A5100434028- HIV/AIDS Research and Interventions
- HIV, Drug Use, Sexual Risk
- Particle physics theoretical and experimental studies
- Quantum Chromodynamics and Particle Interactions
- Reproductive tract infections research
- Hepatitis B Virus Studies
- High-Energy Particle Collisions Research
- Liver Disease Diagnosis and Treatment
- HIV Research and Treatment
- COVID-19 epidemiological studies
- Hepatitis C virus research
- Sex work and related issues
- Adolescent Sexual and Reproductive Health
- Syphilis Diagnosis and Treatment
- Cervical Cancer and HPV Research
- SARS-CoV-2 and COVID-19 Research
- Air Quality and Health Impacts
- Glaucoma and retinal disorders
- COVID-19 Clinical Research Studies
- HIV/AIDS drug development and treatment
- Retinal Diseases and Treatments
- Immunotherapy and Immune Responses
- Drug Transport and Resistance Mechanisms
- Gastric Cancer Management and Outcomes
- Cancer Immunotherapy and Biomarkers
Jinan Central Hospital
2020-2025
Xi'an Jiaotong University
2016-2025
Alfred Health
2016-2025
Centre for Eye Research Australia
2018-2025
Monash University
2016-2025
Melbourne Sexual Health Centre
2016-2025
Anhui Medical University
2013-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2011-2025
Second Affiliated Hospital of Nanjing Medical University
2023-2025
Nanjing University
2010-2025
Since the SARS outbreak 18 years ago, a large number of severe acute respiratory syndrome related coronaviruses (SARSr-CoV) have been discovered in their natural reservoir host, bats. Previous studies indicated that some those bat SARSr-CoVs potential to infect humans. Here we report identification and characterization novel coronavirus (nCoV-2019) which caused an epidemic humans, Wuhan, China. The epidemic, started from December 12th, 2019, has 198 laboratory confirmed infections with three...
<h3>Objective</h3> The associations between oral diseases and increased risk of pancreatic cancer have been reported in several prospective cohort studies. In this study, we measured variations salivary microbiota evaluated their potential with chronic pancreatitis. <h3>Methods</h3> This study was divided into three phases: (1) microbial profiling using the Human Oral Microbe Identification Microarray to investigate variation 10 resectable patients matched healthy controls, (2)...
Coronavirus disease 2019 (COVID-19) most commonly presents with respiratory symptoms, including cough, shortness of breath, and sore throat. However, digestive symptoms also occur in patients COVID-19 are often described outpatients less severe disease. In this study, we sought to describe the clinical characteristics mild severity.We identified one or more (diarrhea, nausea, vomiting), without compared them a group presenting solely symptoms. We followed up clinically until they tested...
Continuous glucose monitoring (CGM) has provided new measures of glycemic control that link to diabetes complications. This study investigated the association between time in range (TIR) assessed by CGM and diabetic retinopathy (DR).A total 3,262 patients with type 2 were recruited. TIR was defined as percentage spent within 3.9-10.0 mmol/L during a 24-h period. Measures variability (GV) well. DR determined using fundus photography graded 1) non-DR; 2) mild nonproliferative (NPDR); 3)...
Contamination with pathogenic and infectious viruses severely threatens human health animal husbandry. Current methods for disinfection have different disadvantages, such as inconvenience contamination of by-products (e.g., chlorine disinfection). In this study, atmospheric surface plasma in argon mixed air plasma-activated water was found to efficiently inactivate bacteriophages, still had strong antiviral activity after prolonged storage. Furthermore, it shown that bacteriophage...
A sensitive assay to identify biomarkers using non-invasively collected clinical specimens is ideal for breast cancer detection. While there are other studies showing disease in saliva cancer, our study tests the hypothesis that discriminatory de novo discovery and validation approaches. This first of this kind no has engaged a biomarker approach In study, case-control independent preclinical validations were conducted evaluate performance translational utilities salivary transcriptomic...
New WHO guidelines recommend ART initiation for HIV-positive persons with CD4 cell counts ≤500 cells/µL, a higher threshold than was previously recommended. Country decision makers must consider whether to further expand eligibility accordingly.We used multiple independent mathematical models in four settings-South Africa, Zambia, India, and Vietnam-to evaluate the potential health impact, costs, cost-effectiveness of different adult criteria under scenarios current expanded treatment...
