A5100364005- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Circular RNAs in diseases
- Peroxisome Proliferator-Activated Receptors
- Immune Response and Inflammation
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer, Lipids, and Metabolism
- RNA Research and Splicing
- Cardiac Fibrosis and Remodeling
- Microbial infections and disease research
- RNA modifications and cancer
- Liver Disease Diagnosis and Treatment
- Proteoglycans and glycosaminoglycans research
- Cardiac Ischemia and Reperfusion
- Heme Oxygenase-1 and Carbon Monoxide
- Genomics, phytochemicals, and oxidative stress
- Pharmacogenetics and Drug Metabolism
- Ubiquitin and proteasome pathways
- Calpain Protease Function and Regulation
- Glycosylation and Glycoproteins Research
- Cancer-related Molecular Pathways
- Fibroblast Growth Factor Research
- Cholesterol and Lipid Metabolism
- Receptor Mechanisms and Signaling
Wuhan University
2012-2025
Renmin Hospital of Wuhan University
2012-2025
Soochow University
2007-2025
Changchun University
2025
Zhongnan Hospital of Wuhan University
2025
Chongqing Medical University
2011-2025
Chinese PLA General Hospital
2008-2025
China International Science and Technology Cooperation
2025
Children's Hospital of Chongqing Medical University
2025
Zhejiang University
2025
MicroRNA-26a (miR-26a) is a tumor suppressor that reduced in hepatocellular carcinoma (HCC). Increasing evidence indicates the liver hormone-responsive organ like breast. The purpose of this study was to investigate whether miR-26a, regulated by human α-fetoprotein (hAFP) and telomerase reverse transcriptase (hTERT) dual promoter, could be specifically expressed cells suppress their growth clarify estrogen receptor-α (ERα) miR-26a involved HCC process. Our data show expression driven...
Abstract Sulforaphane (SFN) is a kind of natural isothiocyanate, which exists in cruciferous plants. Only few studies were about the anti-inflammatory effects sulforaphane ulcerative colitis. In this study, our purpose to explore on intestinal microbial community UC mice. The severity mice colitis measured by colon length, survial rate, body weight and disease activity index (DAI) score. Histological morphological evaluation tissues performed HE. 16S rRNA gene amplicon pyrosequencing was...
We have reported that normal human salivary gland-derived epithelial cells exclusively express keratinocyte growth factor receptor (KGFR). In the process of malignant transformation gland tumors, KGFR gene expression disappeared concomitantly with de novo fibroblast 1 (FGFR1) and FGFR4 genes. present study, we introduced wild-type cDNA or chimeric KGFR/FGFR1 cDNA, which encoded extracellular domain intracellular FGFR1, into HSY adenocarcinoma cell line. The tyrosine kinase suppressed...
ABSTRACT Cardiac hypertrophy is the response of heart to a variety hypertrophic stimuli; this condition progresses failure and sudden death. MicroRNAs (miRs) are family small, non‐coding RNAs that mediate posttranscriptional gene silencing. Recent studies have identified miRs as important regulators in cardiac hypertrophy. One specific miR, miR‐150 has been reported be downregulated murine hearts. However, role regulator remains unclear. In present study, we used gain‐of‐function...
Abstract BACKGROUND The intestinal microbiota has a wide variety of functions in the host. A positive effect plant extract on animals been reported. However, orange essential oil and its components limonene, linalool citral microflora mice seldom effects intragastric administration biochemical indexes were studied. RESULTS oil, immune organ index (spleen thymus index), IgM IL‐2 was not significant ( P > 0.05). increase < 0.05) H + K ‐ATPase activity, IgA, IgG, limonene group observed...
Heme oxygenase-1 (HO-1) is a stress-inducible enzyme with diverse cytoprotective effects, and reported to have an important role in angiogenesis recently. Here we investigated whether HO-1 transduced by mesenchymal stem cells (MSCs) can induce angiogenic effects infarcted myocardium. was transfected into cultured MSCs using adenoviral vector. 1 × 106 Ad-HO-1-transfected (HO-1-MSCs) or Ad-Null-transfected (Null-MSCs) PBS respectively injected rat hearts intramyocardially at h post-myocardial...
