A5082932410- Advanced Polymer Synthesis and Characterization
- Polymer Surface Interaction Studies
- Surfactants and Colloidal Systems
- Nanoparticle-Based Drug Delivery
- Dendrimers and Hyperbranched Polymers
- Luminescence and Fluorescent Materials
- Nanoplatforms for cancer theranostics
- Molecular Sensors and Ion Detection
- Hydrogels: synthesis, properties, applications
- Supramolecular Self-Assembly in Materials
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Click Chemistry and Applications
- Supramolecular Chemistry and Complexes
- biodegradable polymer synthesis and properties
- Block Copolymer Self-Assembly
- Analytical Chemistry and Sensors
- Polydiacetylene-based materials and applications
- Photochromic and Fluorescence Chemistry
- Chemical Synthesis and Analysis
- Gold and Silver Nanoparticles Synthesis and Applications
- Covalent Organic Framework Applications
- Lipid Membrane Structure and Behavior
University of Science and Technology of China
2016-2025
Xidian University
2024
Huawei Technologies (Sweden)
2024
Fanjingshan National Nature Reserve
2012-2024
Huawei Technologies (China)
2024
Collaborative Innovation Center of Chemistry for Energy Materials
2014-2022
China Pharmaceutical University
2022
Hefei National Center for Physical Sciences at Nanoscale
2010-2021
Southwestern University of Finance and Economics
2020
Institute of Economics
2020
Solution self-assembly of block copolymers (BCPs) typically generates spheres, rods, and vesicles. The reproducible bottom-up fabrication stable planar nanostructures remains elusive due to their tendency bend into closed bilayers. This morphological vacancy renders the study shape effects on BCP nanocarrier-cell interactions incomplete. Furthermore, single assemblies with built-in drug delivery functions geometry-optimized performance a major challenge. We demonstrate that PEG-b-PCPTM...
The past two decades have evidenced a tremendous growth in the field of responsive polymers, which can exhibit reversible or irreversible changes physical properties and/or chemical structures to an external stimulus such as pH, temperature, ionic strength, light irradiation, mechanical forces, electric and magnetic fields, specific analytes, additives (ions, bioactive molecules, etc.), combination them. Responsive polymers exist form solutions, gels, self-assembled nanoparticles,...
The trans form of an azobenzene-containing guest can complex with a pillar[6]arene, while it cannot pillar[5]arenes due to the different cavity sizes pillar[6]arene and pillar[5]arenes. spontaneous aggregation its host-guest be reversibly photocontrolled by irradiation UV visible light, leading switch between irregular aggregates vesicle-like aggregates. This new pillar[6]arene-based photoresponsive recognition motif work in organic solvents is good supplement existing widely used...
A series of well-defined poly[(ethylene oxide)-block-2-(dimethylamino)ethyl methacrylate-block-2-(diethylamino) methacrylate] (PEO−DMA−DEA) triblocks were synthesized by successive ATRP polymerization DMA and DEA monomers using PEO-based macroinitiators different molecular weights. These triblock copolymers dissolved molecularly in aqueous solution at low pH; on addition NaOH, micellization occurred pH 7.1 to form three-layer "onionlike" micelles comprising cores, inner shells, PEO coronas....
We report on the preparation of well-defined cyclic poly(N-isopropylacrylamide) (cyclic-PNIPAM) via click chemistry and its unique thermal phase transition behavior as compared to linear counterpart. α-Alkyne-ω-azido heterodifunctional PNIPAM precursor (linear-PNIPAM-N3) was prepared by atom transfer radical polymerization (ATRP) N-isopropylacrylamide in 2-propanol using propargyl 2-chloropropionate initiator, followed reacting with NaN3 transform terminal chloride into azide group. The...
The rational design of theranostic nanoparticles exhibiting synergistic turn-on therapeutic potency and enhanced diagnostic imaging in response to tumor milieu is critical for efficient personalized cancer chemotherapy. We herein fabricate self-reporting drug nanocarriers based on hyperbranched polyprodrug amphiphiles (hPAs) consisting cores conjugated with reduction-activatable camptothecin prodrugs magnetic resonance (MR) contrast agent (Gd complex), hydrophilic coronas functionalized...
We report on the fabrication of photochromic polymersomes exhibiting photoswitchable and reversible bilayer permeability from newly designed poly(ethylene oxide)-b-PSPA (PEO-b-PSPA) diblock copolymers, where SPA is spiropyran (SP)-based monomer containing a unique carbamate linkage. Upon self-assembling into polymersomes, SP moieties within vesicle bilayers undergo phototriggered isomerization between hydrophobic (SP, λ2 > 450 nm irradiation) zwitterionic merocyanine (MC, λ1 < 420 states....
