A5005035346- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Genetic factors in colorectal cancer
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Genetic Associations and Epidemiology
- Congenital gastrointestinal and neural anomalies
- DNA Repair Mechanisms
- Digestive system and related health
- Pancreatic and Hepatic Oncology Research
- Cancer-related Molecular Pathways
- Helicobacter pylori-related gastroenterology studies
- Folate and B Vitamins Research
- Liver Disease Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- RNA Research and Splicing
- Carcinogens and Genotoxicity Assessment
- Cancer, Lipids, and Metabolism
- COVID-19 Clinical Research Studies
- Estrogen and related hormone effects
- Intestinal Malrotation and Obstruction Disorders
- Colorectal Cancer Screening and Detection
- Lung Cancer Treatments and Mutations
- Microtubule and mitosis dynamics
- Nutrition, Genetics, and Disease
Wuhan University
2020-2025
Huazhong University of Science and Technology
2016-2025
Zhongnan Hospital of Wuhan University
2023-2025
Renmin Hospital of Wuhan University
2020-2025
Qingdao Binhai University
2025
Second Xiangya Hospital of Central South University
2013-2025
Central South University
2013-2025
Tianjin Medical University
2025
Tianjin Medical University Eye Hospital
2025
Shanghai Cancer Institute
2025
The outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, China, is serious and has the potential to become an epidemic worldwide. Several studies have described typical clinical manifestations including fever, cough, diarrhea, fatigue. However, our knowledge, it not been reported that patients with COVID-19 had any neurologic manifestations.
Significance Statement Although reports indicate that patients receiving maintenance hemodialysis are at risk for severe illness with coronavirus disease 2019 (COVID-19), information about this population of is limited. Using data retrospectively collected from a registration system included 7154 undergoing 65 hospitals in Wuhan, China, the authors found 154 had laboratory-confirmed COVID-19. In detailed analysis epidemiologic and clinical characteristics 131 COVID-19 who provided oral...
China has seen rapid socio-economic and epidemiolo-gical changes over the past several decades. Economicgrowth plus shifts in environment, lifestyles diethave increased life expectancy, but they have also ledto a higher burden of chronic, non-communicablediseases. Stroke, coronary heart disease (CHD), cancerand diabetes account for 80% deaths 70%of disability-adjusted life-years lost China.
Long non-coding RNAs (lncRNAs) play key roles in various cellular contexts and diseases by diverse mechanisms. With the rapid growth of identified lncRNAs disease-associated single nucleotide polymorphisms (SNPs), there is a great demand to study SNPs lncRNAs. Aiming provide useful resource about lncRNA SNPs, we systematically analyzed their potential impacts on structure function. In total, 495,729 777,095 more than 30,000 transcripts human mouse, respectively. A large number were predicted...
In December 2019, an outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) infection occurred in Wuhan, and rapidly spread to worldwide, which has attracted many people's concerns about patients. However, studies on status medical personnel is still lacking. A total 54 cases SARS-Cov-2 infected staff from Tongji Hospital between 7 January 11 February 2020 were analyzed this retrospective study. Clinical epidemiological characteristics compared different groups by...
Expression quantitative trait locus (eQTL) analysis, which links variations in gene expression to genotypes, is essential understanding regulation and interpreting disease-associated loci. Currently identified eQTLs are mainly samples of blood other normal tissues. However, no database comprehensively provides large number cancer samples. Using the genotype data 9196 tumor 33 types from The Cancer Genome Atlas (TCGA), we 5 606 570 eQTL-gene pairs cis-eQTL analysis 231 210 trans-eQTL...
Objective: This study was intended to investigate the relationship between COVID-19 disease and ovarian function in reproductive-aged women. Methods: Female patients of reproductive age were recruited January 28 March 8, 2020 from Tongji Hospital Wuhan. Their baseline clinical characteristics, as well menstrual conditions, recorded. Differentials reserve markers sex hormones (including anti-Müllerian hormone [AMH], follicle-stimulating [FSH], ratio FSH luteinizing [LH], estradiol [E2],...
Background & Aims: Overexpression of cyclooxygenase-2 (COX-2) is implicated in many steps cancer development. Single nucleotide polymorphisms (SNPs) the COX-2 promoter might contribute to differential expression and subsequent interindividual variability susceptibility cancer. This study sought identify functional SNPs evaluated their effects on risk developing esophageal squamous cell carcinoma (ESCC). Methods: Thirty individual DNA samples were sequenced search for SNPs, function was...
Abstract The etiology of esophageal squamous cell carcinoma (ESCC) has been shown to be associated with genetic and certain environmental factors that produce DNA damage. Base excision repair (BER) genes are responsible for damage caused by reactive oxygen species other electrophiles therefore good candidate susceptibility ESCC. We first screened eight BER new potential functional polymorphisms resequencing 27 samples. then identified genotyped important tagging single nucleotide (SNPs) in a...
Helicobacter pylori infection and the cytokine-mediated inflammatory responses play important roles in gastric cancer pathogenesis. This case control study was conducted to assess association between genetic polymorphisms interleukin (IL)-1B, IL-1RN, IL-8, IL-10 tumor necrosis factor alpha (TNFalpha), which are involved H.pylori infection, risk of cancer. Genotypes were determined by PCR-based denaturing high-performance liquid chromatography analysis direct DNA sequencing 250 incident cases...
The FAS receptor-ligand system is a key regulator of apoptotic cell death, and loss expression gain ligand (FASL) play important roles in the development progression cancer. Single-nucleotide polymorphisms promoter region (G or A at position -1377 [FAS -1377G/A] G -670 -670A/G]) FASL (T C -844 [FASL -844T/C]) genes alter transcriptional activity these genes. We examined association between risk metastasis esophageal squamous-cell carcinoma.Genotypes 588 case patients with carcinoma 648...
Abstract Matrix metalloproteinase-2 (MMP-2) plays important roles in cancer development and aggression. Our previous studies revealed a strong association between the MMP-2 −1306C/T polymorphism risk of several cancers. A novel −735C/T promoter has been identified but function is undefined. This study examined our hypothesis that these two polymorphisms might have functional relevance impact on esophageal squamous cell carcinoma context haplotype. Genotypes haplotypes were analyzed 527 cases...
Hirschsprung's disease (HSCR), or aganglionic megacolon, is a congenital disorder characterized by the absence of enteric ganglia in variable portions distal intestine. RET well-established susceptibility locus, although existing evidence strongly suggests additional loci contributing to sporadic HSCR. To identify these genetic loci, we carried out genome-wide association study using Affymetrix 500K marker set. We successfully genotyped 293,836 SNPs 181 Chinese subjects with HSCR and 346...
Abstract The tumor suppressor P53 pathway plays a crucial role in preventing carcinogenesis and genetic variations of this may be associated with cancer susceptibility. We tested hypothesis by examining the contribution functional polymorphisms MDM2 to risk esophageal squamous cell carcinoma (ESCC). DNA from 758 ESCC patients 1,420 controls were genotyped for codon 72Arg>Pro 309T>G polymorphisms. Odds ratios (OR) 95% confidence intervals (CI) estimated logistic regression....