A5101626459- Health disparities and outcomes
- Vaccine Coverage and Hesitancy
- SARS-CoV-2 and COVID-19 Research
- Chronic Disease Management Strategies
- COVID-19 epidemiological studies
- Diet, Metabolism, and Disease
- Colorectal and Anal Carcinomas
- Urban Green Space and Health
- Pancreatitis Pathology and Treatment
- Liver Disease Diagnosis and Treatment
- Alcohol Consumption and Health Effects
- Land Use and Ecosystem Services
- Radiomics and Machine Learning in Medical Imaging
- Colorectal Cancer Surgical Treatments
- Health and Wellbeing Research
- Cardiac Ischemia and Reperfusion
- Inflammatory mediators and NSAID effects
- Adipokines, Inflammation, and Metabolic Diseases
- Genetic Associations and Epidemiology
- Physical Activity and Health
- Gout, Hyperuricemia, Uric Acid
- Traditional Chinese Medicine Studies
- HIV Research and Treatment
- Dietary Effects on Health
- Colorectal Cancer Treatments and Studies
Sun Yat-sen University
2018-2025
Zhujiang Hospital
2025
Southern Medical University
2025
Affiliated Hospital of North Sichuan Medical College
2023-2024
Shaanxi University of Chinese Medicine
2017-2023
Gansu Provincial Hospital
2015-2023
Ningxia Medical University
2015-2023
North Sichuan Medical University
2023
Ningxia Medical University General Hospital
2023
Shanghai Jiao Tong University
2016-2022
Abstract Statins play an important role in the treatment of diabetic nephropathy. Increasing attention has been given to relationship between statins and insulin resistance, but many randomized controlled trials confirm that therapeutic effects on nephropathy are more beneficial than harmful. However, further confirmation whether chronic statin administration outweigh detrimental is urgently needed. Here, we find long-term may increase interfere with lipid metabolism, leads inflammation...
Body mass index (BMI) and lipid parameters are the most commonly used anthropometric biomarkers for assessing nonalcoholic fatty liver disease (NAFLD) risk. This study aimed to assess quantify mediating role of traditional non-traditional on association between BMI NAFLD.Using data from 14,251 subjects NAGALA (NAfld in Gifu Area, Longitudinal Analysis) study, mediation analyses were performed explore roles [total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL-C),...
Aims . To examine whether hydrogen sulfide (H 2 S) generation changed in ageing diabetic mouse hearts. Results Compared to mice that were fed tap water only, 30% fructose solution for 15 months exhibited typical characteristics of a severe phenotype with cardiac hypertrophy, fibrosis, and dysfunction. H S levels plasma, heart tissues, urine significantly reduced these as compared those controls. The expression the S-generating enzymes, cystathionine γ -lyase 3-mercaptopyruvate...
Abstract Background Functional disability and multimorbidity are common among older people. However, little is known about the relationship between functional different combinations. We aimed to identify patterns explore associations these disability. Methods investigated a multi-stage random sample of 1871 participants aged ≥60 years covered by long-term care insurance in Shanghai, China. Multimorbidity was defined as simultaneous presence two or more chronic diseases an individual....
Neutrophil extracellular traps (NETs) have been categorized as a form of inflammatory cell death mode neutrophils (NETosis) involved in natural immunity and the regulation adaptive immunity. More more studies revealed ability NETs to reshape tumor immune microenvironment (TIME) by limiting antitumor effector cells, which may impair efficacy immunotherapy. To explore whether NETs-related genes make vital impacts on Colon carcinoma (COAD), we carried out systematic analysis showed several...
Background: Little is known about the pathophysiological diversity of myocardial injury in type 2 diabetes mellitus (T2DM), but analyzing these differences important for accurate diagnosis and precise treatment diabetic cardiomyopathy. This study aimed to elucidate key cardiac between obese non-obese T2DM from mice humans. Methods: Obese mouse models were successfully constructed observed until systolic dysfunction occurred. Changes structure, function, energy metabolism oxidative stress...
Diabetes (especially Type II) is one of the primary threats to cardiovascular health. Wound healing defects and vascular dysfunction are common in diabetic patients, cause deterioration sustained high plasma glucose. microRNA, a noncoding RNA, has regulatory functions that critical maintaining homeostasis. MicroRNA (miR)-126-3p potential diabetes biomarker proangiogenic factor, its level decreases patients. Previous studies have revealed character gasotransmitter hydrogen sulfide (H2S)....
