A5075630598- CAR-T cell therapy research
- Acute Myeloid Leukemia Research
- Advancements in Semiconductor Devices and Circuit Design
- RNA modifications and cancer
- Acute Lymphoblastic Leukemia research
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Hematopoietic Stem Cell Transplantation
- Chronic Myeloid Leukemia Treatments
- Cancer, Lipids, and Metabolism
- Immune cells in cancer
- Protein Degradation and Inhibitors
- Cancer-related gene regulation
- Mesenchymal stem cell research
- Nanoplatforms for cancer theranostics
- Integrated Circuits and Semiconductor Failure Analysis
- RNA Interference and Gene Delivery
- Endoplasmic Reticulum Stress and Disease
- Cancer, Hypoxia, and Metabolism
- Peptidase Inhibition and Analysis
- Organ Transplantation Techniques and Outcomes
- Autophagy in Disease and Therapy
- Heme Oxygenase-1 and Carbon Monoxide
- Circular RNAs in diseases
- Educational Technology and Assessment
Baoding People's Hospital
2025
Tongji Hospital
2021-2024
Wuhan Union Hospital
2023-2024
Southern Medical University
2023-2024
Huazhong University of Science and Technology
2019-2024
Dongguan People’s Hospital
2024
Army Medical University
2018-2023
Southwest Hospital
2010-2023
Union Hospital
2019-2023
Union Hospital
2022-2023
The immunotherapeutic effect elicited by photodynamic therapy (PDT) is attenuated tumor defense mechanisms associated with glutamine metabolism, including the metabolic regulation of redox homeostasis and limitation immunosuppressive microenvironment (ITM). Herein, a carrier-free nanobooster C9SN dual synergistic effects was constructed self-assembly glutaminase (GLS) inhibitor compound 968 (C968) photosensitizer Chlorin e6. C968-mediated GSH deprivation through inhibiting metabolism...
The functional status of mitochondria and the endoplasmic reticulum are central to renal ischemia/reperfusion injury (IRI). X-box binding protein 1 (XBP1) is an important transcription factor in stress. NLR family pyrin domain containing-3 (NLRP3) inflammatory bodies closely related IRI. In vivo vitro, we examined molecular mechanisms functions XBP1-NLRP3 signaling IRI, which influences ER-mitochondrial crosstalk. this study, mice were subjected 45 min unilateral warm ischemia, other kidney...
Abnormal tumor metabolism creates a complex immune microenvironment that plays dominant role in the metastasis of triple-negative breast cancer (TNBC). TNBC is insensitive to checkpoint blockade (ICB) therapy because insufficient cytotoxic T lymphocyte (CTL) infiltration and hyper-lactic acid-suppressive caused by abnormal glycolysis. Herein, we propose an amplified strategy based on lactic acid regulation reprogram immunosuppressive (ITM) combine it with ICB achieve enhanced antitumor...
Abstract T cells modified with anti‐ CD 19 chimeric antigen receptor ( CAR ) containing either 28 or 4‐1 BB (also termed TNFRSF 9, 137) costimulatory signalling have shown great potential in the treatment of acute lymphoblastic leukaemia ALL ). However, difference between and ‐T has not been well elucidated clinical trials. In this study, we treated 10 relapsed refractory patients second generation ‐T. The first 5 were 28‐ other All response‐evaluable. Three achieved complete remission 1...
Inherent or acquired resistance to chemotherapeutic drugs is still an obstacle for the treatment of multiple myeloma (MM). MicroRNA dysregulation related development chemoresistance in cancers. However, its role MM largely unknown. Here we demonstrated that miR-221/222 were upregulated plasma cells from patients with MM, especially those relapsed refractory disease. Moreover, expression levels inversely correlated dexamethasone (Dex) sensitivity human cell lines. Importantly, found Dex...
Abstract Purpose: Immunogenicity derived from the murine scFv, a major molecular compomemt of chimeric antigen receptors (CARs), may limit persistence CAR T cells, resulting in tumor relapse patients complete remission (CR). In this study, we developed humanized anti-CD19 scFv CAR-T (hCAR-T) to treat with relapsed/refractory acute lymphoblastic leukemia (r/r ALL). Patients and Methods: one-arm, open-labeled infused cells modified hCAR r/r ALL. were evaluated long-term follow-up for response...
N6-methyladenosine (m6A), as the most pervasive internal modification of eukaryotic mRNA, plays a crucial role in various cancers, but its multiple myeloma (MM) pathogenesis has not yet been investigated. In this study, we revealed significantly decreased m6A methylation plasma cells (PCs) from MM patients and showed that abnormal level resulted mainly upregulation demethylase fat mass obesity-associated protein (FTO). Gain- loss-of-function studies demonstrated FTO tumor-promoting...