The present study aimed to assess the effect of sigma-1 receptor (S1R) stimulation on autonomic nerve dysfunction and susceptibility atrial fibrillation (AF) in a rat depression model. Male rats were randomly divided into one following four treatment groups: saline [control (CTL)]; + intragastric administration SA4503, an agonist S1R (CTS); chronic unpredictable mild stress (CUMS) produce (MDD); CUMS SA4503 (MDS). Depression-like behaviors, such as reduced sucrose preference, decreased body...
Background Epidermal growth factor (EGF), latrophilin and seven transmembrane domain-containing protein 1 (ELTD1) is developmentally upregulated in the heart. Little known about relationship between ELTD1 cardiac diseases. Therefore, we aimed to clarify role of pressure overload–induced hypertrophy. Methods Results C57BL/6J wild-type (WT) mice ELTD1-knockout (KO) were subjected left ventricular overload by descending aortic banding (AB). KO exhibited more unfavorable remodeling than WT 28...
Background/Aims: Iodine may trigger tumorigenesis and development of thyroid carcinoma, but the mechanisms involved remained elusive. MicroRNA (MiRNAs) are known to be in each stage cancer development; however, role miRNAs iodine-induced carcinoma unknown. In this study, we aimed at investigating miRNA related signaling pathway cells. Methods: Levels mRNAs were determined using RT-qPCR proteins quantified by western blotting. Cell migration proliferation checked Transwell assay CCK8...
Although knowledge regarding the pathogenesis of nonalcoholic fatty liver disease (NAFLD) has profoundly grown in recent decades, internal restrictive mechanisms remain largely unknown. We have recently reported that transcription repressor interferon regulatory factor-2 binding protein 2 (IRF2BP2) is enriched cardiomyocytes and inhibits pathological cardiac hypertrophy mice. Notably, IRF2BP2 abundantly expressed hepatocytes dramatically down-regulated steatotic livers, whereas role NAFLD...
Proper activation of Toll-like receptor (TLR)-mediated signaling and production proinflammatory cytokines are critical for the initiation innate immunity, while specific mechanism maintaining inflammatory homeostasis remains mostly unknown. Here, we show that Ets2 is upregulated following LPS VSV stimulation. knockdown or knockout leads to increased IL-6, TNF-α, IFN-β in macrophages. Consistently, Ets2-deficient mice exacerbated cytokine more susceptible CLP-induced sepsis. Mechanistically,...
Background and Aims Although the prevalence of NAFLD has risen dramatically to 25% adult population worldwide, there are as yet no approved pharmacological interventions for disease because uncertainty about underlying molecular mechanisms. It is known that mitochondrial dysfunction an important factor in development NAFLD. Mitochondrial antiviral signaling protein (MAVS) a critical adaptor host defenses against viral infection. However, role MAVS metabolism during progression remains...
ABSTRACT Glioblastoma (GBM) is the most common malignant primary brain tumor, with a mean survival of less than 2 years. Unique structures and microenvironment, including blood−brain barriers, put great challenges on clinical drug development. Sophoricoside (Sop), an isoflavone glycoside isolated from seeds Sophora japonica L., one active constituents traditional Chinese medicine found to inhibit bioactivity cytokines (e.g., interleukin‐5) inflammatory responses, as well attenuate glucose...
Colorectal cancer with chromosomal instability (CIN+) phenotype is immunosuppressive and refractory to immune checkpoint blockade (ICB) therapy. Recently, KIF18A found be a mitotic vulnerability in chromosomally unstable cancers, but whether targeting affects antitumor immunity CIN+ colorectal unknown. In our study, western blot, cell viability assay, transwell migration invasion assays, flow cytometry, animal model, immunohistochemistry (IHC) staining, reverse transcription-quantitative PCR...