A5101603422- Esophageal Cancer Research and Treatment
- RNA modifications and cancer
- Cancer-related gene regulation
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Chronic Lymphocytic Leukemia Research
- Epigenetics and DNA Methylation
- Lymphoma Diagnosis and Treatment
- Galectins and Cancer Biology
- Cancer-related molecular mechanisms research
- Natural Language Processing Techniques
- Topic Modeling
- Corneal surgery and disorders
- MicroRNA in disease regulation
- Lung Cancer Treatments and Mutations
- Viral Infectious Diseases and Gene Expression in Insects
- Neurobiology and Insect Physiology Research
- Corneal Surgery and Treatments
- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Glaucoma and retinal disorders
- Ocular Surface and Contact Lens
- Vasculitis and related conditions
- Molecular Biology Techniques and Applications
- Ferroptosis and cancer prognosis
University of Cologne
2024-2025
Nantong University
2011-2025
University of Cambridge
2005-2025
Shenyang Agricultural University
2021-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2011-2025
Howard Hughes Medical Institute
2024-2025
Janelia Research Campus
2024-2025
Soochow University
2023-2025
National University of Defense Technology
2025
Henan Institute of Science and Technology
2022-2025
Left atrial fibrosis is prominent in patients with fibrillation (AF). Extensive tissue identified by delayed enhancement magnetic resonance imaging (MRI) has been associated poor outcomes of AF catheter ablation.To characterize the feasibility estimation MRI and its association subsequent ablation outcome.Multicenter, prospective, observational cohort study diagnosed paroxysmal persistent (undergoing their first ablation) conducted between August 2010 2011 at 15 centers United States,...
Aberrant activation of Bruton's tyrosine kinase (BTK) plays an important role in pathogenesis B-cell lymphomas, suggesting that inhibition BTK is useful the treatment hematological malignancies. The discovery a more selective on-target covalent inhibitor high value. Herein, we disclose and preclinical characterization potent, selective, irreversible as our clinical candidate by using vitro potency, selectivity, pharmacokinetics (PK), vivo pharmacodynamic for prioritizing compounds. Compound...
Abstract Purpose: Esophageal squamous cell carcinoma (ESCC) is an aggressive tumor with poor prognosis. Understanding molecular changes in ESCC will enable identification of subtypes and provide potential targets for early detection therapy. Experimental Design: We followed up a previous array study additional discovery confirmatory studies new cases by using alternative methods. profiled global gene expression confirmation, validated selected dysregulated genes RNA protein studies. Results:...
Background: Since the first case of a novel coronavirus (COVID-19) infection pneumonia was detected in Wuhan, China, series confirmed cases COVID-19 were found Beijing. We analyzed data 262 to determine clinical and epidemiological characteristics Methods: collected patients who transferred by Beijing Emergency Medical Sevice designated hospitals. The information on demographic, epidemiological, clinical, laboratory test for virus, diagnostic classification, cluster outcome obtained....
Corn is one of the main food crops in China, and its area ranks top three world. However, corn leaf disease has seriously affected yield quality corn. To quickly accurately identify diseases, taking timely effective treatment to reduce loss yield. We proposed identifying diseases using Mobilenetv3 (CD-Mobilenetv3) model. Based on model, we replaced model’s cross-entropy function with a bias improve accuracy. Replaced squeeze excitation (SE) module efficient channel attention (ECA)...
Techniques that enable precise manipulations of subsets neurons in the fly central nervous system (CNS) have greatly facilitated our understanding neural basis behavior. Split-GAL4 driver lines allow specific targeting cell types Drosophila melanogaster and other species. We describe here a collection 3060 range adult CNS 1373 characterized third-instar larvae. These tools functional, transcriptomic, proteomic studies based on anatomical targeting. NeuronBridge search relate light microscopy...
Genomic instability plays an important role in human cancers. We previously characterized genomic esophageal squamous cell carcinomas (ESCC) terms of loss heterozygosity (LOH) and copy number (CN) changes tumors using the Affymetrix GeneChip Human Mapping 500K array 30 cases from a high-risk region China. In current study we focused on neutral (CN = 2) LOH (CNNLOH) its relation to gene expression ESCC.Overall found that 70% all observed was CNNLOH. Ninety percent ESCCs showed CNNLOH (median...
