A5107956145- Cancer Mechanisms and Therapy
- Genetic factors in colorectal cancer
- CAR-T cell therapy research
- Peptidase Inhibition and Analysis
- Colorectal Cancer Treatments and Studies
- Colorectal Cancer Surgical Treatments
- Cancer Immunotherapy and Biomarkers
- Gastric Cancer Management and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- interferon and immune responses
- Cytokine Signaling Pathways and Interactions
- Cancer Genomics and Diagnostics
- Lymphoma Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- Protein Degradation and Inhibitors
- Cancer Cells and Metastasis
- Multiple Myeloma Research and Treatments
- Mechanisms of cancer metastasis
- Electrocatalysts for Energy Conversion
- Advanced DC-DC Converters
- Multilevel Inverters and Converters
- Immunotherapy and Immune Responses
- Colorectal Cancer Screening and Detection
- Ubiquitin and proteasome pathways
- Metal complexes synthesis and properties
State Key Laboratory of Electrical Insulation and Power Equipment
2023-2025
Xi'an Jiaotong University
2003-2025
Second Hospital of Anhui Medical University
2023-2025
Nanjing Medical University
2022-2025
Nantong University
2024-2025
Takeda (United States)
2018-2025
Taizhou People's Hospital
2024-2025
China Academy of Space Technology
2024-2025
Tianjin University of Science and Technology
2025
Kunming University
2025
While the potential of patient-derived organoids (PDOs) to predict patients' responses anti-cancer treatments has been well recognized, lengthy time and low efficiency in establishing PDOs hamper implementation PDO-based drug sensitivity tests clinics. We first adapt a mechanical sample processing method generate lung cancer (LCOs) from surgically resected biopsy tumor tissues. The LCOs recapitulate histological genetic features parental tumors have expand indefinitely. By employing an...
Abstract The dense extracellular matrix (ECM) in solid tumors, contributed by cancer‐associated fibroblasts (CAFs), hinders penetration of drugs and diminishes their therapeutic outcomes. A sequential treatment strategy remodeling the ECM via a CAF modifier (dasatinib, DAS) is proposed to promote an immunogenic cell death (ICD) inducer (epirubicin, Epi) apoptotic vesicles, ultimately enhancing efficacy against breast cancer. Dendritic poly(oligo(ethylene glycol) methyl ether methacrylate)...
We assessed the Aurora A kinase inhibitor, alisertib, plus paclitaxel (henceforth referred to as alisertib/paclitaxel) second-line treatment for SCLC.In this double-blind study, patients with relapsed or refractory SCLC were stratified by relapse type (sensitive versus resistant refractory) and brain metastases randomized 1:1 alisertib/paclitaxel placebo placebo/paclitaxel) in 28-day cycles. The primary end point was progression-free survival (PFS). Associations of c-Myc expression tumor...
Extracellular matrix (ECM) is crucial in various biological functions during tumor progression, including induction of anoikis resistance and cell adhesion-mediated drug (CAM-DR). Fibronectin (FN) a vital ECM component with direct regulatory effects on ECM-mediated CAM-DR, making it an attractive innovative therapeutic target for depriving tissue. Herein, deprivation system (EDS) developed based FN targeting self-assembly peptide constructing nanofibers the renal carcinoma (RCC), which...
Measurable residual disease (MRD) evaluation may help to guide treatment duration in multiple myeloma (MM). Paradoxically, limited longitudinal data exist on MRD during maintenance. We investigated the prognostic value of dynamics 1280 transplant-eligible and -ineligible patients from TOURMALINE-MM3 -MM4 randomized placebo-controlled phase 3 studies 2-year ixazomib status at randomization showed independent (median progression-free survival [PFS], 38.6 vs 15.6 months MRD- MRD+ patients; HR,...
Abstract Background Epstein-Barr virus (EBV) is an oncovirus belonging to the herpesvirus family, associated with pathogenesis of multiple malignancies, particularly Burkitt lymphoma (BL). The remains latent in host cells and plays a critical role tumor progression through various mechanisms. A key glycoprotein, gp350, expressed during lytic phase EBV, instrumental viral entry into B presents unique antigenic target, making it promising candidate for immunotherapeutic approaches, such as...
Epithelial–mesenchymal transition (EMT) enables epithelial cells to acquire motility and invasiveness that are characteristic of mesenchymal cells. It plays an important role in development tumor cell metastasis. However, the mechanisms EMT their dysfunction cancer still not well understood. Here we report Siva1 interacts with stathmin, a microtubule destabilizer. inhibits stathmin's activity directly as indirectly through Ca 2+ /calmodulin-dependent protein kinase II-mediated...
Recent evidence indicates that inflammatory parameters could be useful to predict metastasis from colorectal cancer. However, their roles in predicting chemotherapy response and prognosis patients with synchronous liver (CLM) are unknown.The clinical data baseline laboratory of 55 CLM were retrospectively reviewed. All underwent palliative resection the primary tumor oxaliplatin-based chemotherapy. Two indices systemic inflammation reviewed-neutrophil-to-lymphocyte ratio (NLR)...
Both defects in mismatch repair (dMMR) and high microsatellite instability (MSI-H) have been recognised as crucial biomarkers that guide treatment strategies disease management colorectal cancer (CRC). As MMR MSI tests are being widely conducted, an increasing number of MSI-H tumours identified CRCs with proficiency (pMMR). The objective this study was to assess the clinical features patients pMMR/MSI-H CRC elucidate underlying molecular mechanism these cases. From January 2015 December...
