A5101602004- Nanoplatforms for cancer theranostics
- Single-cell and spatial transcriptomics
- interferon and immune responses
- Ferroptosis and cancer prognosis
- Immune cells in cancer
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Air Quality and Health Impacts
- Photodynamic Therapy Research Studies
- Extracellular vesicles in disease
- Cancer, Hypoxia, and Metabolism
- Sperm and Testicular Function
- Ocular Diseases and Behçet’s Syndrome
- Immune Cell Function and Interaction
- Nanoparticle-Based Drug Delivery
- Inflammatory Bowel Disease
- Reproductive Biology and Fertility
- Garlic and Onion Studies
- Bioactive natural compounds
- Chemotherapy-induced organ toxicity mitigation
- Hippo pathway signaling and YAP/TAZ
- Genetic factors in colorectal cancer
- Selenium in Biological Systems
- Calcium Carbonate Crystallization and Inhibition
Shanghai East Hospital
2025
Guangdong Academy of Medical Sciences
2024
Southern Medical University
2016-2024
Guangdong Provincial People's Hospital
2024
Third Affiliated Hospital of Southern Medical University
2021-2024
Hunan Provincial Maternal and Child Health Hospital
2024
Xiamen University of Technology
2024
Southwest Medical University
2024
Capital Medical University
2016-2024
Beijing Chaoyang Emergency Medical Center
2021-2024
The immunotherapeutic effect elicited by photodynamic therapy (PDT) is attenuated tumor defense mechanisms associated with glutamine metabolism, including the metabolic regulation of redox homeostasis and limitation immunosuppressive microenvironment (ITM). Herein, a carrier-free nanobooster C9SN dual synergistic effects was constructed self-assembly glutaminase (GLS) inhibitor compound 968 (C968) photosensitizer Chlorin e6. C968-mediated GSH deprivation through inhibiting metabolism...
The endothelial cell exists in the whole body by lining inner surface of vasculature and plays an important role normal physiology disease progressions. Each organ should have a heterogeneous population cells, but these heterogeneities not been systematically analyzed at single level. Tabular Muris project profiled mouse cells from 20 organs, which includes 10 organs. Unsupervised analysis found they were mainly grouped each organ-specific further partially correlated germ layers....
In the process of cryopreservation dairy goat semen, it will face many threats such as oxidative damage, which affect motility and plasma membrane function sperm. As an endogenous antioxidant in animals, glutathione (GSH) can significantly improve quality thawed sperm when added to frozen diluent semen pigs cattle. this study, different concentration gradients GSH [0 mmol/L (control), 1, 2, 3, 4 mmol/L] were Guanzhong semen. By detecting parameters, acrosome intact rate after thawing, effect...
Background & AimsGenome-wide association studies (GWAS) and transcriptome analyses have been performed to better understand the pathogenesis of ulcerative colitis (UC). However, current mainly focus on European ancestry, highlighting a great need identify key genes, pathways cell types in colonic mucosal cells adult UC patients from other ancestries. Here we aimed genes UC.MethodsWe Single-cell RNA sequencing (scRNA-seq) analysis 12 colon biopsies healthy controls Chinese Han...
Abstract The diagnosis and treatment of ovarian cancer (OC) are still a grand challenge, more than 70% patients diagnosed at an advanced stage with dismal prognosis. Magnetic resonance imaging (MRI) has shown superior results to other examinations in preoperative assessment, while cisplatin‐based chemotherapy is the first‐line for OC. However, few previous studies have brought together two rapidly expanding fields. Here technique presented using cisplatin prodrug (Pt‐COOH), Fe 3+ , natural...
Abstract Ovarian cancer is a highly fatal gynecologic malignancy worldwide. Chemotherapy remains the primary modality both for and maintenance treatments of ovarian cancer. However, progress in developing chemotherapeutic agents has been slow past 20 years. Thus, new effective drugs are urgently needed treatment. A reduction-responsive synergetic delivery strategy (PSSP@ART-ISMN) with co-delivery artesunate isosorbide 5-mononitrate was investigated this research study. PSSP@ART-ISMN had...
