A5055239193- Pulmonary Hypertension Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Advancements in Solid Oxide Fuel Cells
- Phagocytosis and Immune Regulation
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Electrocatalysts for Energy Conversion
- Cardiac Fibrosis and Remodeling
- Immunotherapy and Immune Responses
- Circular RNAs in diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- CAR-T cell therapy research
- Electronic and Structural Properties of Oxides
- Crystallization and Solubility Studies
- Cold Atom Physics and Bose-Einstein Condensates
- X-ray Diffraction in Crystallography
- Iron-based superconductors research
- Fuel Cells and Related Materials
- Parkinson's Disease Mechanisms and Treatments
- Cardiovascular Function and Risk Factors
- Monoclonal and Polyclonal Antibodies Research
- 2D Materials and Applications
- Quantum and electron transport phenomena
- Mesenchymal stem cell research
- Autophagy in Disease and Therapy
Nanjing Medical University
2025
Shanxi Medical University
2025
Shaanxi Provincial People's Hospital
2025
Guangdong Medical College
2015-2024
Jilin University
2016-2024
Tibet University
2024
Xijing Hospital
2011-2023
University of Groningen
2015-2023
Air Force Medical University
2011-2023
Sun Yat-sen University
2009-2023
Abstract Background Dendritic cells (DCs) are central for the initiation and regulation of innate adaptive immunity in tumor microenvironment. As such, many kinds DC-targeted vaccines have been developed to improve cancer immunotherapy numerous clinical trials. Targeted delivery antigens adjuvants DCs vivo represents an important approach development DC vaccines. However, nonspecific activation systemic preparation optimal immunodominant still represent major challenges. Methods We loaded...
: The apoptosis of pulmonary artery endothelial cells (PAECs) is an important factor contributing to the development hypertension (PH), a serious cardio-pulmonary vascular disorder. Salidroside (SAL) bioactive compound derived from herb Rhodiola, but potential protective effects SAL on PAECs and underlying mechanisms remain elusive. objective this study was determine role in hypoxia-induced dissect mechanisms. Male Sprague-Dawley (SD) rats were subjected hypoxia (10% O2) for 4 weeks...
Sphingosine 1-phosphate (S1P) mediates multiple pathophysiological effects in the cardiovascular system. However, role of S1P signaling pathological cardiac remodeling following myocardial infarction (MI) remains controversial. In this study, we found that greatly increased post-MI, accompanied with a significant upregulation sphingosine kinase-1 (SphK1) and receptor 1 (S1PR1) expression. MI-operated mice, inhibition production by using PF543 (the SphK1 inhibitor) ameliorated dysfunction....
Abstract A new family of transition‐metal monosilicides (MSi, M = Ti, Mn, Fe, Ru, Ni, Pd, Co, and Rh) electrocatalysts with superior electrocatalytic performance hydrogen evolution is reported, based on the computational experimental results. It proposed that these MSi can be synthesized within several minutes by adopting arc‐melting method. The previously reported RuSi not only fabricated more readily but eventually explored 8 good reaction catalysts. Silicides then another promising as...
Previous studies have shown a close association between an altered immune system and Parkinson's disease (PD). Neuroinflammation inhibition may be effective measure to prevent PD. Recently, numerous reports highlighted the potential of hydroxy-carboxylic acid receptor 2 (HCA2) in inflammation-related diseases. Notably, role HCA2 neurodegenerative diseases is also becoming more widely known. However, its exact mechanism PD remain investigated. Nicotinic (NA) one crucial ligands HCA2,...
Acute myocardial infarction (AMI) is a serious cardiovascular disease. Investigating new susceptibility genes for effective methods of early diagnosis AMI important. In the current study, peripheral blood miR-19a levels were detected by real-time polymerase chain reaction. Significant differences and logistic correlation analyses carried out grouping disease types stratification risk factors. Receiver-operator characteristic curve analysis was used to compare common clinical biochemical...
