A5103137716- Lymphoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Vascular Tumors and Angiosarcomas
- CAR-T cell therapy research
- Renal cell carcinoma treatment
- Galectins and Cancer Biology
- Neurobiology and Insect Physiology Research
- T-cell and B-cell Immunology
- Oral and Maxillofacial Pathology
- Immunodeficiency and Autoimmune Disorders
- Salivary Gland Tumors Diagnosis and Treatment
- Renal and related cancers
- Invertebrate Immune Response Mechanisms
- Sarcoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Cutaneous lymphoproliferative disorders research
- Insect symbiosis and bacterial influences
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Neuroblastoma Research and Treatments
- Drug Transport and Resistance Mechanisms
- Ferroptosis and cancer prognosis
North Sichuan Medical University
2024
Affiliated Hospital of North Sichuan Medical College
2023-2024
West China Hospital of Sichuan University
2021-2023
Sichuan University
2021-2023
Nanchang University
2022
First Affiliated Hospital of Nanchang University
2022
East China University of Science and Technology
2012
Chinese University of Hong Kong
1999-2001
Sun Yat-sen University
2001
University of Hong Kong
1999
Abstract Background Overexpression of T-cell immunoglobulin and mucin domain-containing protein 3 (TIM3) is related to the exhaustion CD8 + tumor-infiltrating lymphocytes (TILs) in diffuse large B-cell lymphoma (DLBCL). However, mechanism TIM3-mediated TILs DLBCL remains poorly understood. Therefore, we aimed clarify potential pathway involved its significance DLBCL. Methods The expression TIM3 correlation with exhaustion, key ligand TIM3, were analyzed using single-cell RNA sequencing...
The effects of sublethal concentrations 0.1, 0.5, and 1.2 µg mL−1 the chitin synthesis inhibitor, hexaflumuron, on larval growth development, count proportion hemocytes, carbohydrate content (trehalose glyceride) in hemolymph were investigated cutworm, Spodoptera litura (Fabricious) (Lepidoptera: Noctuidae). When 3rd instar larvae subjected to concentrations, there dose–dependent weight length each larvae, percent pupation duration development. Most died during molting process at all...
Exhaustion of CD8+ tumor-infiltrating lymphocytes (TILs), characterized by the overexpression immune checkpoints (IC), is a major impediment to anti-tumor immunity. However, exhaustion status CD8+TILs in angioimmunoblastic T cell lymphoma (AITL) remains unclear. Therefore, we aimed elucidate AITL and its influence on prognosis.The correlation between IC expression was analyzed using single-cell RNA sequencing (n = 2), flow cytometry 20), 20). Biological changes related at different cytotoxic...
Background Angioimmunoblastic T-cell lymphoma (AITL) has a rich tumor microenvironment (TME) that typically harbors plenty of CD4+tumor infiltrating lymphocytes, (TIL)-T-cells (so called common AITL). Nonetheless, AITL with large numbers CD8+TIL-Ts outnumber CD4+cells have been observed (CD8-predominant However, detailed comparison CD8-predominant and are still lacking. Methods We compared clinicopathological features, TIL subsets, TME T cell receptor-β (TRB), immunoglobulin heavy chain...
Keywords extranodal natural killer (NK)/T-cell lymphoma (ENKTL), chronic lymphocytic leukemia (CLL), composite Lymphoma
<title>Abstract</title> Background RNASET2 has been identified as an oncogene with anti-angiogenic and immunomodulatory effects in a variety of cancers, but its function clear cell renal carcinoma (ccRCC) remains unknown. Methods The expression matrix was extracted from the Tumor Genome Atlas (TCGA) Gene Expression Omnibus (GEO) datasets analysed for diagnostic prognostic value. mRNA detected by quantitative polymerase chain reaction (qPCR) ccRCC patients cancer lines. Wound healing assay,...