A5101741970- Obstructive Sleep Apnea Research
- Neuroscience and Neuropharmacology Research
- Virus-based gene therapy research
- Acute Myeloid Leukemia Research
- Alzheimer's disease research and treatments
- CAR-T cell therapy research
- Blood disorders and treatments
- Child Nutrition and Feeding Issues
- Protein Degradation and Inhibitors
- Histone Deacetylase Inhibitors Research
- Probiotics and Fermented Foods
- Clostridium difficile and Clostridium perfringens research
- Organ Donation and Transplantation
- Plant chemical constituents analysis
- Coronary Artery Anomalies
- Neuropeptides and Animal Physiology
- Gastrointestinal motility and disorders
- Lymphoma Diagnosis and Treatment
- Cardiovascular Issues in Pregnancy
- Neuroscience of respiration and sleep
- Morinda citrifolia extract uses
- Kawasaki Disease and Coronary Complications
- Gynecological conditions and treatments
- Immune cells in cancer
- Ergonomics and Musculoskeletal Disorders
Second Hospital of Anhui Medical University
2024-2025
Anhui Medical University
2024-2025
Jining First People's Hospital
2024-2025
Tianjin Medical University General Hospital
2025
Northeastern University
2024
Beijing University of Chinese Medicine
2023
First Affiliated Hospital of Xinxiang Medical University
2018-2023
Xinxiang Medical University
2023
Affiliated Hospital of North Sichuan Medical College
2023
Urumqi 4th People's Hospital
2022
Abstract Background Epstein-Barr virus (EBV) is an oncovirus belonging to the herpesvirus family, associated with pathogenesis of multiple malignancies, particularly Burkitt lymphoma (BL). The remains latent in host cells and plays a critical role tumor progression through various mechanisms. A key glycoprotein, gp350, expressed during lytic phase EBV, instrumental viral entry into B presents unique antigenic target, making it promising candidate for immunotherapeutic approaches, such as...
Acute Myeloid Leukemia (AML) is a prevalent neoplastic disorder. The roles of E3 ubiquitin ligases and related genes in AML drug resistance prognosis remain unclear. Genes were identified from GeneCards UniProt databases, differentially expressed selected based on transcriptional sequencing data wild-type Adriamycin-resistant HL60 (HL60/WT & HL60/ADR) cell lines, the intersection these three sources was taken. We then constructed prognostic model comprising five (HBP1, RNF130, RMND5B,...
The primary challenges in CD19-specific chimeric antigen receptor T-cell (CD19 CAR T) therapy for patients with refractory/relapsed B-cell acute lymphoblastic leukemia (r/r B-ALL) are non-response and relapse; it is urgent to reveal these mechanisms. Neutrophils play a critical role the immunosuppressive tumor microenvironment (TME), which can hinder T efficacy. Our previous research identified subset of neutrophils special phenotype (CD14-CD10-CD45-HLA-DR-SSC++, termed CD10- neuts),...
Chlamydia trachomatis (CT) is a major sexually transmitted pathogen with severe complications. Using muridarum (CM) as model, this study evaluates the attenuated mutant (CM-pGP3S) novel rectal vaccine to protect against genital tract infection and pathology. Female C57BL/6 mice were rectally immunized low (1×103), middle (1×105), or high (1×107) doses of CM-pGP3S. Mice challenged intravaginally wild-type 63 days post-immunization. Protection was assessed via shedding, hydrosalpinx incidence...
Abstract Objective The roles of hippocampal AMPAR s were investigated in irritable bowel syndrome ( IBS )‐like rats to clarify the central sensitization mechanisms. Methods model was induced by neonatal maternal separation. effects on visceral hypersensitivity examined responses abdominal muscle colorectal distension after bilateral intrahippocampal injections CNQX (an inhibitor). expressions (GluR1 and GluR2) determined Western blot. Results ‐like showed when compared with controls....
Based on multimodal measurement methods of NASA task load index (NASA-TLX), performance, surface electromyography (sEMG), heart rate (HR), and functional near-infrared spectroscopy (fNIRS), this study conducted experimental measurements analyses under 16 different levels physical fatigue mental combination conditions. This observed the interaction between at levels, subjective level, effect was greater than that fatigue. Secondly, results fNIRS analysis showed premotor cortex is affected by...
Alzheimer's disease (AD), a neurodegenerative affecting the elderly, frequently causes cognitive impairment and memory decline, there are currently no effective therapeutic drugs available. Glutamate excitotoxicity is one of pathogeneses AD, evidence that glutamic-oxaloacetic transaminase (GOT) can significantly reduce glutamate concentrations in hippocampi mice, but its role APP/PS1 transgenic mice unknown. We investigated improvement neurological function related protein expression...
<b><i>Background:</i></b> Allergic rhinitis is an allergic inflammation of the nasal airways, and chronic rhinosinusitis paranasal sinuses. It can be induced by infection, allergy, or autoimmune problems. Diagnosis these two diseases made primarily based on clinical symptoms, allergen test, imaging. The test invasive expensive. imaging harmful to children. Measurement nitric oxide (NNO) was noninvasive, without radiation, inexpensive. This study evaluate significance...
This study observed the inhibitory effect of Lactobacillus plantarum YS-4 (LP-YS4) on colitis through mice which was induced by DDS (Dextran Sulfate Sodium). By observing colon shape mice, test kit and quantitative PCR (polymerase chain reaction) technique were used to detect LP-YS4 compared with positive control drug sulfasalazine. The results showed that can increase length improve ratio weight/ length. tests serum could reduce Endothelin (ET), Substance P (SP), Interleukin-10 (IL-10)...
This study aimed to explore the clinical significance of CD45+CD33+CD14-CD10-HLA-DR-/low neutrophils (Cluster Differentiation 10 [CD10-] neutrophils) in B-cell non-Hodgkin's lymphoma (B-NHL). An amplification system CD10- vitro was constructed using cytokines, and mechanisms underlying cytokine-induced expansion activation neutrophil subpopulation were investigated. We identified a novel suppressive cell population known as peripheral blood patients with B-NHL different statuses by flow...
To investigate the presence of p53 gene deletion in Xinjiang patients with chronic lymphocytic leukemia and its clinical significance.Interphase fluorescence situ hybridization (FISH) was used to detect 77 CLL. Presence association laboratory features as well prognostic factors were analyzed. Kaplan-Meier method calculate survivals, results compared using a Log-rank test.p53 found 10 (12.9%) but none from control group (P<0.05). The 12.5% (4/32) ethnic Hans 13.3% (6/45) Uyghurs (P>0.05). No...
Multiple myeloma (MM) , also known as plasmacytoma, is a malignant tumor that originates from plasma cells in the bone marrow. The incidence of MM shows an upward trend year by year, and epidemiological data are still lacking our country. There many related factors disease, cause not clear. Compared with morbidity mortality, etiology more sensitive to changes. Therefore, it important explore risk factors. This article reviews regional, time, age, gender, ethnic distribution at home abroad,...