A5100317518- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- Dendrimers and Hyperbranched Polymers
- Advanced Biosensing Techniques and Applications
- Nanoparticles: synthesis and applications
- Nanoparticle-Based Drug Delivery
- Quantum Dots Synthesis And Properties
- MicroRNA in disease regulation
- Nanoplatforms for cancer theranostics
- Monoclonal and Polyclonal Antibodies Research
- Cancer-related molecular mechanisms research
- Gold and Silver Nanoparticles Synthesis and Applications
- Extracellular vesicles in disease
- Nonlinear Optical Materials Research
- Nanowire Synthesis and Applications
- Microfluidic and Bio-sensing Technologies
- Bone Metabolism and Diseases
- Plasmonic and Surface Plasmon Research
- Video Coding and Compression Technologies
- Air Quality and Health Impacts
- Advanced Nanomaterials in Catalysis
- Advanced Image Processing Techniques
- Graphene and Nanomaterials Applications
- Advanced Vision and Imaging
- Molecular Biology Techniques and Applications
Auburn University
2016-2025
Zhejiang University
2020-2025
Sir Run Run Shaw Hospital
2023-2025
National Taiwan University of Sport
2025
Beijing Forestry University
2022-2024
Nantong University
2024
Affiliated Hospital of Nantong University
2024
Wuhan University
2016-2024
Henan Provincial People's Hospital
2024
Henan University
2024
Precise monitoring of the rapidly changing immune status during course a disease requires multiplex analysis cytokines from frequently sampled human blood. However, current lack rapid, multiplex, and low volume assays makes for clinical decision-making (e.g., critically ill patients) impractical. Without such assays, is even virtually impossible infants neonates with infectious diseases and/or mediated disorders as access to their blood in large quantities prohibited. Localized surface...
Tumor cells are characterized as redox-heterogeneous intracellular microenvironment due to the simultaneous overproduction of reactive oxygen species and glutathione. Rational design redox-responsive drug delivery systems is a promising prospect for efficient cancer therapy. Herein, six paclitaxel-citronellol conjugates synthesized using either thioether bond, disulfide selenoether diselenide carbon bond or carbon-carbon linkages. These prodrugs can self-assemble into uniform nanoparticles...
Abstract Conventional buildings consume about 40% of global energy, smart window technologies have been developed for sunlight modulation and energy management. Most current windows change from transparent to opaque as the temperature rises, which is detrimental indoor lighting at daytime or privacy protection night. In this work, a versatile thermochromic hydrogel system by introducing sodium dodecyl sulfate (SDS) micelles into crosslinked copolymer hydrophilic acrylamide hydrophobic...
Postmenopausal osteoporosis (PMOP) is a chronic systemic bone metabolism disorder. Promotion in the patterns of human marrow mesenchymal stem cells (hBMSCs) differentiation towards osteoblasts contributes to alleviating osteoporosis. Aucubin, natural compound isolated from well-known herbal medicine Eucommia, was previously shown possess various pharmacological effects. However, its effects on hBMSCs PMOP patients are unknown. The aim this present research investigate impact and underlying...
Silver nanoparticles (Ag NPs) are extensively used as an antibacterial additive in commercial products and their release has caused environmental risk. However, conventional methods for the toxicity detection of Ag NPs very time consuming mechanisms action not clear. We developed a new, situ, rapid, sensitive fingerprinting approach, using surface-enhanced Raman spectroscopy (SERS), to study activity mechanism 80 18 nm (Ag80 Ag18, respectively), by strong electromagnetic enhancement...
The effects of ZnO nanoparticles (NPs) interacting with single-celled green algae, Chlorella sp., have been found to be bilateral. Specifically, our electron microscopy, plant cell, and fluorescence assays showed that the adsorption aggregation NPs compromised algal cell morphology, viability, membrane integrity, resulting from zinc ion dissolution as well possible mechanical damage induced by NPs. Conversely, cells displayed a remarkable capability self-protection minimizing their surface...
Disulfiram (DSF), an alcohol-aversion drug, has been explored for cancer treatment. Copper diethyldithiocarbamate (Cu(DDC)2) complex formed by DSF and copper ions is a major active ingredient its anticancer activity. Direct administration of Cu(DDC)2 promising strategy to enhance the efficacy DSF. However, efficient drug delivery remains significant challenge hinders clinical use. In this study, we developed facile stabilized metal ion ligand (SMILE) method prepare nanoparticles (NPs). The...
