A5073358520- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Ion channel regulation and function
- Cardiac Fibrosis and Remodeling
- Cardiac pacing and defibrillation studies
- Heart Rate Variability and Autonomic Control
- Cardiac Ischemia and Reperfusion
- Neuroscience and Neural Engineering
- Cardiovascular Function and Risk Factors
- Congenital heart defects research
- Receptor Mechanisms and Signaling
- Cardiomyopathy and Myosin Studies
- Tissue Engineering and Regenerative Medicine
- Atherosclerosis and Cardiovascular Diseases
- Signaling Pathways in Disease
- Cardiac Imaging and Diagnostics
- Vagus Nerve Stimulation Research
- Nicotinic Acetylcholine Receptors Study
- Cardiac Arrest and Resuscitation
- Connexins and lens biology
- COVID-19 Clinical Research Studies
- Cardiovascular Syncope and Autonomic Disorders
- Heat shock proteins research
- Blood Pressure and Hypertension Studies
Wuhan University
2015-2024
Renmin Hospital of Wuhan University
2015-2024
National Taiwan University
2024
National Yang Ming Chiao Tung University
2024
The First Affiliated Hospital, Sun Yat-sen University
2024
Zhongshan Hospital
2024
Fudan University
2024
Sun Yat-sen University
2024
East China Jiaotong University
2022-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2006-2022
<h3>Importance</h3> Coronavirus disease 2019 (COVID-19) has resulted in considerable morbidity and mortality worldwide since December 2019. However, information on cardiac injury patients affected by COVID-19 is limited. <h3>Objective</h3> To explore the association between with COVID-19. <h3>Design, Setting, Participants</h3> This cohort study was conducted from January 20, 2020, to February 10, a single center at Renmin Hospital of Wuhan University, Wuhan, China; final date follow-up 15,...
Abstract Aims To investigate the characteristics and clinical significance of myocardial injury in patients with severe coronavirus disease 2019 (COVID-19). Methods results We enrolled 671 eligible hospitalized COVID-19 from 1 January to 23 February 2020, a median age 63 years. Clinical, laboratory, treatment data were collected compared between who died survivors. Risk factors death analysed using multivariable regression models. A total 62 (9.2%) died, more often had (75.8% vs. 9.7%; P...
Atrial fibrillation (AF) is the most common persistent cardiac arrhythmia. This study aimed to estimate its prevalence and explore associated factors in adults aged 18 years or older China.Study data were derived from a national sample July 2020 September 2021. Participants recruited using multistage stratified sampling method twenty-two provinces, autonomous regions, municipalities China. AF was determined based on history of diagnosed electrocardiogram results.A total 114,039 respondents...
Melatonin confers cardioprotective effects on multiple cardiovascular diseases, including doxorubicin-induced cardiomyopathy. The effectiveness of melatonin in mitigating myocardial injuries caused by Doxorubicin through enhancement mitochondrial function is already established, however, the role regulating Sirtuin-1 (Sirt1)/Nuclear factor E2-associated 2 (Nrf2) pathway lessening onset Doxorubicin-induced cardiomyopathy yet to be elucidated. To address this, H9C2 cardiomyocytes and C57BL/6...
Previous studies indicate resveratrol pretreatment can protect cardiomyocytes. However, it is largely unknown whether protects cardiomyocytes when applied at reperfusion. The purpose of this study was to investigate given reoxygenation could under the anoxia/reoxygenation (A/R) condition and examine underlying mechanism. In study, primary cultures neonatal rat were randomly distributed into three groups: control group, A/R group (cultured subjected 3 h anoxia followed by 2 reoxygenation),...
Malignant ventricular arrhythmia (VA) is a major contributor to sudden cardiac death (SCD) in patients with pulmonary arterial hypertension (PAH)-induced right heart failure (RHF). Recently, dapagliflozin (DAPA), sodium/glucose cotransporter-2 inhibitor (SGLT2i), has been found exhibit cardioprotective effects left systolic dysfunction. In this study, we examined the of DAPA on VA vulnerability rat model PAH-induced RHF.Rats randomly received monocrotaline (MCT, 60 mg/kg) or vehicle via...
