A5084280956- Supramolecular Chemistry and Complexes
- Nanoplatforms for cancer theranostics
- Supramolecular Self-Assembly in Materials
- Luminescence and Fluorescent Materials
- Molecular Sensors and Ion Detection
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Advanced Nanomaterials in Catalysis
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Metal-Organic Frameworks: Synthesis and Applications
- Porphyrin and Phthalocyanine Chemistry
- Immunotherapy and Immune Responses
- Photodynamic Therapy Research Studies
- Dendrimers and Hyperbranched Polymers
- Advanced biosensing and bioanalysis techniques
- Extracellular vesicles in disease
- Photoacoustic and Ultrasonic Imaging
- Crystallography and molecular interactions
- Immune cells in cancer
- Monoclonal and Polyclonal Antibodies Research
- SARS-CoV-2 and COVID-19 Research
- Gold and Silver Nanoparticles Synthesis and Applications
- Graphene and Nanomaterials Applications
- Polydiacetylene-based materials and applications
Tsinghua University
2021-2025
Zhejiang University
2013-2023
First Affiliated Hospital Zhejiang University
2023
National Institute of Biomedical Imaging and Bioengineering
2016-2021
National Institutes of Health
2016-2021
State Key Laboratory of Chemical Engineering
2014-2021
Hangzhou Xixi hospital
2014-2018
State Key Laboratory of Food Science and Technology
2018
Nanchang University
2018
Nanjing University
2018
Chemodynamic therapy (CDT) employs Fenton catalysts to kill cancer cells by converting intracellular H2O2 into hydroxyl radical (•OH), but endogenous is insufficient achieve satisfactory anticancer efficacy. Despite tremendous efforts, engineering CDT agents with specific and efficient self-supplying ability remains a great challenge. Here, we report the fabrication of copper peroxide (CP) nanodot, which first example Fenton-type metal nanomaterial, its use as an activatable agent for...
Abstract Glucose is a key energy supplier and nutrient for tumor growth. Herein, inspired by the glucose oxidase (GOx)‐assisted conversion of into gluconic acid toxic H 2 O , novel treatment paradigm starving‐like therapy developed significant tumor‐killing effects, more effective than conventional starving only cutting off supply. Furthermore, generated acidic can oxidize l ‐Arginine ( ‐Arg) NO enhanced gas therapy. By using hollow mesoporous organosilica nanoparticle (HMON) as...
The trans form of an azobenzene-containing guest can complex with a pillar[6]arene, while it cannot pillar[5]arenes due to the different cavity sizes pillar[6]arene and pillar[5]arenes. spontaneous aggregation its host-guest be reversibly photocontrolled by irradiation UV visible light, leading switch between irregular aggregates vesicle-like aggregates. This new pillar[6]arene-based photoresponsive recognition motif work in organic solvents is good supplement existing widely used...
The complexation between a water-soluble pillar[6]arene (WP6) and paraquat (G1) in water was investigated. They could form stable 1:1 [2]pseudorotaxane with an extremely high association constant of (1.02 ± 0.10) × 108 M–1 mainly driven by electrostatic interactions, hydrophobic π–π stacking interactions. This molecular recognition has not only binding strength but also pH-responsiveness. threading dethreading processes this be reversibly controlled changing the solution pH. novel motif...
The first water-soluble pillar[6]arene was synthesized. Its water solubility can be reversibly controlled by changing the pH. This control used in reversible transformations between nanotubes and vesicles dispersion of multiwalled carbon water.
Abstract Reactive oxygen species (ROS)‐induced apoptosis is a widely practiced strategy for cancer therapy. Although photodynamic therapy (PDT) takes advantage of the spatial–temporal control ROS generation, meticulous participation light, photosensitizer, and greatly hinders broad application PDT as first‐line treatment option. An activatable system has been developed that enables tumor‐specific singlet ( 1 O 2 ) generation therapy, based on Fenton‐like reaction between linoleic acid...
A novel sugar-functionalized amphiphilic pillar[5]arene containing galactose groups as the hydrophlic part and alkyl chains hydrophobic was designed synthesized. It self-assembles in water to produce nanotubes confirmed by TEM, SEM, fluorescence microscopy. These nanotubes, showing low toxicity both cancer normal cells, can be utilized excellent cell glues agglutinate E. coli. The existence of galactoses on these provides multivalent ligands that have high affinity for carbohydrate receptors
Abstract Effectively activating macrophages against cancer is promising but challenging. In particular, cells express CD47, a ‘don’t eat me’ signal that interacts with regulatory protein alpha (SIRPα) on to prevent phagocytosis. Also, secrete stimulating factors, which polarize tumor-associated from an antitumor M1 phenotype tumorigenic M2 phenotype. Here, we report hybrid cell membrane nanovesicles (known as hNVs) displaying SIRPα variants significantly increased affinity CD47 and...