BACKGROUND Older migrants in China without local resident registration ( hukou ) are a vulnerable population and face barriers to receiving healthcare. OBJECTIVES We aimed quantify the disparities healthcare utilization between older residents Shanghai, China. DESIGN This was cross‐sectional study. SETTING The study conducted China, 2016. PARTICIPANTS adults (aged ≥60 years) were recruited based on three‐stage stratified cluster sampling method (2571 locals 1920 migrants). MEASUREMENTS...
Purpose Obesity-related asthma poses serious health problems. Blood metabolite concentrations play crucial roles in its development, but the association with obesity-related risk is unclear. This study aimed to explore causal effect of blood levels on this risk.
BACKGROUND: Individuals with diabetes are susceptible to cardiac dysfunction and heart failure, potentially resulting in mortality. Metabolic disorders frequently occur patients diabetes, usually leads remodeling of structure dysfunction. However, the contribution underlying mechanisms metabolic structural coupling diabetic remain elusive. METHODS: Two mouse models type 2 (T2DM) were used assess alterations glucose/lipid metabolism structure. The potential metabolic-structural molecule ACBP...
Background The non-high-density lipoprotein cholesterol to high-density ratio (NHHR) has emerged as a promising biomarker for lipid metabolism, with established links mortality in various chronic diseases. However, its prognostic value individuals non-hyperhomocysteinemia (NHHcy), population often overlooked cardiovascular risk assessment, remains unexplored. This study aimed determine the association between NHHR and all-cause disease (CVD) predictive among adults NHHcy. Methods used...
// Huiping Yuan 1 , Xinghui Li 1, 2 Gang Wan 3 Liang Sun Xiaoquan Zhu Fugang Che and Ze Yang The MOH Key Laboratory of Geriatrics, Beijing Hospital, National Center Gerontology, Beijing, P.R. China College Public Health, Shaanxi University Chinese Medicine, Xianyang, Statistical Room, Ditan Hospital Capital University, Correspondence to: Yuan, email: yuanhuiping@126.com Yang, yang_ze@sina.com Keywords: type diabetes; prevalence; epidemic features; risk factors; temporal variation trend...
Background: Multiple SARS-CoV-2 variants are still rampant across the United States (US). We aimed to evaluate impact of vaccination scale-up and potential reduction in effectiveness on COVID-19 epidemic social restoration US. Methods: extended a published compartmental model calibrated latest US data. estimated vaccine against variant evaluated epidemics. explored trends under different levels restoration. Results: overall existing as 88.5% (95% CI: 87.4–89.5%) with coverage 70% by end...
Statins therapy is efficacious in diminishing the risk of major cardiovascular events diabetic patients. However, our research has uncovered a correlation between prolonged administration statins and an elevated myocardial dysfunction patients with type II diabetes mellitus (TIIDM). Here, we report induction sterol regulatory element-binding protein 1 (SREBP1) activation, associated lipid peroxidation, consequent after statin treatment explored underlying mechanisms. In db/db mice, observed...
Extracorporeal pulsed electromagnetic field (PEMF) has shown the ability to regenerate tissue by promoting cell proliferation. In present study, we investigated for first time whether PEMF treatment could improve myocardial ischaemia/reperfusion (I/R) injury and uncovered its underlying mechanisms. our demonstrated that extracorporeal a novel effect on I/R injury. The number function of circulating endothelial progenitor cells (EPCs) were increased in treating rats. vivo results showed...
Abstract Background Few studies have explored patterns of physical activity (PA) and examined their relationship with depression among community-dwelling older adults. We aimed to identify the PA through a person-centered analytical approach examine association between quantity PA, Methods conducted cross-sectional survey study in Minhang district, Shanghai, China, August 2019, used self-administered questionnaire collect data home visits. The total sample included 2525 This Physical...
The aesthetic value of 35 plant landscape samples Jinlong lake wetland park in Xuzhou city China were evaluated with principal factor analysis and SBE method. results showed that: fluctuated greatly the evaluation did not change much. order mean values different types was: on both sides roads > beside buildings surroundings typical community waterfront landscape. method contained more than 90% information seven factors, while mainly from “plant factors”. satisfaction was low,...