Ovarian cancer (OC) is one of the most common and recurring malignancies in gynecology. Patients with relapsed OC always develop "cascade drug resistance" (CDR) under repeated chemotherapy, leading to subsequent failure chemotherapy. To overcome this challenge, amphiphiles (P1) carrying a nitric oxide (NO) donor (Isosorbide 5-mononitrate, ISMN) high-density disulfide are synthesized for encapsulating mitochondria-targeted tetravalent platinum prodrug (TPt) construct nanocomposite (INP@TPt)....
Abstract Mucus injury associated with goblet cell (GC) depletion constitutes an early event in inflammatory bowel disease (IBD). Using single-cell sequencing to detect critical events mucus dysfunction, we discover that the Kazal-type serine protease inhibitor SPINK4 is dynamically regulated colitic intestine parallel activities. Under chemically induced conditions, grim status Spink4 -conditional knockout mice successfully rescued by recombinant murine SPINK4. Notably, its therapeutic...
Abstract Allelic loss on chromosome 13 occurs frequently in esophageal squamous cell carcinoma. However, studies of the two known tumor suppressor genes located 13q, RB1 and BRCA2 , have shown few mutations, suggesting that other are likely to be involved development this type. To identify a minimal deletion interval, we first analyzed 42 microsatellite markers spanning bands 13q11‐q13 56 carcinoma patients, including 34 with family history upper gastrointestinal cancer 22 without cancer....
PLOD2 is overexpressed in diverse tumors and plays a vital role tumorigenesis. However, the prognostic value of cervical cancer (CESC) remains unclear.PLOD2 expression CESC patients' survival data were collected from Oncomine, GEPIA, UALCAN, Kaplan-Meier Plotter databases; immunohistochemistry (IHC) was used to validate CESC; Gene Set Enrichment Analysis performed using STRING DAVID correlations between immune infiltrates investigated TIMER TISIDB databases.We found that level increased...
Long-term air pollution exposure and inflammation are considered to be associated with cognitive decline. However, whether related decline is dependent on remains uncertain. The present study collected data from China Health Retirement Longitudinal Study (CHARLS) at baseline in 2011, a follow up period 2015. Concentration of pollutants (particles diameters ≤ 1.0 μm [PM1], 2.5 [PM2.5], 10 [PM10], nitrogen dioxide [NO2] ozone [O3]) were obtained High Air Pollutants (CHAP) dataset....
Sorafenib is a first-line drug for liver cancer treatment, but its clinical efficacy still limited by drawbacks such as tolerance, toxic effects, and low bioavailability. Therefore, it urgent to find efficient ways synergize sorafenib with other agents increase bioavailability in order enhance efficacy. Herein, we report the successful development of carrier-free nanoplatform an artesunate prodrug potentiate against hepatocellular carcinoma. The was synthesized conjugating linoleic acid...
The pharmacokinetics and relative bioavailability/bioequivalence of 2 formulations indapamide were assessed in this paper. study was conducted 20 healthy Chinese male volunteers according to an open, randomized, single-blind, 2-way crossover design with a wash-out phase 7 days. Blood samples for pharmacokinetic profiling taken up 84 h post-dose, concentrations plasma determined by validated liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS) method. Based on the...
Background: Finding molecular markers linked to quantitative trait loci is the first step in markerassisted selection (MAS).Microsatellites are excellent because of their large numbers, even distribution genome, and high polymorphism.In this study, polymerisation effect four microsatellites (OarAE101, BM1329, BM143, LSCV043) on litter size was analysed using microsatellite pedigrees. Results:The results indicate that significantly affected size.E5E10F2F6G1G5H6H11 E3E8F5F7G1G5H3H9 had highest...
<title>Abstract</title> Background Long-term air pollution exposure and inflammation are considered to be associated with cognitive decline. However, whether related decline is dependent on remains uncertain. Material Methods The present study collected data from China Health Retirement Longitudinal Study (CHARLS) at baseline in 2011, a follow up period 2015. Concentration of pollutants (particles diameters ≤ 1.0µm [PM<sub>1</sub>], 2.5µm [PM<sub>2.5</sub>], 10µm [PM<sub>10</sub>], nitrogen...
In this paper, a joint algorithm based on variational mode decomposition (VMD) and White Shark Optimizer (WSO) is proposed for non-contact vital signs detection. First, the phase information obtained from radar echo signal. Then, respiratory heartbeat components are separated using bandpass filter. The component processed by second-order differencing. At same time, heart rate estimated decomposing WSO-VMD. WSO makes VMD parameters adaptive, filters out breathing harmonics interfering with...