Abstract Purpose Our study is to examine astrocyte‐elevated gene‐1 (AEG‐1) expression in triple‐negative breast cancer and determine whether it associated with vascular endothelial growth factor (VEGF), microvessel density (MVD), clinicopathological parameters poor survival. Methods Specimens from 125 patients cancers were investigated by immunohistochemistry for MVD, AEG‐1 VEGF expression. Correlations between the of AEG‐1, VEGF, various factors including survival status studied. Results...
The aim of this prospective, single-arm phase II trial was to confirm the safety and efficacy neoadjuvant chemotherapy (NAC) using oxaliplatin plus capecitabine (CapOX) for patients with operable locally advanced colon cancer (CC).Patients computed tomography-defined T4 or lymph node-positive CCs were enrolled. After radiological staging, treated at least 2 cycles NAC consisting 130 mg/m2 on d 1, 1,000 twice daily 14 every 3 weeks, followed by surgery, then rest adjuvant chemotherapy....
Background: Both AJCC 7th and 8th TNM systems have included tumor deposits (TDs) in nodal staging when lymph nodes metastases (LNMs) are negative colorectal cancer (CRC). However, the prognostic role of TDs has not been determined presence positive LNMs. Methods: Two independent large-scale cohorts CRC patients from Surveillance Epidemiology End Results (SEER) database (n=69,178) [2010–2013] Fudan University Shanghai Cancer Center (FUSCC) (n=3,137) [2010–2014] were retrospectively analyzed....
Bispecific T-cell engager (BiTE) molecules induce redirected lysis of cancer cells by T and are an emerging modality for solid tumor immunotherapy. While signs clinical activity have been demonstrated, efficacy engagers (TCEs) in tumors settings, molecular determinants response, underlying mechanisms resistance to BiTE therapy require more investigation.To uncover cell-intrinsic genetic modifiers TCE-mediated cytotoxicity, we performed genome-wide CRISPR (Clustered Regularly Interspaced...
Abstract Aqueous Mn‐ion batteries (MIBs) exhibit a promising development potential due to their cost‐effectiveness, high safety, and for energy density. However, the of MIBs is hindered by lack electrode materials capable storing Mn 2+ ions acidic manganese salt electrolytes large ion radius. Herein, tunnel‐type structure monoclinic VO 2 nanorods effectively store via reversible (de)insertion chemistry first time reported. Utilizing exhaustive in situ/ex situ multi‐scale characterization...
Co-inhibition of histone deacetylase (HDAC) and cyclin-dependent kinase (CDK) synergizes to produce enhanced antitumor effects potentially overcomes the drug resistance. In this work, we discovered a series novel CDK9/HDACs dual inhibitors. Among them, compound 8e was identified show potent CDK9 HDAC1 inhibitory activities, with IC50 values at 88.4 168.9 nM, respectively, exhibited antiproliferative capacities against hematological solid tumor cells. Meanwhile, showed high selectivity for...
This study was carried out to evaluate the effects of a Huaier polysaccharide (TP-1) on tumor growth and immune function in hepatocellular carcinoma (HCC) H22-based mouse vivo. Results showed that TP-1 capable repressing transplanted H22 solid hepatic cell vivo, prolonging live time mice bearing ascetic tumors, pulmonary metastasis H22-bearing mice. Moreover, relative weight organ (spleen thymus) lymphocyte proliferation were improved after treatment. Furthermore, treatment with could...
While genetic factors were associated with over 30% of colorectal cancer (CRC) patients, mutations in CRC-susceptibility genes identified only 5% to 10% these patients. Besides, previous studies on hereditary CRC largely designed analyze germline patients single high-risk factor, which limited understanding the association between genotype and phenotypes. From January 2015 December 2018, we retrospectively enrolled 2,181 from 8,270 consecutive cases, covering 5 categories factors. Leukocyte...
LAPTM4B is a novel tumor-associated gene. To date, there have been no published data regarding the role of expression in epithelial ovarian carcinoma metastasis. Therefore, this study was performed to determine whether overexpression new predictor evaluated 22 normal specimens and 139 carcinomas by western blotting analyses immunohistochemistry. Univariate multivariate were used association between Western analysis demonstrated that overexpressed metastatic tissues from patients with...
Objective: Despite advances in chemotherapy and cytoreductive surgery, ovarian cancer remains the most lethal gynecological malignancy with a 5-year survival rate of 25% to 30% advanced stage disease. Our purpose is evaluate whether astrocyte elevated gene-1 (AEG-1) novel predictor peritoneal dissemination lymph node metastasis epithelial (EOC), which was not previously studied by others. Materials Methods: Through immunohistochemical Western blot analysis, AEG-1 expression evaluated 25...
Astrocyte elevated gene-1 (AEG-1) is an important force in the development and progression of hepatocellular carcinoma (HCC). To extend our study, we examined here role AEG-1 anti-metastatic effects Huaier polysaccharide (HP) on human HCC MHCC97-H cell line. shRNA contributed to anti-proliferation effect HP cells. Furthermore, results Transwell insert chambers showed that low expression could effectively facilitate suppress migration invasion. We achieved this by reducing phosphoinositide...