We present a timely evaluation of the Chinese 2019-nCov epidemic in its initial phase, where demonstrates comparable transmissibility but lower fatality rates than SARS and MERS. A quick diagnosis that leads to case isolation integrated interventions will have major impact on future trend. Nevertheless, as China is facing Spring Festival travel rush has spread beyond borders, further investigation potential spatiotemporal transmission pattern novel intervention strategies are warranted.
Diabetes mellitus is a common chronic disease and severe public health issue. The incidence trends for type 1 diabetes (TIDM) 2 (T2DM) have rarely been studied on global scale. We aimed to determine the temporal geographical of globally.Data mellitus, including incidence, prevalence from 1990 2017 were obtained Global Burden Disease study. calculated estimated annual percentage changes (EAPCs) in age-standardized rate (ASIR) according sex, region, type.The worldwide incident cases has...
A new coronavirus disease (COVID-19) with infection by a novel named severe acute respiratory syndrome 2 (SARS-CoV-2) has spread globally since December 2019. By 22 September 2020, more than 200 countries worldwide have reported about 30 million confirmed cases and 950,000 deaths.1World Health OrganizationCoronavirus (COVID-2019) situation reports.https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports/Google Scholar China total of 85,307 (including 2,758 imported)...
During the outbreak of COVID-19, national policy home quarantine may affect mental health parents. However, few studies have investigated parents during COVID-19 pandemic.To investigate depression, anxiety and stress students' pandemic, to explore influence factors, especially social support family-related factors.The Generalised Anxiety Disorder-7, Patient Health Questionnaire-9, Perceived Stress Scale-10 Social Support Rating Scale were applied 1163 measure parents' anxiety, support.(1)...
Inflammation plays an integral role in carcinogenesis and tumor progression. Inflammatory response biomarkers have shown to be promising prognostic factors for improving the predictive accuracy various cancers. The aim of this study is investigate significance pre-operative neutrophil lymphocyte ratio (NLR), derived (dNLR), platelet (PLR) monocyte (LMR) gastric cancer (GC).389 patients who had undergone gastrectomy were enrolled from 2007 2009 study. NLR, dNLR, PLR LMR calculated peripheral...
This study projects the trend of disease burden and economic diabetes in 33 Chinese provinces nationally during 2020-2030 investigates its spatial disparities.Time series prediction on prevalence disability-adjusted life-year (DALY) rates was conducted using a Bayesian modelling approach 2020-2030. The top-down method human capital were used to predict direct indirect costs for each province. Global local autocorrelation analyses identify geographic clusters low-or high-burden areas.Diabetes...
Dietary fibers/probiotics may relieve constipation via optimizing gut microbiome, yet with limited trial-based evidences. We aimed to evaluate the effects of formulas dietary fibers or probiotics on functional symptoms, and identify modulations microbiota relevance. conducted a 4-week double-blinded randomized placebo-controlled trial in 250 adults constipation. Intervention: A: polydextrose; B: psyllium husk; C: wheat bran + D: Bifidobacterium animalis subsp. lactis HN019 Lacticaseibacillus...
Abstract Aims/hypothesis The study aims to quantify the global trend of disease burden type 2 diabetes caused by various risks factors country income tiers. Methods Data on diabetes, including mortality and disability-adjusted life years (DALYs) during 1990–2019, were obtained from Global Burden Disease Study 2019. We analysed DALY rates population attributable fraction (PAF) in risk Results Globally, age-standardised death rate (ASDR) increased 16.7 (15.7, 17.5)/100,000 person-years 1990...
Structural variations (SVs) are a major contributor to genetic diversity and phenotypic variations, but their prevalence functions in domestic animals largely unexplored. Here we generated high-quality genome assemblies for 15 individuals from genetically diverse sheep breeds using Pacific Biosciences (PacBio) high-fidelity sequencing, discovering 130.3 Mb nonreference sequences, which 588 genes were annotated. A total of 149,158 biallelic insertions/deletions, 6531 divergent alleles, 14,707...
Parkinson's disease (PD) has become a public health concern with global ageing. However, comprehensive assessments of the temporal and geographical trend PD burden in China remain insufficient. This study aimed to examine by age, gender, region during 1990-2021.