Abstract The combination of chemotherapeutic drugs and reactive oxygen species (ROS) is a promising strategy to achieve improved anticancer effect. Herein, nanomedicine (LaCIONPs) that can tumor‐specific drug release ROS generation developed for cancer chemo/chemodynamic therapy. LaCIONPs are constructed by encapsulation iron oxide nanoparticles (IONPs) β‐lapachone (La) in nanostructure assembled hydrogen peroxide (H 2 O )‐responsive polyprodrug pH‐responsive polymer. Through the enhanced...
A solvent-driven doubly threaded rotaxane dimer based on an amino-modified copillar[5]arene was prepared using bis(trifluoromethyl)phenyl isocyanate as stoppers. By comparison of proton NMR spectra the and control compound, inclusion-induced shielding effects decyl protons dumbbell compound were estimated. From crystal structures previously reported analogous pillar[5]arene/alkane pseudorotaxanes, we know that four methylenes can be totally encapsulated in pillar[5]arene cavity. When a is...
Nanomedicines have achieved several breakthroughs in cancer treatment over the past decades; however, their potential immunotoxicities are ignored, which results serious adverse effects and greatly reduces clinical translation. Herein, we innovatively develop a theranostic supramolecular polymer using β-cyclodextrin as host camptothecin (CPT) guest linked by glutathione-cleavable disulfide bond. The polymerization remarkably increases solubility of CPT factor 232 effectively inhibits its...
Light-emitting supramolecular coordination complexes (SCCs) have been widely studied for applications in the chemical and biological sciences. Herein, we report coordination-driven self-assembly of two highly emissive platinum(II) triangles (1 2) containing BODIPY-based bridging ligands. The metallacycles exhibit favorable anticancer activities against HeLa cells (IC50 6.41 2.11 μM). characteristic ∼570 nm fluorescence boron dipyrromethene (BODIPY) moieties permits their intracellular...
Combination therapy that could better balance immune activation and suppressive signals holds great potential in cancer immunotherapy. Herein, we serendipitously found the pH-responsive nanovesicles (pRNVs) self-assembled from block copolymer polyethylene glycol-b-cationic polypeptide can not only serve as a nanocarrier but also cause immunogenic cell death (ICD) through preapoptotic exposure of calreticulin. After coencapsulation photosensitizer, 2-(1-hexyloxyethyl)-2-devinyl...
Abstract Photodynamic therapy is an effective alternative to traditional treatments due its minimally invasive nature, negligible systemic toxicity, fewer side effects, and avoidance of drug resistance. However, it still challenging design photosensitizers with high singlet oxygen ( 1 O 2 ) quantum yields (QY) severe aggregation the hydrophobic photosensitizers. Herein, we developed a discrete organoplatinum(II) metallacage using therapeutic cis -(PEt 3 Pt(OTf) as building block improve QY,...
Metallacyclic cores provide a scaffold upon which pendant functionalities can be organized to direct the formation of dimensionally controllable nanostructures. Because modularity coordination-driven self-assembly, properties given supramolecular core readily tuned, has significant effect on resulting nanostructured material. Herein we report efficient preparation two amphiphilic rhomboids that subsequently order into 0D micelles, 1D nanofibers, or 2D nanoribbons. This structural diversity...
A rationally designed bi-adjuvant nanovaccine enhances neoantigen immunogenicity and enables combination immunotherapy.
Current chemodynamic therapy (CDT) primarily relies on the delivery of transition metal ions with Fenton activity to trigger hydroxyl radical production from hydrogen peroxide. However, administration an excess amount exogenous Fenton-type heavy metals may cause potential adverse effects human health, including acute and chronic damages. Here, we present a new CDT strategy that uses intracellular labile iron pool (LIP) as endogenous source Fenton-reactive for eliciting free generation,...
The development of smart theranostic systems with favourable biocompatibility, high loading efficiency, excellent circulation stability, potent anti-tumour activity, and multimodal diagnostic functionalities is importance for future clinical application. premature burst release poor degradation kinetics indicative polymer-based nanomedicines remain the major obstacles translation. Herein we prepare shell-crosslinked nanoparticles (SCNPs) using a β-cyclodextrin-based polyrotaxane...
The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has highlighted the urgent need to rapidly develop therapeutic strategies for such emerging viruses without effective vaccines or drugs. Here, we report a decoy nanoparticle against through powerful two-step neutralization approach: virus in first step followed cytokine second step. nanodecoy, made fusing cellular membrane nanovesicles derived from human monocytes and genetically engineered cells...
The clinical application of chemodynamic therapy is impeded by the insufficient intracellular H