Abstract Ischemia-reperfusion (IR) injury to the renal epithelia is associated with endoplasmic reticulum stress (ERS) and mitochondria dysfunction, which lead oxidative stress-induced acute kidney (AKI). X-box binding protein 1 (XBP1), an ERS response protein, could play a prominent role in IR-induced AKI. In this study, we revealed that XBP1 its downstream target HRD1 participated crosstalk between mitochondrial dysfunction via regulation of NRF2/HO-1-mediated reactive (ROS) signaling....
Abstract Overactive fatty acid metabolism is usually found in hematological malignancies including multiple myeloma (MM), but the underlying mechanisms remain unclear. Here, we reveal that acyl-CoA synthetase long-chain family member 4 (ACSL4) abnormally overexpressed MM cell lines and patients compared to healthy donors. Knockdown of ACSL4 inhibited proliferation reduced levels possibly by regulating lipid genes c-Myc sterol regulatory element binding proteins (SREBPs). As a propellent...
Abstract Background Leukemia stem cells (LSCs) are responsible for the initiation, progression, and relapse of acute myeloid leukemia (AML). Therefore, a therapeutic strategy targeting LSCs is potential approach to eradicate AML. In this study, we aimed identify LSC-specific surface markers uncover underlying mechanism AML LSCs. Methods Microarray gene expression data were used investigate candidate AML-LSC-specific markers. CD9 in cell lines, patients with AML, normal donors was evaluated...
Abstract MALAT1 is one of the most hopeful members implicated in angiogenesis a variety non-malignant diseases. In multiple myeloma (MM), recognized as highly expressed long non-coding RNA. However, functional roles and responsible mechanisms have not yet been explored. Herein, we discovered novel regulatory network dependent on relation to MM tumorigenesis angiogenesis. We observed that was upregulated significantly associated with poor overall survival. knockdown suppressed cell...
Several particular kinds of typical morphology characteristics leukemic blasts associated with the specific subtypes leukemia have been reported. However, B acute lymphoblastic leukemia/lymphoma (B-ALL/LBL) has rarely The purpose this study was to investigate correlation TCF3::PBX1 fusion multiple clefts nuclei in patients B-ALL/LBL. We retrospectively reviewed peripheral blood (PB) and bone marrow (BM) smears 145 prepared at time initial diagnosis B-ALL/LBL based on results testing for...
Leptomeningeal carcinomatosis (LC) is a severe complication in the advanced stage of lung adenocarcinoma, with an extremely poor prognosis. Currently, diagnosis LC poses challenges. Serum exosomal miRNAs (microRNAs) have been demonstrated to possess potential as viable biomarkers. However, their value remains unclear. In this study, serum samples were collected from adenocarcinoma patients LC. The control groups consisted early-stage and advanced-stage without exosomes isolated for high -...
Background: The detection of mutations from circulating tumor DNA (ctDNA) represents a promising enrichment technique. In this retrospective study, the significance ctDNA and imaging in Langerhans cell histiocytosis (LCH) monitoring was first examined, broader role LCH additionally explored. Methods: First, data visualization survival analysis models were used to generalize concordance between cfBRAFV600E molecular response radiographic on clinical outcomes. Next, observed dynamic...
While many factors that are associated with increased mortality in septic shock patients have been identified, the effects of serum osmolarity on outcomes ICU not yet studied. The present study was designed to examine association 28-day shock. Adult diagnosed from MIMIC-IV database were selected this study. calculated synchronously according concentrations Na+, K+, glucose, and urea nitrogen. In study, a significant difference observed between hypo-osmolarity, hyper-osmolarity, normal...
Abstract Multiple myeloma (MM) is a clonal plasma cell malignancy that characterized by genetic heterogeneity. The cytogenetic abnormality t(4;14) strongly predicts poor outcome in patients with MM, even the era of novel drugs. Ferroptosis new approach to antitumor therapy, but relationship between ferroptosis and MM abnormalities remains largely unclear. In this study, we show t(4;14)-positive not t(4;14)-negative cells are susceptible class II inducers (FINs) preclinical setting, which...
Organ transplantation is an important method to save the lives of patients suffering from organ failure. However, low rate donation a common problem worldwide. Many potential donors in intensive care unit (ICU) are not properly identified, which one reason for rate. ICU nurses play key role but may be uncertain regarding some issues. In this study, analysis reasons why western China reluctant encourage and their families donate organs performed, providing reference promoting nurse...
Feature selection is to obtain effective features from data, also known as feature engineering. Traditional and predictive model learning are separated, there a problem of inconsistency criteria. This paper presents an end-to-end diagnosis method that organically unifies expression machine prediction into one model. The algorithm first combines the calculate mean impact value (MIVs) realizes primary for by selecting with larger MIV. In order take account performance itself, within-class...
Abstract Background: Leukemia stem cells (LSCs) are responsible for the initiation, progression and relapse of acute myeloid leukemia (AML). Therefore, a therapeutic strategy targeting LSCs is potential approach to eradicate AML. In this study, we aimed identify LSC-specific surface markers uncover underlying mechanism AML LSCs. Methods: Microarray gene expression data were used investigate candidate AML-LSC-specific markers. CD9 in cell lines, patients with normal donors was evaluated by...