A5100323687- MicroRNA in disease regulation
- COVID-19 and healthcare impacts
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Circular RNAs in diseases
- Effects of Radiation Exposure
- Porphyrin and Phthalocyanine Chemistry
- Synthesis and Properties of Aromatic Compounds
- Angiogenesis and VEGF in Cancer
- Natural product bioactivities and synthesis
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Diagnosis and Treatment
- Synthesis and properties of polymers
- COVID-19 Clinical Research Studies
- Lung Cancer Research Studies
- Silicone and Siloxane Chemistry
- Lung Cancer Treatments and Mutations
- Pharmacological Effects of Natural Compounds
- Radiation Dose and Imaging
- Axon Guidance and Neuronal Signaling
- Cancer Cells and Metastasis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Ginseng Biological Effects and Applications
- Cancer Diagnosis and Treatment
- Bacteriophages and microbial interactions
Chinese PLA General Hospital
2024-2025
Anhui Medical University
2009-2025
Xinjiang Medical University
2024
First Affiliated Hospital of Xinjiang Medical University
2024
Jilin University
2011-2022
University of Science and Technology of China
2022
Fifth Affiliated Hospital of Sun Yat-sen University
2020-2022
Sun Yat-sen University
2016-2022
Dongguan People’s Hospital
2022
Southern Medical University
2022
A method combining liquid–liquid phase separation and the pyrolysis process has been developed to fabricate wormhole-like porous carbon/magnetic nanoparticles composite with a pore size of about 80 nm (WPC/MNPs-80). In this work, structure was designed enhance interaction between electromagnetic (EM) wave absorber, while magnetic were used bring loss ability. The structure, morphology, porosity properties WPC/MNPs-80 investigated in detail. To evaluate its EM attenuation performance,...
Plant-based diets are increasingly recognized for cancer prevention, yet their specific impact on lung (LC) risk remains insufficiently examined. This study aims to assess the relationship between plant-based adherence and incidence of LC. Data from Prostate, Lung, Colorectal, Ovarian screening trial were analyzed. The diet index (PDI) was developed diets. Multivariable Cox regression model performed estimate hazard ratios (HRs) 95% confidence intervals (CIs). Restricted cubic spline (RCS)...
MicroRNAs (miRNAs) are a type of endogenous noncoding small RNAs involved in the regulation multiple biological processes. Recently, miR-29 was found to participate myogenesis. However, underlying mechanisms by which promotes myogenesis have not been identified. We here that significantly upregulated with age postnatal mouse skeletal muscle and during differentiation. Overexpression inhibited C2C12 myoblast proliferation promoted myotube formation. specifically targeted Akt3, member...
The epidemic of Coronavirus Disease 2019 (COVID-19) first broke out in Wuhan December 2019, and reached its peak February 2020. It became a major public health challenge for China, evolved into global pandemic March For radiation oncology departments, the COVID-19 presents unique disease protection prevention both patients staff, owing to weakened immune systems cancer need deliver timely uninterrupted radiotherapy. At Hubei Cancer Hospital, only hospital that specializes oncology, we...
MicroRNAs may function to promote or suppress tumor development, depending on the cellular context. The important role of microRNAs in regulating molecular pathways underlying tumorigenesis has been emphasized hepatocellular carcinoma (HCC). regulate gene expression via post-transcriptional mechanisms by inhibiting translation degrading mRNA. In this study, we show that microRNA-1 (miR-1) and microRNA-499 (miR-499) are capable repressing ets1 proto-oncogene, which plays a fundamental...
MicroRNAs (miRNAs) have been discovered to pivotal roles in regulating the drug resistance of various types human cancer, including cisplatin (DDP) non-small cell lung cancer (NSCLC). Fewer studies explored miR-106a NSCLC-cell DDP and its precise molecular mechanism has remained elusive. In present study, whether was able mediate line A549 investigated. Reverse transcription quantitative polymerase chain reaction used analyze mRNA expression levels. levels were upregulated DDP-resistant...
MicroRNAs (miRNAs) play important roles in the development of skeletal muscle. In our previous study, expression miR-195 and miR-497 were shown to be upregulated during muscle pigs. this we investigated these two miRNAs myogenesis analyzed their transcriptional regulation. Our results showed that myoblast differentiation. Moreover, inhibited proliferation but not differentiation C2C12 cells. Further investigation revealed Igf1r, Insr, Ccnd2 Ccne1 directly targeted by myoblasts. addition,...
