A5021248072- Genomics and Chromatin Dynamics
- Developmental Biology and Gene Regulation
- RNA Research and Splicing
- Ubiquitin and proteasome pathways
- Fungal and yeast genetics research
- RNA modifications and cancer
- CRISPR and Genetic Engineering
- Epigenetics and DNA Methylation
- RNA and protein synthesis mechanisms
- Cancer-related gene regulation
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Silk-based biomaterials and applications
- Invertebrate Immune Response Mechanisms
- Mitochondrial Function and Pathology
- Cell Adhesion Molecules Research
- Hippo pathway signaling and YAP/TAZ
- DNA Repair Mechanisms
- Cancer-related Molecular Pathways
- Neurobiology and Insect Physiology Research
- Gene Regulatory Network Analysis
- Neonatal and fetal brain pathology
- Immunotherapy and Immune Responses
- Aldose Reductase and Taurine
- Plant Pathogens and Fungal Diseases
- Chronic Myeloid Leukemia Treatments
Zhejiang University
2009-2025
Jiaxing University
2022-2025
Zhejiang International Studies University
2023-2024
Xiamen University
2024
Zhejiang Chinese Medical University
2022-2024
Wuhan University
2024
Renmin Hospital of Wuhan University
2024
Second Affiliated Hospital of Zhejiang University
2023-2024
Qilu Hospital of Shandong University
2024
Women's Hospital, School of Medicine, Zhejiang University
2022-2023
Carcinoma of unknown primary (CUP) is a type metastatic cancer, the tumor site which cannot be identified. CUP occupies approximately 5% cancer incidences in United States with usually unfavorable prognosis, making it big threat to public health. Traditional methods identify tissue-of-origin (TOO) like immunohistochemistry can only deal around 20% patients. In recent years, more and studies suggest that promising solve problem by integrating machine learning techniques biomedical data...
Circular RNAs (circRNAs) have emerged as significant biological regulators. Herein, we aimed to elucidate the role of an unidentified circRNA (circPDE4B) that is reportedly downregulated in osteoarthritis (OA) tissues.The effects circPDE4B were explored human and mouse chondrocytes vitro. Specifically, RNA pull-down (RPD)-mass spectrometry analysis (MS), immunoprecipitation, glutathione-S-transferase (GST) pull-down, immunoprecipitation RPD assays performed verify interactions between RIC8...
Clinically, intra-articular administration can hardly achieve the truly targeted therapy, and drugs are usually insufficient to show local long-term therapeutic effects because of their rapid clearance. Herein, inspired by phenomenon that bees track scent flowers collect nectar, we developed cartilage-targeting hydrogel microspheres with reactive oxygen species (ROS)-responsive ability via combining microfluidic method photopolymerization processes integrate peptides ROS-responsive...
Patients undergoing doxorubicin (Dox) chemotherapy often develop new-onset atrial fibrillation and heart failure. Recent studies indicate that the TLR4/MyD88/NLRP3 pyroptosis signaling pathway plays a key role in occurrence development of cancer, failure, atherosclerosis. However, few investigated oxidative stress doxorubicin-induced failure fibrillation. In this study, we recruited 84 healthy subjects, 112 patients Dox showing (HF), 62 treatment who manifested (AF). The mRNA protein levels...
N6-methyladenosine (m6A) is a critical regulator in the fate of RNA, but whether and how m6A executes its functions different tissues remains largely obscure. Here we report downregulation crucial reader, YTHDF2, leading to tissue-specific programmed cell deaths (PCDs) upon fluorene-9-bisphenol (BHPF) exposure. Currently, Bisphenol A (BPA) substitutes are widely used plastic manufacturing. Interrogating eight common BPA substitutes, detected BHPF 14% serum samples pregnant participants. In...
The tendon-bone interface has a complex gradient structure vital for stress transmission and pressure buffering during movement. However, injury to the tissue, especially tendon cartilage components, often hinders complete restoration of original structure. Here, metal ion network hydrogel scaffold, with capability targeting multitissue, was constructed through photopolymerization LHERHLNNN peptide-modified zeolitic imidazolate framework-8 (LZIF-8) WYRGRL magnesium metal-organic framework...
Pancreatic cancer is an aggressive malignancy with a high metastatic potential that results in mortality rate worldwide. Although macrophages have the to kill tumor cells and elicit immune responses against tumors, there evidence tumor-associated (TAMs) promote progression suppress T-cell responses. CC-chemokine ligand 20 (CCL20) its unique receptor 6 (CCR6) are exploited by for migration metastasis play important roles development of cancer. Recent studies shown expression CCL20 upregulated...
Osteoarthritis (OA), characterized as an end-stage syndrome caused by risk factors accumulated with age, significantly impacts quality of life in the elderly. Circular RNAs (circRNAs) are receiving increasing attention regarding their role OA progression and development; however, regulation age-induced oxidative stress-related remains unclear. Methods: Herein, we explored stress articular cartilage obtained from patients different ages. The presence circRSU1 was detected using RNA sequencing...
Reprogramming metabolism is a hallmark of cancer cells for rapid progression.However, the detailed functional role deubiquitinating enzymes (DUBs) in tumor glycolytic reprogramming still unknown and requires further investigation.USP13 was found to upregulate osteosarcoma (OS) specimens promote OS progression through regulating aerobic glycolysis.Interestingly, m 6 A writer protein, METTL3, has been identified as novel target USP13.USP13 interacts with, deubiquitinates, therefore stabilizes...
Treatment of osteoarthritis (OA) remains a significant clinical challenge. Itaconate (IA), an emerging regulator intracellular inflammation and oxidative stress, may potentially be harnessed to treat OA. However, the short joint residence time, inefficient drug delivery, cell-impermeable property IA can seriously hamper translation. Herein, IA-encapsulated zeolitic imidazolate framework-8 (IA-ZIF-8) nanoparticles were self-assembled by zinc ions, 2-methylimidazole, render them pH-responsive....
ABSTRACT The Drosophila morphogenetic protein Bicoid, encoded by the maternal gene bicoid, is required for development of anterior structures in embryo. a transcriptional activator containing homeodomain, distributed an anterior-to-posterior gradient In response to this gradient, zygotic hunchback expressed uniformly half embryo nearly all- or-none manner. report we demonstrate that recombinant Bicoid binds cooperatively its sites within enhancer element. A less than 4-fold increase...
We used mice with deletions in either the endothelial nitric oxide synthase (eNOS) or neuronal NOS (nNOS) gene to investigate role of eNOS and nNOS acetylcholine (ACh)-induced relaxation pial arterioles (20-30 microns). Pial arteriolar diameter was measured by intravital microscopy through a closed cranial window, activity determined conversion [3H]arginine [3H]citrulline subjacent cortex. ACh superfusion (1, 10 microM) caused atropine-sensitive dose-dependent dilation all three mouse...