A5006455169- Renal Transplantation Outcomes and Treatments
- Cancer-related gene regulation
- Cytomegalovirus and herpesvirus research
- Cancer-related molecular mechanisms research
- Polyomavirus and related diseases
- Transplantation: Methods and Outcomes
- Organ Transplantation Techniques and Outcomes
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Genetic and Kidney Cyst Diseases
- RNA modifications and cancer
- Viral-associated cancers and disorders
- Renal and related cancers
- Organ and Tissue Transplantation Research
- Thyroid Cancer Diagnosis and Treatment
- Blood groups and transfusion
- Thyroid and Parathyroid Surgery
- Parvovirus B19 Infection Studies
- Cancer Mechanisms and Therapy
- Biochemical and Molecular Research
- Head and Neck Anomalies
- Renal and Vascular Pathologies
- Antifungal resistance and susceptibility
- Pediatric Urology and Nephrology Studies
- Fungal Infections and Studies
Nanfang Hospital
2016-2025
Southern Medical University
2015-2024
Shanghai First People's Hospital
2019-2024
Sanda University
2024
Sun Yat-sen University Cancer Center
2015-2023
State Key Laboratory of Oncology in South China
2015-2023
Sun Yat-sen University
2013-2023
Weatherford College
2021
Nanjing Forestry University
2017
The First Affiliated Hospital, Sun Yat-sen University
2013-2016
Transplant recipients are at increased risk of malignancy; however, the influence transplantation on cancer outcomes has not been rigorously defined. The purpose this study was to examine individual cancers.De novo nonsmall cell lung cancer, colon breast prostate bladder renal (RCC), and malignant melanoma data in 635 adult (>18 years age) transplant (from Israel Penn International Tumor Registry) were compared with from 1,282,984 adults general population Surveillance, Epidemiology, End...
The functional status of mitochondria and the endoplasmic reticulum are central to renal ischemia/reperfusion injury (IRI). X-box binding protein 1 (XBP1) is an important transcription factor in stress. NLR family pyrin domain containing-3 (NLRP3) inflammatory bodies closely related IRI. In vivo vitro, we examined molecular mechanisms functions XBP1-NLRP3 signaling IRI, which influences ER-mitochondrial crosstalk. this study, mice were subjected 45 min unilateral warm ischemia, other kidney...
Abstract Background The development of chemoresistance and metastasis are the leading causes death for gastric cancer (GC) patients, however, molecular mechanisms involved remain unclear. Dysregulation miRNAs is associated with a variety disease, including GC. Recently, microarray profiling analysis revealed that miR-939 was dysregulated in human GC samples, but role has not been intensively investigated. Methods In present study, we firstly examined expression pattern two independent...
We previously reported the oncogenic role of paired-like homeodomain 2 (PITX2) in esophageal squamous cell carcinoma (ESCC). In this study, we aimed to identify miRNA regulators PITX2 and mechanism underlying pathogenesis ESCC.Using profiling bioinformatics analyses, identified miR-644a as a negative mediator ESCC. A series vivo vitro assays were performed confirm effect on PITX2-mediated ESCC malignancy.ESCC cells tissues expressed less than normal epithelial controls. patient samples,...
Abstract Ischemia-reperfusion (IR) injury to the renal epithelia is associated with endoplasmic reticulum stress (ERS) and mitochondria dysfunction, which lead oxidative stress-induced acute kidney (AKI). X-box binding protein 1 (XBP1), an ERS response protein, could play a prominent role in IR-induced AKI. In this study, we revealed that XBP1 its downstream target HRD1 participated crosstalk between mitochondrial dysfunction via regulation of NRF2/HO-1-mediated reactive (ROS) signaling....
Plenty of studies have established that dysregulation autophagy plays an essential role in cancer progression. The autophagy-related proteins been reported to be closely associated with human patients' prognosis. We explored the expression dynamics and prognostic value protein ULK1 by immunochemistry (IHC) method two independent cohorts nasopharygeal carcinoma (NPC) cases. X-tile program was applied determine optimal cut-off training cohort. This derived cutoff then subjected analysis...
The classical lytic infection theory along with large T antigen-mediated oncogenesis cannot explain the BK polyomavirus (BKPyV)-associated tumor secondary to BKPyV-associated nephropathy (BKVAN), viremia/DNAemia, and viruria after renal transplantation. This study performed virome capture sequencing pathological examination on regularly collected urine sediment peripheral blood samples, BKVAN biopsy tissues of 20 patients diseases different stages. In early noncancerous stages,...
// Jia-Xing Zhang 1, 2, * , Miao Yun 3, Yi Xu Jie-Wei Chen 4 Hui-Wen Weng 1 Zou-San Zheng Cui Dan Xie 2 Sheng Ye Department of Oncology, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, PR China University Cancer Center, State Key Laboratory Oncology in South China, Collaborative Innovation Center for Medicine, 3 Ultrasound, Pathology, These authors contributed equally to this work Correspondence to: Sheng, e-mail: yes20111212@163.com Xie, xiedan@sysucc.org.cn Keywords:...