Here, we report on a novel bispecific antibody-derivative, designated RTX-CD47, with unique capacity for CD20-directed inhibition of CD47-SIRPα "don't eat me" signaling. RTX-CD47 comprises CD20-targeting scFv antibody fragment derived from rituximab fused in tandem to CD47-blocking scFv. Single agent treatment triggered significant phagocytic removal CD20pos/CD47pos malignant B-cells, but not CD20neg/CD47pos cells, and required no pro-phagocytic FcR-mediated Importantly, synergistically...
The aryl hydrocarbon receptor (AhR) mediates the control of environmental toxicity and modulates development pathogenesis cardiovascular system. However, little is known about role AhR in coronary arterial disease (CAD) susceptibility. We therefore conducted a case-control study Chinese population assessed potential association between variants CAD Compared with controls, circulating expression was found to be significantly increased patients its subtypes including ST-segment non-ST-segment...
Layered transition-metal dichalcogenides based on VIB elements have attracted substantial attention for their applications in energy storage and conversion.
The effects of sublethal concentrations 0.1, 0.5, and 1.2 µg mL−1 the chitin synthesis inhibitor, hexaflumuron, on larval growth development, count proportion hemocytes, carbohydrate content (trehalose glyceride) in hemolymph were investigated cutworm, Spodoptera litura (Fabricious) (Lepidoptera: Noctuidae). When 3rd instar larvae subjected to concentrations, there dose–dependent weight length each larvae, percent pupation duration development. Most died during molting process at all...
Abstract Objectives Baicalin, a natural flavone, has antithrombotic, antihyperlipidemic and antiinflammortory activity. It can also inhibit cancer cell proliferation reduce brain apoptosis. This study aimed to elucidate the effect of baicalin on excessive human pulmonary arterial smooth muscle cells (HPASMCs) induced by transforming growth factor-β1 (TGF-β1) investigate roles hypoxia inducible factor-1α (HIF-1α) aryl hydrocarbon receptor (AhR) in mediating this TGF-β1-induced HPASMCs....
Antibodies that block PD-L1/PD-1 immune checkpoints restore the activity of functionally-impaired antitumor T cells. These antibodies show unprecedented clinical benefit in various advanced cancers, particularly melanoma. However, only a subset cancer patients responds to current PD-L1/PD-1-blocking strategies, highlighting need for further advancements PD-L1/PD-1-based immunotherapy. Here, we report on novel approach designed combine PD-L1 checkpoint inhibition with tumor-selective...
Addition of rituximab (R) to "CHOP" (cyclophosphamide, doxorubicin, vincristine, and prednisone) chemotherapy improved outcome for diffuse large B-cell lymphoma (DLBCL) patients. Approximately 40% patients who receive R-CHOP still succumb disease due intrinsic resistance or relapse. A potential negative regulator DLBCL treatment is the CD47 "don't eat me" immune checkpoint. To delineate impact CD47, we used a clinically molecularly well-annotated cohort 939 patients, comprising both germinal...
Abstract Background Anti-angiogenic therapy has been widely applied to the clinical treatment of malignant tumors. However, efficacy such treatments called into question, especially in triple-negative breast cancer (TNBC). Bevacizumab, first anti-angiogenic agent approved by FDA, actually increases invasive and metastatic properties TNBC cells, resulting from activation Wnt/β-catenin signaling response hypoxia. As a critical receptor signaling, Frizzled-7 (Fzd7) is aberrantly expressed TNBC,...
Oxygen permeation, stability and chemical bonding characteristics of 40 wt% Nd<sub>0.6</sub>Sr<sub>0.4</sub>CoO<sub>3−δ</sub>–60 Ce<sub>0.9</sub>Nd<sub>0.1</sub>O<sub>2−δ</sub>(40NSCO–60CNO) dual-phase composite membrane reactors were investigated.