A5100761805- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Pulmonary Hypertension Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Cancer-related Molecular Pathways
- Advanced Breast Cancer Therapies
- Cardiac Fibrosis and Remodeling
- Cancer, Lipids, and Metabolism
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Renal cell carcinoma treatment
- Extracellular vesicles in disease
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Coronary Interventions and Diagnostics
- Sirtuins and Resveratrol in Medicine
- Advanced Nanomaterials in Catalysis
- RNA regulation and disease
- CAR-T cell therapy research
- Influenza Virus Research Studies
- Genetic Associations and Epidemiology
- Cardiovascular Health and Disease Prevention
Indiana University – Purdue University Indianapolis
2024-2025
Soochow University
2022-2025
Union Hospital
2022-2025
Huazhong University of Science and Technology
2022-2025
Tongji Hospital
2025
University of Shanghai for Science and Technology
2025
Zhoukou Normal University
2025
Henan Agricultural University
2025
Hangzhou First People's Hospital
2015-2024
Indiana University School of Medicine
2024
Radiotherapy (RT) hinges on DNA damage-induced cancer cell death and the subsequent anti-tumor immunity. However, efficacy of RT is curtailed by cycle heterogeneity an immunosuppressive tumor microenvironment, which foster radioresistance. Here ion generator-based enhancement strategy demonstrated in a mouse model radioresistant tumor. The generator degraded resulting iron-triggered ferroptosis that enhanced immunogenic manganese-activated stimulator interferon gene reversed environment. As...
Abstract Oxidative stress is one of the mechanisms ageing‐associated vascular dysfunction. Angiotensin‐converting enzyme 2 (ACE2) and microRNA (miR)‐18a have shown to be down‐regulated in ageing cells. Our previous study has that ACE2‐primed endothelial progenitor cells (ACE2‐EPCs) protective effects on (ECs), which might due their released exosomes (EXs). Here, we aimed investigate whether ACE2‐EPC‐EXs could attenuate hypoxia/reoxygenation (H/R)‐induced injury ECs through carried miR‐18a....
Cancer cells demand amino acids beyond their usage as “building blocks” for protein synthesis. As a result, targeting acid acquisition and utilization has emerged pivotal strategy in cancer treatment. In the setting of leukemia therapy, compelling examples metabolism exist at both pre-clinical clinical stages. This review focuses on summarizing novel insights into glutamine, asparagine, arginine, tryptophan leukemias, providing comprehensive discussion perturbing to improve therapeutic...
Acute myocardial infarction (AMI) is a serious cardiovascular disease. Investigating new susceptibility genes for effective methods of early diagnosis AMI important. In the current study, peripheral blood miR-19a levels were detected by real-time polymerase chain reaction. Significant differences and logistic correlation analyses carried out grouping disease types stratification risk factors. Receiver-operator characteristic curve analysis was used to compare common clinical biochemical...
Vγ9Vδ2 T cell-based anticancer immunotherapy has shown some promise in early-phase clinical trials but there is still large room for improvement. Using the extracellular domain of human NKG2D, a stimulatory receptor expressed by cells, we constructed NKG2D ligand-specific chimeric antigen receptors (CARs). We adopted non-viral CAR approach via mRNA electroporation to modify cells and demonstrated that, upon interaction with ligand-positive cancer CARs substantially enhanced cytotoxic...
Abstract Objectives Baicalin, a natural flavone, has antithrombotic, antihyperlipidemic and antiinflammortory activity. It can also inhibit cancer cell proliferation reduce brain apoptosis. This study aimed to elucidate the effect of baicalin on excessive human pulmonary arterial smooth muscle cells (HPASMCs) induced by transforming growth factor-β1 (TGF-β1) investigate roles hypoxia inducible factor-1α (HIF-1α) aryl hydrocarbon receptor (AhR) in mediating this TGF-β1-induced HPASMCs....
Gamma delta (γδ) T cells and cytokine-induced killer (CIK) cells, which are a heterogeneous population of lymphocytes natural (NKT) have been separately expanded ex vivo shown to be capable targeting mediating cytotoxicity against various tumor in major histocompatibility complex-unrestricted manner. However, the co-expansion co-administration these immune not explored. In this study we describe an efficient method expand simultaneously both CIK Vγ9Vδ2 termed as CIKZ from human peripheral...
At present, GPX4's role in the occurrence and development of diffuse large B lymphoma (DLBCL) is rarely reported. This study's purpose to explore significance diagnosis, treatment, pathological mechanisms DLBCL. The TIMER 2.0, GEPIA, GEO databases were used analyze expression levels DLBCL tissue, peripheral blood, single cells, evaluate its potential performance as a therapeutic diagnostic marker. Cell experiments validate cells. And revealed mechanism action from three aspects: immunity,...
