A5100383661- Immune cells in cancer
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Immune Cell Function and Interaction
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer Immunotherapy and Biomarkers
- Photodynamic Therapy Research Studies
- Cancer, Stress, Anesthesia, and Immune Response
- Chemokine receptors and signaling
- Immunotherapy and Immune Responses
- Bone and Joint Diseases
- Cancer, Hypoxia, and Metabolism
- Stroke Rehabilitation and Recovery
- Advanced Nanomaterials in Catalysis
- Dendrimers and Hyperbranched Polymers
- Osteoarthritis Treatment and Mechanisms
- Liver Disease Diagnosis and Treatment
- Nanocluster Synthesis and Applications
- Advanced biosensing and bioanalysis techniques
- Advanced Battery Materials and Technologies
- Antifungal resistance and susceptibility
- Acute Myeloid Leukemia Research
- Epigenetics and DNA Methylation
- Balance, Gait, and Falls Prevention
- Adenosine and Purinergic Signaling
Tianjin Medical University General Hospital
2016-2025
Jiaxing University
2021-2024
Hangzhou Normal University
2024
Shenyang Pharmaceutical University
2018-2024
Jilin University
2024
First Affiliated Hospital of Zhengzhou University
2020-2024
Ningbo Medical Center Lihuili Hospital
2024
Ningbo University
2024
University of Shanghai for Science and Technology
2024
China Medical University
2023-2024
Disulfide bonds have been widely used to develop reduction-responsive drug-delivery systems (DDS) for cancer therapy. We propose that disulfide might be also as an oxidation-responsive linkage just like thioether bonds, which can oxidized hydrophilic sulfoxide or sulphone in the presence of oxidation stimuli. To test our hypothesis, we design three novel paclitaxel–citronellol conjugates linked via different lengths disulfide-bond-containing carbon chain. The prodrugs self-assemble into...
Tumor cells are characterized as redox-heterogeneous intracellular microenvironment due to the simultaneous overproduction of reactive oxygen species and glutathione. Rational design redox-responsive drug delivery systems is a promising prospect for efficient cancer therapy. Herein, six paclitaxel-citronellol conjugates synthesized using either thioether bond, disulfide selenoether diselenide carbon bond or carbon-carbon linkages. These prodrugs can self-assemble into uniform nanoparticles...
We previously showed that surface mannans of Candida albicans function as adhesins during yeast cell attachment to mouse splenic marginal zone macrophages. The mannan adhesin fraction was encapsulated into liposomes and used vaccinate mice over a 5- 6-week period. Circulating agglutinins specific for the correlated with increased resistance disseminated candidiasis. Antiserum from vaccinated animals protected naive BALB/cByJ against C. serotype A B strains tropicalis. also SCID disease....
Clinically, intra-articular administration can hardly achieve the truly targeted therapy, and drugs are usually insufficient to show local long-term therapeutic effects because of their rapid clearance. Herein, inspired by phenomenon that bees track scent flowers collect nectar, we developed cartilage-targeting hydrogel microspheres with reactive oxygen species (ROS)-responsive ability via combining microfluidic method photopolymerization processes integrate peptides ROS-responsive...
The tendon-bone interface has a complex gradient structure vital for stress transmission and pressure buffering during movement. However, injury to the tissue, especially tendon cartilage components, often hinders complete restoration of original structure. Here, metal ion network hydrogel scaffold, with capability targeting multitissue, was constructed through photopolymerization LHERHLNNN peptide-modified zeolitic imidazolate framework-8 (LZIF-8) WYRGRL magnesium metal-organic framework...
Phototherapy has been intensively investigated as a non-invasive cancer treatment option. However, its clinical translation is still impeded by unsatisfactory therapeutic efficacy and severe phototoxicity. To achieve high efficiency security, nanoassembly of Forster Resonance Energy Transfer (FRET) photosensitizer pairs developed on basis dual-mode co-loading photocaging strategy. For proof-of-concept, an erythrocyte-camouflaged FRET pair co-assembly chlorine e6 (Ce6, donor)...
Treatment of osteoarthritis (OA) remains a significant clinical challenge. Itaconate (IA), an emerging regulator intracellular inflammation and oxidative stress, may potentially be harnessed to treat OA. However, the short joint residence time, inefficient drug delivery, cell-impermeable property IA can seriously hamper translation. Herein, IA-encapsulated zeolitic imidazolate framework-8 (IA-ZIF-8) nanoparticles were self-assembled by zinc ions, 2-methylimidazole, render them pH-responsive....
Polyplex micelles were constructed for deep tumor tissue penetration and combating drug resistance via endogenous stimuli-responsive two-step release profiles.
A synergistic effect of photothermal and chemotherapy cancers was demonstrated using redox-responsive core cross-linked micelles fabricated from cypate cisplatin prodrugs-conjugated block copolymers.
To efficiently deliver anticancer drugs to the entire tumor tissue and cancer cells, an endogenous stimuli‐sensitive multistage polymeric micelleplex drug delivery system is developed via electrostatic complexation between poly(ethylene glycol)‐ block ‐poly[( N ′‐dimethylmaleoyl‐2‐aminoethyl)aspartamide]‐ ‐poly( ε ‐caprolactone) (PEG‐ b ‐PAsp(EDA‐DM)‐ ‐PCL) triblock copolymer micelles cisplatin prodrug (Pt(IV))‐conjugated cationic poly(amidoamine) dendrimers (PAMAM‐Pt(IV)). The micelleplexes...
Construction of efficient doxorubicin (DOX) delivery systems addressing a cascade physiological barriers remains great challenge for better therapeutic efficacy tumors. Herein, we design well-defined enzyme-responsive peptide-linked block copolymer, PEG-GPLGVRGDG-P(BLA-co-Asp) [PEG and P(BLA-co-Asp) are poly(ethylene glycol) partially hydrolyzed poly(β-benzyl l-aspartate) (PBLA), respectively] (P3), with modular functionality DOX. The copolymers were successfully obtained via click reaction...
Imaging-guided diagnosis and phototherapy has been emerging as promising theragnostic strategies for detection treatment of cancer. 1,1′-Dioctadecyl-3,3,3′,3′-tetramethylindotricarbocyanine iodide (DiR) widely investigated in vivo imaging photothermal therapy (PTT). However, the tumor-homing ability PTT efficiency DiR is greatly limited by its extremely low water solubility nonspecific distribution off-target tissues. Herein, a facile nanoassembly pure reported nanocarrier platform...