Myocardial infarction (MI) and the subsequent heart failure remain one of leading causes morbidity mortality world wide. A number studies have demonstrated that bioderived materials improve cardiac function after implantation because their angiogenic potential. In this study, we hypothesized injection biomaterials into infarcted myocardium can preserve left ventricular (LV) through its prevention paradoxical systolic bulging. To test hypothesis, was induced in rabbit by coronary artery...
We have previously demonstrated that catheter-based renal sympathetic denervation (RSD) could suppress atrial fibrillation (AF) in canines with short-time rapid right pacing (RAP). However, the role of on remodeling is unclear. The aim present study was to explore long-term effect RSD during prolonged RAP. Twenty mongrel dogs were implanted a high-frequency cardiac pacemaker transvenous lead inserted into appendage. divided three groups: sham-operated group (n = 6), chronic RAP (CRAP) 7),...
Atrial fibrillation (AF) alters atrial cardiomyocyte (ACM) Ca2+ handling, promoting ectopic beat formation. We examined the effects of AF-associated remodeling on Ca2+-related action potential dynamics and consequences for AF susceptibility. was maintained electrically in dogs by right (RA) tachypacing. ACMs isolated from showed increased release refractoriness, spontaneous spark frequency, cycle length (CL) threshold duration (APD) alternans versus controls. situ CL Ca2+/APD spatial...
Abstract Background Metabolic syndrome (MetS) is characterized by a cluster of signs metabolic disturbance and has caused huge burden on the health system. The study aims to explore prevalence characteristics MetS defined different criteria in Chinese population. Methods Using data China Hypertension Survey (CHS), nationally representative cross-sectional from October 2012 December 2015, total 28,717 participants aged 35 years above were included analysis. definitions International Diabetes...
Abstract Background and Aims Despite advances in technology techniques, the recurrence rate of persistent atrial fibrillation (AF) following catheter ablation remains high. The Shensong Yangxin (SSYX) capsule, a renowned traditional Chinese medicine formula, is used treatment cardiac arrhythmias. This trial aimed to investigate whether SSYX can improve clinical outcomes patients who have undergone for AF. Methods A multi-centre, randomized, double-blind, placebo-controlled was conducted at...
Objectives: To observe levels of matrix metalloproteinase (MMP)-9 and evaluate their significance in various stages idiopathic atrial fibrillation (AF). Methods: Patients with AF were recruited into this prospective study classified one three groups according to stage disease progression: paroxysmal AF; persistent permanent AF. Healthy individuals enrolled as control subjects. Serum MMP-9 all four determined using a double-antibody sandwich enzyme-linked immunosorbent assay. Results: Each...
ABSTRACT Cardiac hypertrophy is the response of heart to a variety hypertrophic stimuli; this condition progresses failure and sudden death. MicroRNAs (miRs) are family small, non‐coding RNAs that mediate posttranscriptional gene silencing. Recent studies have identified miRs as important regulators in cardiac hypertrophy. One specific miR, miR‐150 has been reported be downregulated murine hearts. However, role regulator remains unclear. In present study, we used gain‐of‐function...
Caspase-1 activation senses metabolic danger-associated molecular patterns (DAMPs) and mediates the initiation of inflammation in endothelial cells. Here, we examined whether caspase-1 pathway is responsible for sensing hyperlipidemia as a DAMP bone marrow (BM)-derived Stem cell antigen-1 positive (Sca-(1+)) stem/progenitor cells weakening their angiogenic ability. Using biochemical methods, gene knockout, therapy myocardial infarction (MI) models, had following findings: 1) Hyperlipidemia...
Cardiotoxicity linked to doxorubicin (DOX) is primarily caused by inflammation, oxidative stress, and apoptosis. The role of tubeimoside I (TBM) in DOX-induced cardiotoxicity remains ambiguous, despite growing evidence that it could reduce apoptosis various diseases. This study was designed investigate the TBM uncover underlying mechanisms. H9c2 cell line C57BL/6 mice were used construct an vitro vivo model myocardial injury, respectively. We observed DOX treatment provoked cardiomyocyte...