Abstract The purpose of this study was to determine the correlation between over‐expression neuropilin 1 ( NRP 1) gene and growth, survival, radio‐sensitivity non‐small cell lung carcinoma NSCLC ) cells. 3‐[4,5‐dimethylthylthiazol‐2‐yl]‐2,5 diphenyltetrazolium broide (MTT) colony assays were then performed effect inhibition on in vitro growth Annexin V‐Fluorescein Isothiocyanate (FITC) apoptosis detection assay analyse enhancement Transwell invasion migration employed examine metastatic...
Abstract Purpose To determine the postoperative effects of radiotherapy (PORT) on local recurrence‐free survival (LRFS) and overall (OS) stage III‐N2 non‐small‐cell lung cancer (NSCLC). Materials Methods 183 patients with resected III‐pN2 NSCLC from Hunan Cancer Hospital between 2013 2016 were divided into two groups for chemotherapy (POCT) (n = 105) or combination (POCRT) 78). The LRFS OS compared factors affecting recurrence illustrated in these groups. sites failure based lobe primary...
Radiation has been shown to promote the epithelial-mesenchymal transition (EMT) in tumor cells, and TGF-β/Smad PI3K-Akt signaling pathways play an important role EMT. In this study, we investigated effects of neuropilin-1 (NRP1) on radiation-induced non-classical Smad lung cancer as well NRP1 invasion migration.Changes expression levels EMT markers (β-catenin, N-cadherin, vimentin) related transcription factors (Twist ZEB1) stably transfected cells were detected by Western blotting qPCR,...
Since December 2019, an increasing number of cases the 2019 novel coronavirus disease (COVID-19) infected by severe acute respiratory syndrome 2 (SARS-CoV-2) have been identified in Wuhan, a large city 11 million people central China[1Wu J.T. Leung K. G.M. Nowcasting and forecasting potential domestic international spread 2019-nCoV outbreak originating China: modelling study.Lancet. 2020; https://doi.org/10.1056/NEJMoa2001017Crossref Scopus (18381) Google Scholar, 2Zhu N. Zhang D. Wang W. et...
Cervical cancer is one of the most common gynecological malignancies worldwide. However, pathogenesis cervical remains to be fully elucidated. Increasing evidence shows that microRNAs (miRNAs) may involved in cancer. The present study tested hypothesis overexpression miRNA (miR)‑411 delay, whereas serine/threonine kinase 17a (STK17A) contribute to, development and progression through p53 pathway. tissues adjacent normal were obtained from 141 patients with following radiotherapy, efficacy...
AIMTo investigate whether the preoperative neutrophil-tolymphocyte ratio (NLR) could predict prognosis of hepatocellular carcinoma (HCC) patients with portal/ hepatic vein tumor thrombosis (PVTT/HVTT) after hepatectomy. METHODSThe study population included 81 HCC who underwent hepatectomy and were diagnosed PVTT/HVTT based on pathological examination.The demographics, laboratory analyses, histopathology data analyzed. RESULTSOverall survival (OS) disease-free (DFS) determined in a high (>...
Abstract Background Oral squamous cell carcinoma (OSCC) has been one of the most malignant cancers in head and neck region. Anlotinib is a tyrosine kinase inhibitor targeting several receptors such as vascular endothelial growth factor receptor (VEGFR), fibroblast (FGFR), platelet-derived (PDGFR) c-Kit. Here we investigated whether have any antitumor effect on oral cancer tried to explore explain possible mechanism. Methods Data from The Cancer Genome Atlas Gene Expression Omnibus database...
Three new dammarane-type triterpene ginsenosides, together with six known were isolated from the leaves of Panax ginseng C.A. Meyer. The saponins named as ginsenoside Rh₁₁, Rh₁₂, and Rh₁₃. Their structures elucidated (20S)-3β,6α,12β,20-tetrahydroxydammara-25-ene-24-one 20-O-β-d-glucopyranoside (1), (20S)-3β,12β,20,24,25-pentahydroxydammarane (2), (20S,23E)-3β,12β,20,25-tetrahydroxydammara-23-ene (3) on basis 1D 2D NMR experiments mass spectra. ginsenosides identified M(₇cd), Rg₆, Rb₃,...