Multi-walled carbon nanotubes (MWCNTs) are widely used in many disciplines due to their unique physical and chemical properties. Therefore, some concerns about the possible human health environmental impacts of manufactured MWCNTs rising. We hypothesized that instillation impairs pulmonary function C57BL/6 mice development lung inflammation fibrosis. were administered by oropharyngeal aspiration (1, 2, 4 mg/kg) we assessed fibrosis inflammatory cell infiltration, collagen content,...
The advancement of nanomedicine and the increasing applications nanoparticles in consumer products have led to administered biological exposure unintentional environmental accumulation nanoparticles, causing concerns over biocompatibility sustainability nanotechnology. Upon entering physiological environments, readily assume form a nanoparticle–protein corona that dictates their identity. Consequently, understanding structure dynamics is essential for predicting fate, transport, toxicity...
Human islet amyloid polypeptide (hIAPP, or amylin) forms deposits in the islets of Langerhans, a phenomenon that is associated with type-2 diabetes impacting millions people worldwide. Accordingly, strategies against hIAPP aggregation are essential for prevention and eventual treatment disease. Here, it shown generation-3 OH-terminated poly(amidoamine) dendrimer, polymeric nanoparticle, can effectively halt shut down toxicity pancreatic MIN6 NIT-1 cells as well mouse islets. This finding...
Localized surface plasmon resonance (LSPR) nanoplasmonic effects allow for label-free, real-time detection of biomolecule binding events on a nanostructured metallic with simple optics and sensing tunability. Despite numerous reports LSPR bionanosensing in the past, no study thus far has applied technique cytokine secretion assay using clinically relevant immune cells from human blood. Cytokine assays, to quantify intercellular-signaling proteins secreted by blood cells, determination...
Tumor-derived exosomes play a vital role in the process of cancer development. Quantitative analysis and exosome-shuttled proteins would be immense value understanding progression generating reliable predictive biomarkers for diagnosis treatment. Recent studies have indicated critical exosomal programmed death ligand 1 (PD-L1) immune checkpoint therapy its application as patient stratification biomarker immunotherapy. Here, we present nanoplasmonic exosome immunoassay utilizing gold-silver...
Cytokine storm, known as an exaggerated hyperactive immune response characterized by elevated release of cytokines, has been described a feature associated with life-threatening complications in COVID-19 patients. A critical evaluation cytokine storm and its mechanistic linkage to requires innovative immunoassay technology capable rapid, sensitive, selective detection multiple cytokines across wide dynamic range at high-throughput. In this study, we report machine-learning-assisted...
In the field of catalytic asymmetric synthesis, less-treated path lies in oxidative transformations. The hurdles pinpointing appropriate chemical oxidants and addressing their compatibility issues with catalysts functionalities present significant challenges. Organic electrochemistry, employing traceless electrons for redox reactions, is underscored as a promising solution. However, commonly used electrolysis batch cells introduces its own set challenges, hindering advancement...
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Health care researchers have recently developed several home-based sleep monitoring systems and mobile applications that support healthy by a user's environment, activities, or quality. This study describes the design evaluation of an electrooculogram (EOG)-based system for automatic monitoring. Compared with polysomnogram electroencephalogram recordings, EOG has advantage easy placement can be operated users themselves. We also intelligent eye mask is user friendly measuring stage Two...
Human islet amyloid polypeptide (hIAPP or amylin) aggregation is directly associated with pancreatic β-cell death and subsequent insulin deficiency in type 2 diabetes (T2D). Since no cure currently available for T2D, it of great benefit to devise new anti-aggregation molecules, which protect β-cells against hIAPP aggregation-induced toxicity. Engineered nanoparticles have been recently exploited as nanomedicines. In this work, we studied graphene oxide (GO) nanosheets their potential...
Abstract Atomically layered transition metal dichalcogenides (TMDCs) exhibit a significant potential to enable next-generation low-cost transistor biosensors that permit single-molecule-level quantification of biomolecules. To realize such biosensing capability, device-oriented research is needed for calibrating the sensor responses affinities/kinetics biomolecule interactions. In this work, we demonstrated MoS 2 -based capable detecting tumor necrosis factor – alpha (TNF-α) with detection...
A biomimetic ‘adipose-tissue-on-chip’ integrated with nanoplasmonic biosensors for <italic>in situ</italic> multiplexed cytokine secretion analysis of obese adipose tissue.