A5073180479- Multiple Myeloma Research and Treatments
- Scoliosis diagnosis and treatment
- Protein Degradation and Inhibitors
- Genomic variations and chromosomal abnormalities
- Bone fractures and treatments
- Spinal Fractures and Fixation Techniques
- Hip disorders and treatments
- Chromosomal and Genetic Variations
- Hip and Femur Fractures
- Cancer Genomics and Diagnostics
- Glycosylation and Glycoproteins Research
- Acute Myeloid Leukemia Research
- Chronic Lymphocytic Leukemia Research
- Shoulder Injury and Treatment
- Bone Tumor Diagnosis and Treatments
- Musculoskeletal Disorders and Rehabilitation
- Glioma Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Orthopedic Surgery and Rehabilitation
- Injury Epidemiology and Prevention
- Diversity and Career in Medicine
- Cardiac, Anesthesia and Surgical Outcomes
- Spine and Intervertebral Disc Pathology
- Trauma and Emergency Care Studies
- Elbow and Forearm Trauma Treatment
Le Bonheur Children's Hospital
2014-2024
Campbell Clinic
2015-2024
University of Tennessee at Knoxville
2015-2024
University of Arkansas for Medical Sciences
2013-2024
University of Tennessee Health Science Center
2009-2024
Gillette Children's Specialty Healthcare
2024
Stryker (United States)
2024
Medtronic (United States)
2024
NuVasive (United States)
2024
Winthrop Rockefeller Foundation
2020-2023
Magnetic resonance imaging (MRI) permits the detection of diffuse and focal bone marrow infiltration in absence osteopenia or osteolysis on standard metastatic surveys (MBSs).Both baseline MBS MRI were available 611 668 myeloma patients who treated uniformly with a tandem autologous transplantation-based protocol evaluated to determine their respective merits for disease staging, response assessment, outcome prediction.MRI detected lesions (FLs) 74% 56% imaged anatomic sites; 52% 267 normal...
Fractures in children are an important public health issue and a frequent cause of emergency room visits. The purpose this descriptive epidemiological study was to identify the most pediatric fractures per 1000 population at risk United States using 2010 National Electronic Injury Surveillance System (NEISS) database US Census information.The NEISS queried for all between ages 0 19 years. national estimates were compared with data extrapolate occurrence rates.The annual increased from 14,...
When shed from the cell surface, heparan sulfate proteoglycan syndecan-1 can facilitate growth, angiogenesis, and metastasis of tumors. Here we report that tumor expression heparanase, an enzyme known to be a potent promoter progression metastasis, regulates both level location within microenvironment by enhancing its synthesis subsequent shedding surface. Heparanase regulation is detected in human myeloma breast cancer lines. This requires presence active enzyme, because mutated forms...
Object. The malignant progression of benign tumors is well documented in gliomas and other systemic lesions. It also known that some meningiomas become progressively aggressive despite their original status. theory clonal evolution widely believed to explain meningioma; however, the data used stepwise have typically been derived from cytogenetic analysis different types grades patients. In this study, authors examined obtained a group patients with showed clear histopathological toward...
The preponderance of progesterone receptors (PRs) and the scarcity estrogen (ERs) in meningiomas are well known. expression PRs may relate to tumor grade recurrence. Cytogenetic abnormalities associated with aggressive behavior, recurrence, progression. In this study, authors focus on prognostic implications hormone help determine clinical biological aggressiveness tumors their correlations cytogenetic abnormalities.Two hundred thirty-nine patients were separated into three groups. Group 1...
Radiation-induced meningiomas are known to occur after high- and low-dose cranial radiation therapy. The goal of this study was discern the distinguishing findings characteristics radiation-induced meningiomas.The records 16 patients (seven men nine women) who fulfilled criteria for were retrospectively reviewed. Clinical, histopathological, cytokinetic, cytogenetic as well patients' outcome analyzed. mean age 38.8 years tumor latency 26.5 years. Five had multiple in irradiated field....
PURPOSE Although important predictors of survival in myeloma patients have been identified, it is well recognized that better prognostic factors for this disease are needed. Because cytogenetics play a dominant role the outcome with acute leukemia, their value was evaluated large group newly diagnosed and previously treated receiving autotransplants. METHODS A total 427 either (26%) or (74%) received tandem transplants, supported by mobilized peripheral-blood stem cells. Numerous variables,...
Integrative multiomics analysis of myeloma identifies 12 disease subtypes defined by specific patterns genetic alterations.
Myelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML) have been reported after autologous transplantation (AT) for lymphoma. It is not clear whether myeloablative therapy used in conjunction with contributes to the development of MDS/AML or conventional chemotherapy preceding transplant, administered over a prolonged period, causes these secondary malignancies. To address this issue, we examined 188 patients multiple myeloma (MM) who had received AT. 71 no more than one cycle...