Reactive oxygen species (ROS) and oxidative stress are implicated in various physiological pathological processes, this feature provides a vital biochemical basis for designing novel therapeutic diagnostic nanomedicines. Among them, oxidation-responsive micelles vesicles (polymersomes) of amphiphilic block copolymers have been extensively explored; however, previous works, oxidation by ROS including H2O2 exclusively leads to microstructural destruction polymeric assemblies. For polymersomes,...
Antimicrobial resistance poses serious public health concerns and antibiotic misuse/abuse further complicates the situation; thus, it remains a considerable challenge to optimize/improve usage of currently available drugs. We report general strategy construct bacterial strain-selective delivery system for antibiotics based on responsive polymeric vesicles. In response enzymes including penicillin G amidase (PGA) β-lactamase (Bla), which are closely associated with drug-resistant strains,...
The development of a highly selective and fast responsive fluorogenic biosensor for diverse analytes ranging from bioactive small molecules to specific antigens is desirable but remains considerable challenge. We herein propose new approach by integrating substrate-selective enzymatic reactions with fluorogens exhibiting aggregation-induced emission feature. Tyrosine-functionalized tetraphenylethene, TPE-Tyr, molecularly dissolves in aqueous media negligible fluorescence emission; upon...
Stimuli-triggered disassembly of block copolymer vesicles or polymersomes has been conventionally achieved via solubility switching the bilayer-forming block, requiring cooperative changes most repeating units. Herein we report an alternative approach by incorporating hydrophobic blocks exhibiting stimuli-triggered head-to-tail cascade depolymerization features. Amphiphilic copolymers bearing this motif self-assemble into self-immolative (SIPsomes). By modular design terminal capping...
ConspectusAll living organisms and soft matter are intrinsically responsive adaptive to external stimuli. Inspired by this fact, tremendous effort aiming emulate subtle features exhibited nature has spurred the invention of a diverse range polymeric materials. Conventional stimuli-responsive polymers constructed via covalent bonds can undergo reversible or irreversible changes in chemical structures, physicochemical properties, both response variety They have been imparted with emerging...
The fabrication of block copolymer (BCP) vesicles (polymersomes) exhibiting synchronized covalent crosslinking and bilayer permeabilization remains a considerable challenge as typically leads to compromised membrane permeability. Herein it is demonstrated how solve this dilemma by employing stimuli-triggered strategy with amphiphilic BCPs containing photolabile carbamate-caged primary amines. Upon self-assembling into polymersomes, light-triggered self-immolative decaging reactions release...
This review presents the recent developments in research hotspots of advanced functional polymers; their concepts, design strategies, and applications are briefly discussed.
The development of near-infrared (NIR) J-aggregates has received increasing attention due to their broad applications. Here, we report the nitrosation an amine-containing aza-BODIPY precursor (BDP-NH2 ), affording first nitric oxide (NO)-releasing NIR J-aggregate (BDP-NO). introduction N-nitrosamine moieties efficiently inhibits aromatic interactions BDP-NH2 , which instead promotes formation within micellar nanoparticles with a remarkable bathochromic shift ≈109 nm window (820 nm)....
The formation of biofilms is closely associated with persistent and chronic infections, physiological heterogeneity such as pH oxygen gradients renders highly resistant to conventional antibiotics. To date, effectively treating biofilm infections remains a significant challenge. Herein, we report the fabrication micellar nanoparticles adapted heterogeneous microenvironments, enabling nitric oxide (NO) release through two distinct photoredox catalysis mechanisms. key design feature involves...
Schizophrenic character: A novel zwitterionic AB diblock copolymer was prepared by atom-transfer radical polymerization (ATRP) of 2-(diethylamino)ethyl methacrylate (DEA) and 4-vinyl benzoic acid (VBA). Both conventional micelles inverted can be formed in aqueous solution at ambient temperature, controlling the pH. At low pH, VBA-core (A) are formed, high pH DEA-core (B) neutral system precipitates (C; see figure).
Poly[(ethylene oxide)-block-glycerol monomethacrylate-block-2-(diethylamino)ethyl methacrylate] (PEO−GMA−DEA) and poly[(ethylene oxide)-block-2-hydroxyethyl methacrylate-block-2-(diethylamino)ethyl (PEO−HEMA−DEA) triblock copolymers were synthesized directly, without recourse to protecting group chemistry, via atom transfer radical polymerization by successive of GMA (or HEMA) DEA monomers using a PEO-based macroinitiator. These dissolved molecularly in aqueous solution at low pH; on...