A5100397426- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Mitochondrial Function and Pathology
- Cancer-related molecular mechanisms research
- Microtubule and mitosis dynamics
- RNA Interference and Gene Delivery
- Cancer, Lipids, and Metabolism
- Dendrimers and Hyperbranched Polymers
- Immune Response and Inflammation
- Proteoglycans and glycosaminoglycans research
- Histone Deacetylase Inhibitors Research
- Cancer-related gene regulation
- Glycosylation and Glycoproteins Research
- Cardiac Imaging and Diagnostics
- Immunotherapy and Immune Responses
- Advanced MRI Techniques and Applications
- Genetic and Kidney Cyst Diseases
- Endoplasmic Reticulum Stress and Disease
- Cell death mechanisms and regulation
- Trace Elements in Health
- Autophagy in Disease and Therapy
- Ubiquitin and proteasome pathways
- Radiomics and Machine Learning in Medical Imaging
Shaanxi Normal University
2023-2025
Huazhong University of Science and Technology
2011-2025
First Affiliated Hospital of Zhengzhou University
2016-2025
Wenzhou Medical University
2020-2025
Sichuan University
2011-2025
Shanxi Medical University
2021-2025
Affiliated Hospital of Jiangsu University
2025
Henan Agricultural University
2025
United Imaging Healthcare (China)
2021-2025
Xiangyang Central Hospital
2025
Solid-state polymer light-emitting electrochemical cells have been fabricated using thin films of blends poly(1,4-phenylenevinylene) and poly(ethylene oxide) complexed with lithium trifluoromethanesulfonate. The contain three layers: the film (as emissive layer) indium−tin oxide aluminum as two contact electrodes. When externally biased, conjugated polymers are p-doped n-doped on opposite sides layer, a p−n junction is formed in between. admixed electrolyte provides counterions ionic...
Abstract Antimicrobial peptides (AMPs) have recently attracted a great deal of attention as promising antibiotic candidates, but some obstacles such toxicity and high synthesis cost must be addressed before developing them further. For short with improved cell selectivity, we designed series modified PMAP-36 analogues. assays showed that decreasing chain length in certain range retained the antimicrobial activity parental peptide reduced hemolysis. The 18-mer RI18 exhibited excellent against...
Breast cancer (BC) is one of the major public health challenges worldwide. Studies that address new evidence on trends BC are great importance for preventing and controlling occurrence development diseases improving health. The aim this study was to analyze outcomes global burden disease (GBD), incidence, deaths, risk factors from 1990 2019, predict GBD until 2050 inform control planning efforts. In study, results show regions with low levels socio-demographic index (SDI) will have largest...
Abstract Tumor‐associated macrophages (TAMs) play an essential role in tumor progression, metastasis, and antitumor immunity. Ferroptosis has attracted extensive attention for its lethal effect on cells, but the of ferroptosis TAMs impact progression have not been clearly defined. Using transgenic mouse models, this study determines that xCT‐specific knockout is sufficient to limit tumorigenicity metastasis HCC achieved by reducing TAM recruitment infiltration, inhibiting M2‐type...
Diabetic nephropathy (DN) is thought to be the major cause of end-stage renal disease. Due its complicated pathogenesis and low efficacy DN treatment, a deep understanding new etiological factors may useful. Ferroptosis, nonapoptotic form cell death, characterized by accumulation iron-dependent lipid peroxides lethal levels. Ferroptosis-triggered tubular injury reported participate in development DN, blocking ferroptosis might an effective strategy prevent DN. Quercetin (QCT), natural...
Abstract Cardiac aging, particularly cardiac cell senescence, is a natural process that occurs as we age. Heart function gradually declines in old age, leading to continuous heart failure, even people without prior history of disease. To address this issue and improve function, it crucial investigate the molecular mechanisms underlying senescence. This review summarizes main key proteins involved further discusses modulators cellular senescence aging hearts. Furthermore, discussion will...
When shed from the cell surface, heparan sulfate proteoglycan syndecan-1 can facilitate growth, angiogenesis, and metastasis of tumors. Here we report that tumor expression heparanase, an enzyme known to be a potent promoter progression metastasis, regulates both level location within microenvironment by enhancing its synthesis subsequent shedding surface. Heparanase regulation is detected in human myeloma breast cancer lines. This requires presence active enzyme, because mutated forms...
High levels of heparanase are an indicator poor prognosis in myeloma patients, and up-regulation the enzyme enhances tumor growth, angiogenesis, metastasis animal models. At least part impact driving aggressive phenotype is due to its effect on increasing expression shedding heparan sulfate proteoglycan syndecan-1, a molecule known promote progression. The present work demonstrated that elevation cells stimulates sustained ERK phosphorylation turn drives MMP-9 expression. In addition,...
Peptide dendrimers have shown promise as an attractive platform for drug delivery. In this study, mPEGylated peptide dendrimer–doxorubicin (dendrimer–DOX) conjugate‐based nanoparticle is prepared and characterized enzyme‐responsive delivery vehicle. The DOX conjugated to the periphery of dendrimer via tetra‐peptide linker Gly‐Phe‐Leu‐Gly (GFLG). dendrimer–DOX conjugate can self‐assemble into nanoparticle, which confirmed by dynamic light scattering, scanning electron microscopy, transmission...
The barrier functions of the stratum corneum and epidermal layers present a tremendous challenge in achieving effective transdermal delivery drug molecules. Although few reports have shown that poly(amidoamine) (PAMAM) dendrimers are skin-penetration enhancers, little is known regarding fundamental mechanisms behind dendrimer-skin interactions. In this Article, we performed systematic study to better elucidate how interact with skin depending on their size surface groups. Franz diffusion...
Hyperglycolysis, observed within the penumbra zone during brain ischemia, was shown to be detrimental for tissue survival because of lactate accumulation and reactive oxygen species overproduction in clinical experimental settings. Recently, mounting evidence suggests that glycolytic reprogramming induced metabolic enzymes can fuel activation peripheral immune cells. However, possible roles details regarding hyperglycolysis neuroinflammation ischemia are relatively poorly understood. Here,...
Zinc methionine (ZnMet), zinc lysine (ZnLys), glycine (ZnGly) and sulfate (ZnSO4 · H2O) were evaluated as dietary sources for Litopenaeus vannamei. Three Zn–amino acid complexes with a molar amino to Zn ratio of 2:1 compared using casein-based purified diet. Five groups four replicates shrimps (mean weight 0.72 ± 0.02 g) given basal diet either unsupplemented (control) or supplemented 30 mg kg− 1 the organic respectively, 12 weeks. Results showed that source affects shrimp growth, survival...
BackgroundIdentifying effective drugs to suppress vascular inflammation is a promising strategy delay the progression of abdominal aortic aneurysm (AAA). Itaconate has vital role in regulating inflammatory activation various diseases. However, itaconate AAA unknown. In this study, we explored inhibitory effect on formation and its underlying mechanisms.MethodsQuantitative PCR, western blotting immunohistochemistry were used determine Irg1 downstream Nrf2 expression human mouse samples....
Nutritional regulation of endogenous antimicrobial peptide (AMP) expression is considered a promising nonantibiotic approach to suppressing intestinal infection pathogen. The current study investigated the effects l-arginine on LPS-induced inflammation and barrier dysfunction in vivo vitro. results revealed that attenuated inflammatory response, inhibited downregulation tight junction proteins (TJP) (p < 0.05) by LPS, maintained integrity. In porcine epithelial cells (IPEC-J2), obviously...