Coronary artery disease (CAD) is one of the most common diseases leading to mortality and morbidity worldwide. There considerable debate on whether serum transforming growth factor β1 (TGF-β1) levels are associated with long-term major adverse cardiovascular events in patients CAD, date, no study has specifically addressed different degrees CAD severity. Serum TGF-β1 mothers against decapentaplegic homolog 3 (SMAD3) concentrations were evaluated 279 268 controls without CAD. The clinical...
// Jie Cheng 1,2 , Meng-Yun Cai 1,3 Yu-Ning Chen Zhi-Cheng Li Sai-Sai Tang Xi-Li Yang 4 Can 5 Xinguang Liu 1,3,6 and Xing-dong Xiong 1 Institute of Aging Research, Guangdong Medical University, Dongguan, P.R.China 2 Department clinical laboratory, The Affiliated Hospital Zhanjiang, 3 Provincial Key Laboratory Molecular Diagnostics, Cardiovascular Disease, First People’s Foshan, 6 Biochemistry & Biology, Correspondence to: Xiong, email: Keywords : ANRIL; single nucleotide...
Pulmonary arterial hypertension (PAH) is characterized by endothelial dysfunction and structural remodeling of the pulmonary vasculature, mediated initially reduced oxygen availability in lungs. Hypoxia inducible factor (HIF), consisting functional subunit, HIF‑1α, constitutively expressed HIF‑1β, involved pathological processes associated with hypoxia. In current study, sequences cDNAs amino acids HIF were analyzed using online bioinformatics tools. To further evaluate whether accounts for...
Phosphodiesterase 4 (PDE4) serves as a crucial regulator of cyclic adenosine monophosphate (cAMP) signaling and has been identified significant therapeutic target for inflammatory metabolic disorders impacting the gastrointestinal (GI) tract liver. Although pan-PDE4 inhibitors hold promise, their clinical use constrained by dose-dependent adverse effects. Recent progress in development isoform-specific PDE4 inhibitors, such those selective PDE4B/D, alongside targeted delivery systems like...
Epstein-Barr virus-induced gene 3 (EBI3) is a member of the interleukin-12 (IL-12) family structural subunit and can form heterodimer with IL-27p28 IL-12p35 to build IL-27 IL-35, respectively. However, stimulates whereas IL-35 inhibits antitumor T cell responses. To date, little known about role EBI3 in tumor microenvironment. In this study, firstly we assessed EBI3, IL-27p28, IL-12p35, gp130, p-STAT3 expression clinicopathological parameters colorectal cancer (CRC) tissues; then evaluated...
SIRT1 exerts protective effects against endothelial cells dysfunction, inflammation and atherosclerosis, indicating an important role on myocardial infarction (MI) pathogenesis. Nonetheless, the of variants MI risk remain poorly understood. Here we aimed to investigate influence polymorphisms individual susceptibility MI. Genotyping three tagSNPs (rs7069102, rs3818292 rs4746720) in gene was performed a Chinese Han population, consisting 287 cases 654 control subjects. In logistic regression...
Plaque rupture is a critical concern due to its potential for severe outcomes such as cerebral infarction and myocardial infarction, underscoring the urgency of noninvasive early diagnosis. Magnetic resonance imaging (MRI) has gained prominence in plaque imaging, leveraging noninvasiveness, high spatial resolution, lack ionizing radiation. Ultrasmall iron oxides, when modified with polyethylene glycol, exhibit prolonged blood circulation passive targeting toward sites, rendering them...
Abstract Background CD2‐associated protein (CD2AP) is a podocyte‐associated gene and its reduced expression associated with the development of proteinuria glomerulosclerosis. However, few studies have focused on correlation between prognosis CD2AP in renal clear cell carcinoma (ccRCC). Therefore, we aimed to assess regulation prognostic value ccRCC. Methods Multiple databases were employed examine RT‐qPCR, Western Blot immunohistochemistry used validate different lines tissue samples....
Drug-side effect research is vital for understanding adverse reactions arising in complex multi-drug therapies. However, the scarcity of higher-order datasets that capture combinatorial effects multiple drugs severely limits progress this field. Existing resources such as TWOSIDES primarily focus on pairwise interactions. To fill critical gap, we introduce HODDI, first Higher-Order Drug-Drug Interaction Dataset, constructed from U.S. Food and Drug Administration (FDA) Adverse Event Reporting...