A5052254377- Phagocytosis and Immune Regulation
- Immunotherapy and Immune Responses
- Glycosylation and Glycoproteins Research
- Erythrocyte Function and Pathophysiology
- CAR-T cell therapy research
- Cell Adhesion Molecules Research
- Immune Cell Function and Interaction
- Immune cells in cancer
- Monoclonal and Polyclonal Antibodies Research
- RNA Interference and Gene Delivery
University Medical Center Groningen
2017
University of Groningen
2017
Here, we report on a novel bispecific antibody-derivative, designated RTX-CD47, with unique capacity for CD20-directed inhibition of CD47-SIRPα "don't eat me" signaling. RTX-CD47 comprises CD20-targeting scFv antibody fragment derived from rituximab fused in tandem to CD47-blocking scFv. Single agent treatment triggered significant phagocytic removal CD20pos/CD47pos malignant B-cells, but not CD20neg/CD47pos cells, and required no pro-phagocytic FcR-mediated Importantly, synergistically...
TNFR superfamily (TNFRSF) members have important immunoregulatory functions and are of clear interest for cancer immunotherapy. Various TNFRSF agonists been clinically evaluated, but met with limited efficacy and/or toxicity. Recent insights indicate that 'first-generation' lack as they do not effectively cross-link their corresponding receptor. Reversely, ubiquitous receptor(s) cross-linking by CD40 Fas agonistic antibodies resulted in dose-limiting liver To overcome these issues, we...