A5013665491- Diabetes Management and Research
- Diabetes and associated disorders
- Diabetes Treatment and Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Pancreatic function and diabetes
- Ophthalmology and Eye Disorders
- Glaucoma and retinal disorders
- Gestational Diabetes Research and Management
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Diabetes Management and Education
- Cardiovascular Health and Disease Prevention
- Pituitary Gland Disorders and Treatments
- Sirtuins and Resveratrol in Medicine
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Salivary Gland Disorders and Functions
- Cardiovascular Function and Risk Factors
- Diet and metabolism studies
- Mesenchymal stem cell research
- Advanced Glycation End Products research
- Mobile Health and mHealth Applications
- Cerebral Venous Sinus Thrombosis
- Nutrition and Health in Aging
- Cardiac Fibrosis and Remodeling
- Tissue Engineering and Regenerative Medicine
Shanghai Jiao Tong University
2016-2025
International Peace Maternity & Child Health Hospital
2020-2025
Shanghai Sixth People's Hospital
2011-2024
Shanghai Clinical Research Center
2020-2024
Diabetes Foundation
2020-2024
XinHua Hospital
2015-2024
Tongji University
2024
Second Affiliated Hospital of Zhejiang University
2014-2023
Ruijin Hospital
2014-2022
Wuhan No.1 Hospital
2022
Continuous glucose monitoring (CGM) has provided new measures of glycemic control that link to diabetes complications. This study investigated the association between time in range (TIR) assessed by CGM and diabetic retinopathy (DR).A total 3,262 patients with type 2 were recruited. TIR was defined as percentage spent within 3.9-10.0 mmol/L during a 24-h period. Measures variability (GV) well. DR determined using fundus photography graded 1) non-DR; 2) mild nonproliferative (NPDR); 3)...
Background: Time in range (TIR) is an emerging metric of glycemic control and reported to be associated with microvascular complications diabetes. We sought investigate the association TIR obtained from continuous glucose monitoring (CGM) carotid intima-media thickness (CIMT) as a surrogate marker cardiovascular disease (CVD). Methods: Data 2215 patients type 2 diabetes were cross-sectionally analyzed. 3.9-10.0 mmol/L was evaluated CGM. CIMT measured using high-resolution B-mode...
There is growing evidence linking time in range (TIR), an emerging metric for assessing glycemic control, to diabetes-related outcomes. We aimed investigate the association between TIR and mortality patients with type 2 diabetes.A total of 6,225 adult diabetes were included from January 2005 December 2015 a single center Shanghai, China. was measured continuous glucose monitoring at baseline, participants stratified into four groups by TIR: >85%, 71-85%, 51-70%, ≤50%. Cox proportional...
Mesenchymal stem cells (MSCs) senescence is an age-related process that impairs the capacity for tissue repair and compromises clinical use of autologous MSCs regeneration. Here, we describe effects SIRT1, a NAD(+)-dependent deacetylase, on senescence. Knockdown SIRT1 in young induced cellular inhibited cell proliferation whereas overexpression aged reversed phenotype stimulated proliferation. These results suggest plays key role modulating age-induced Aging-related proteins, P16 P21 may be...
For patients with active moderate-to-severe Graves' ophthalmopathy (GO), a course of 4.5 g iv glucocorticoids (GCs) is the recommended therapy. The weekly protocol preferred because potential safety concerns daily protocol. However, evidence for superiority different administration protocols lacking.We conducted prospective, randomized trial to compare efficacy and two methylprednisolone in total 80 our institute. were receive or daily. response rate (a composite endpoint including lid...
The association between inflammatory indices from peripheral blood cell in early pregnancy and the risk of gestational diabetes mellitus (GDM) is unclear. This was a retrospective study involving medical data 15,807 pregnant women who gave birth 2019. Data were collected records analyzed. women's age, educational level, pre-pregnancy body weight, height, parity, family history diabetes, lipid profile, pressure recorded during 11 ~ 13+ 6 weeks. We measured several easily accessible systemic...
The relationship between glycemic variability (GV) and diabetic complications has gained much interest remains under debate. Furthermore, the association of GV with not been examined in latent autoimmune diabetes adult (LADA). Therefore, we evaluated relationships among several metrics retinopathy (DR) patients LADA type 2 mellitus.A total 192 2,927 mellitus were enrolled. After continuous glucose monitoring for 72 h, three including standard deviation, coefficient variation mean amplitude...
In recent years, the rapid development of mobile medical technology has provided multiple ways for long-term management chronic diseases, especially diabetes. As a new type model, smartphone apps are global, convenient, cheap, and interactive. Although were proved to be more effective at glycemic control, compared with traditional computer- Web-based telemedicine technologies, how gain further sustained improvement is still being explored.