Details of the mechanisms that determine shape and positioning organs in body cavity remain largely obscure. We show stereotypic outgrowing Drosophila renal tubules depends on signaling a subset tubule cells results from enhanced sensitivity to guidance signals by targeted matrix deposition. VEGF/PDGF ligands attract hemocytes, which secrete components basement membrane ensheath them. Collagen IV sensitizes localized BMP cues. Signaling pathway activation lead outgrowth through cavity....
There is limited knowledge on the extent and location of scarring that results from catheter ablation its role in suppressing atrial fibrillation (AF). We examined effect fibrosis ablation-induced outcomes AF.We conducted a prospective multicenter study enrolled 329 AF patients presenting for ablation. Delayed enhancement magnetic resonance imaging (DE-MRI) left atrium was obtained preablation. Scarring evaluated 177 with DE-MRI scan 90 days postablation. residual fibrosis, defined as...
Objective To profile RNA expression in gastric cancer by anatomic subsites as an initial step identifying molecular subtypes and providing targets for early detection therapy. Methods We performed transcriptome analysis using the Affymetrix GeneChip U133A cardia adenocarcinomas (n = 62) noncardia 72) their matched normal tissues from patients Shanxi Province, validated selected dysregulated genes with additional studies. Expression of was also related to survival cases. Results Principal...
Genome-wide association studies (GWAS) of gastric cancer have reported differences in single-nucleotide polymorphism (SNP) associations for tumour subtypes, particularly when divided by location into the cardia versus non-cardia.Here we present results a GWAS using 2350 East Asian cases as 1189 and 1027 non-cardia 2708 controls. We also included up to 3042 cases, 4359 7548 controls replication from two Chinese one Korean study. From GWAS, selected 12 top SNPs each subtype, 4 total 1 SNP MUC1...
// Mingfeng Zhang 1 , Zhaoming Wang 2,3,100 Ofure Obazee 4 Jinping Jia Erica J. Childs 5 Jason Hoskins Gisella Figlioli Evelina Mocci Irene Collins Charles C. Chung 2,3 Christopher Hautman Alan A. Arslan 6,7,8 Laura Beane-Freeman 2 Paige M. Bracci 9 Julie Buring 10,11 Eric Duell 12 Steven Gallinger 13 Graham G. Giles 14,15,16 Gary E. Goodman 17 Phyllis 18 Aruna Kamineni 19 Laurence N. Kolonel 20 Matthew H. Kulke 21 Núria Malats 22 Sara Olson 23 Howard D. Sesso 24,10,11 Kala...
In order to solve the problems of high subjectivity, frequent error occurrence and easy damage traditional corn seed identification methods, this paper combines deep learning with machine vision utilization basis Swin Transformer improve maize recognition. The study was focused on feature attention multi-scale fusion learning. Firstly, input image into network obtain shallow features features; secondly, a layer introduced give weights different stages strengthen suppress; finally, were fused...
Abstract Techniques that enable precise manipulations of subsets neurons in the fly central nervous system have greatly facilitated our understanding neural basis behavior. Split-GAL4 driver lines allow specific targeting cell types Drosophila melanogaster and other species. We describe here a collection 3060 range adult 1373 characterized third-instar larvae. These tools functional, transcriptomic, proteomic studies based on anatomical targeting. NeuronBridge search relate light microscopy...
Peripheral nerve injury (PNI)-induced neuropathic pain (NP) is a severe disease with high prevalence in clinics. Gene reprogramming and tissue remodeling the dorsal root ganglia (DRG) spinal cord (SC) drive development maintenance of (NP). However, our understanding NP-associated spatial molecular processing landscape SC non-synaptic interactions between DRG neurons cells remains limited. We here integrate transcriptomics (ST) single-nucleus RNA-sequencing (snRNA-seq) bulk (bulk RNA-seq) to...
A strategy for proteomic analysis of microdissected cells derived from human tumor specimens is described and demonstrated by using esophageal cancer as an example. Normal squamous epithelium corresponding two patients were procured laser-capture microdissection studied two-dimensional polyacrylamide gel electrophoresis (2D-PAGE). Fifty thousand resolved approximately 675 distinct proteins (or isoforms) with molecular weights ranging between 10 200 kDa isoelectric points pH 3-10. Comparison...