cancer stem cells (PrCSCs) are responsible for the development of castration-resistant disease and associated with poor outcomes; however, origin PrCSCs is still not known due to lack a suitable model. In current study, human prostate cell line 22RV1 was used generate induced pluripotent (iPSCs) via exogenous expression four classic transcription factors (OCT-4, SOX2, KLF4, C-MYC). The iPSCs were analyzed by phase contrast microscopy, real-time polymerase chain reaction,...
To investigate the expression of DNMT3b in human bladder cancer tissues and its correlation with postoperative survival patients cancer.Thirty-eight pairs surgically resected adjacent were detected by immunohistochemistry for expression, correlations level analyzed patients'age, gender, pathological grade, tumor size, T stage, lymph node metastasis TNM stages. Kaplan-Meier analysis was performed to assess effect on outcomes patients.High protein 63.16% 13.16% (P < 0.05). The associated grade...
e16602 Background: Cisplatin-based neoadjuvant chemotherapy is the standard of care in MIBC with improved pathologic response (PaR) and overall survival (OS) compared to radical cystectomy (RC) alone. The efficacy PD-1 inhibitor combination as a new treatment option for still needs further confirmation. This study evaluated safety toripalimab (an anti-PD-1 monoclonal antibody) combined gemcitabine-cisplatin (GC) therapy patients MIBC. Methods: Eligible pts (cT2-T4a, N≤1, M0) who were...
Objective To discuss the treatment efficacy of intrafascial endoscopic extraperitoneal radical prostatectomy(EERPE)in prostate cancer patients. Methods The operation was performed in 23 patients.The mean age 65 years old.Preoperative prostate-specific antigen(PSA)level 4.5-8.6(6.2±2.1)ng/ml,and patients distribution as Gleason Score 5 3 cases,Gleason 6 11 cases and 7 9 cases.Eighteen had preoperative potency.The technique to keep endopelvic fascia intact.The prostatic incised anterior...
You have accessJournal of Urology1 Apr 2008TRANSURETHRAL ENUCLEATIVE RESECTION OF PROSTATE WITHOUT LASER Liu Chunxiao, Xu Abai, Zheng Shaobo, Li Hulin, Yawen, Chen Binshen, Fang Ping, and Bian Jun ChunxiaoLiu Chunxiao More articles by this author , AbaiXu Abai ShaoboZheng Shaobo HulinLi Hulin YawenXu Yawen BinshenChen Binshen PingFang Ping JunBian View All Author Informationhttps://doi.org/10.1016/S0022-5347(08)61959-XAboutPDF ToolsAdd to favoritesDownload CitationsTrack...