Abstract Inosine monophosphate dehydrogenase type II (IMPDH2) has been shown to play critical roles in the development and progression of several human cancers. However, little is known about IMPDH2 expression its clinical significance nasopharyngeal carcinoma (NPC). Western blotting, qRT-PCR immunohistochemistry were employed evaluate NPC cell lines tissues. In our study, elevated was observed at both protein mRNA levels than NPEC2 Bmi-1. markedly higher tissues adjacent non-tumorous...
Retaining the native bilateral kidneys after transplantation is a common treatment for patients with end-stage autosomal dominant polycystic kidney disease. However, this strategy poses risks of potential complications from infection. The efficiency antibiotic therapy and optimal time nephrectomy in managing these infections remain uncertain. We report case transplant recipient retained who experienced recurrent cyst bloodstream infections, accompanied by antibiotic-driven pathogen...
Abstract Solute carrier family 34 member 2 (SLC34A2), a pH-sensitive sodium-dependent phosphate transporter, is associated with several human cancers. In this study, we investigate the clinical significance of SLC34A2 and its function in bladder cancer (BC). The expression dynamics were examined two independent cohorts BC samples by quantitative PCR, western blotting immunohistochemical staining. training cohort (156 cases), applied X-tile program software to assess optimal cutoff points for...
Abnormal expression of O-Linked β-N-acetylglucosamine (O-GlcNAc) and β-catenin is a general feature cancer contributes to transformed phenotypes. In this study, we identified the interaction between O-GlcNAc β-catenin, explored their effects on progression liver cancer. Our results demonstrated that upregulation was induced by high glucose, whereas application PuGNAc GlcNAc increased protein levels, as well protein's stability nuclear accumulation in cell lines HEP-G2 HuH-7. addition,...
Talaromyces marneffei (TSM) is a temperature-dependent dimorphic fungus endemic to Southeast Asia and southern China. As the number of people at risk TSM infection continues increase, clinical manifestations are becoming increasingly complex, posing challenges for management. In this study, we analyzed medical records 99 patients (71 human immunodeficiency virus [HIV]-positive 28 HIV-negative) diagnosed with from January 1, 2017, December 31, 2022, in China compared HIV-positive HIV-negative...
Objectives This study assessed the efficacy and safety of transvaginal ultrasound (US)‐guided core needle biopsy (CNB) for obtaining adequate pelvic mass samples histologic analysis evaluated factors that may affect success. Methods Two hundred cases underwent US‐guided CNBs primary inoperable tumors, suspicion metastases to ovaries or peritoneum, recurrence, other solid lesions in pelvis. Biopsy were obtained from cavity (67.0%), vaginal cuff wall (17.5%), peritoneal cake (15.5%). The...
WD repeat-containing protein 5 (WDR5) is essential for assembling the VISA-associated complex to induce a type I interferon antiviral response Sendai virus infection. However, roles of WDR5 in DNA infections are not well described. Here, we report that human cytomegalovirus exploits facilitate capsid nuclear egress. Overexpression fibroblasts slightly enhanced infectious yield. knockdown dramatically reduced titers with only small decrease viral genome replication or gene expression. Further...
Abstract Guanine nucleotide binding protein alpha 13 (GNA13) has been found to play critical roles in the development of several human cancers. However, little is known about GNA13 expression and its clinical significance hepatocellular carcinoma (HCC). In our study, was reported be significantly up-regulated HCC tissues, this correlated with clinicopathological parameters, including tumor multiplicity (P = 0.004), TNM stage 0.002), BCLC 0.010). Further Cox regression analysis suggested that...
In this study, the effects of yeast strains on anthocyanin, color, and antioxidant activity mulberry wines were investigated. Principal component analysis (PCA) used to evaluate differences among five wines. Results showed that have a significant effect The total phenol content in 145.42–197.65 mg gallic acid equivalents/100 mL. Cyanidin-3-O-glucoside (C3G) cyanidin-3-O-rutinoside (C3R) two major anthocyanins wine. C3G contents ranged from 3.56 7.69 mg/100 mL, while C3R 4.28 8.38 Total...
Abstract Background Metastasis remains the main cause of cancer-related death for gastric cancer (GC) patients, but mechanisms are poorly understood. Using The Cancer Genome Atlas (TCGA) data base and bioinformatics analyses, we identified C12orf59 might act as a potential oncogenic protein in GC. Methods We investigate expression pattern clinical significance two independent cohorts GC samples. In training cohort, used X-tile program software to generate optimal cutoff value order classify...
Low-level BK polyomavirus (BKPyV) shedding is seen in at least 10% of seropositive immunocompetent adults. Moreover, BKPyV infection highly prevalent amongst immunocompromised populations, yet little known on its relationship with malignancy. We studied a female patient BKPyV-associated and donor-derived de novo high-grade sarcomatoid urothelial carcinoma developed 8 years after kidney transplantation from male donor. Through whole-genome sequencing, we discovered integration genotype IV...