Abstract Aim To investigate the association between a new composite metric, glycaemia risk index (GRI), and incident diabetic retinopathy (DR). Methods A total of 1204 adults with type 2 diabetes without DR at baseline were included 2005 2019 from single centre in Shanghai, China. GRI was obtained continuous glucose monitoring data baseline. Cox proportion hazard regression analysis used to assess DR. Results During median follow‐up 8.4 years, 301 patients developed The...
Type 2 diabetes is a complex metabolic disease and has been shown to involve alteration of the gut microbiota. Previous studies have primarily focused on changes in bacterial microbiome, while ignoring phage community composition. Extracellular phages can lyse host bacteria thus influence microbiota through positive or negative interactions with bacteria. We investigated extracellular phageome discussed its role T2D pathogenesis. used sequencing-based approach identify bacteriophage after...
Adrenal venous sampling is recommended as the golden standard for subtyping primary aldosteronism (PA). However, it invasive and inconvenient, seeking a better way to make differential diagnosis of PA necessary.The objective study was evaluate diagnostic value ACTH stimulation test under 1 mg dexamethasone suppression (DST) in determining subtypes PA.Ninety-five patients with confirmed by saline infusion were included this study. According adrenal histopathology, 39 diagnosed bilateral...
Aims Activation of cardiac fibroblasts into myofibroblasts constitutes a key step in remodeling after myocardial infarction (MI), due to interstitial fibrosis. Mesenchymal stem cells (MSCs) have been shown improve post-MI an effect that is enhanced by hypoxia preconditioning (HPC). Leptin has promote The expression leptin significantly increased MSCs HPC but it unknown whether contributes MSC therapy or the fibrosis process. objective this study was determine secreted from modulates Methods...
<h3>Background</h3> Previous studies have shown that smoking is closely related to the occurrence, severity and response orbital radiation in Graves' ophthalmopathy (GO). The aim of this study was investigate whether impacts intravenous 4.5 g methylprednisolone therapy patients with active moderate-to-severe GO. <h3>Methods</h3> Ninety-two individuals GO who were treated cumulative doses within 3 months recruited. grouped as never smokers, smokers (including quit smokers) passive smokers....
A-FABP (adipocyte fatty acid-binding protein), one of the most abundant proteins in adipocytes, plays a key role obesity-related insulin resistance, inflammation and atherosclerosis animals. In present study, we sought to investigate association with HF (heart failure) Chinese subjects. Serum levels were measured 252 patients 261 age-, gender- BMI (body mass index)-matched non-HF Echocardiography was performed on each patient. The severity determined by NYHA (New York Heart Association)...
SIRT1 has been proved to rejuvenate and improve the therapeutic efficacy of aged rat mesenchymal stem cells (MSCs). Herein, we investigate protective effect pretreatment with activator SRT1720 on human MSCs (hMSCs). The optimized condition for hMSCs was determined be 0.5 μM 24 h by monitoring survival subjected serum deprivation±hypoxia and±500 hydrogen peroxide (H2O2). Pretreatment these conditions increased 1 day (2.7-fold) 3 days (1.9-fold) after being transplanted into a myocardial...
Abstract Background Clinical and basic investigations have indicated a significant association between circulating growth differentiation factor 15 (GDF15) cardiovascular disease; however, the relationship GDF15 lower extremity atherosclerotic disease (LEAD) has been less studied. The present study aimed to explore LEAD in Chinese patients with type 2 diabetes mellitus (T2DM). Considering that obesity is an important associated levels, whether serum levels affected by body mass index (BMI)...
Stem cell-based therapy has great potential in regenerative medicine. However, the survival and engraftment rates of transplanted stem cells disease regions are poor limit effectiveness cell due to fragility cells. Here, an approach involving a single-cell coating surface-anchored nanogel regulate fate with anti-apoptosis capacity hypoxic ischemic environment infarcted hearts is developed for first time. A polysialic acid-based system used anchor microbial transglutaminase external surface...
Abstract Context The interaction of glycated hemoglobin A1c (HbA1c) and glycemic variability in relation to diabetes-related outcomes remains unknown. Objective To evaluate the relationship between HbA1c all-cause mortality across varying degrees patients with type 2 diabetes. Design, Setting, Patients This was a prospective study conducted single referral center. Data 6090 hospitalized diabetes analyzed. Glucose coefficient variation [coefficient (CV)] obtained as measure by using...
Previous studies suggest that the complexity of glucose time series may serve as a novel marker homeostasis.We aimed to investigate relationship between and all-cause mortality in patients with type 2 diabetes.Prospective data 6000 adult inpatients diabetes from single center were analyzed. The index (CGI) based on continuous monitoring (CGM) was measured at baseline refined composite multiscale entropy. Participants stratified by CGI tertiles of: < 2.15, 2.15 2.99, ≥ 3.00. Cox proportional...