A5052486663- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Circular RNAs in diseases
- Immune cells in cancer
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Immune Cell Function and Interaction
- RNA Research and Splicing
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- Autophagy in Disease and Therapy
- Ubiquitin and proteasome pathways
- Ion channel regulation and function
- Galectins and Cancer Biology
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Immunotherapy and Immune Responses
- Lung Cancer Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Inflammasome and immune disorders
- Bioinformatics and Genomic Networks
- interferon and immune responses
Chongqing Cancer Hospital
2022-2025
Chongqing University
2021-2025
China Agricultural University
2023-2025
Ministry of Agriculture and Rural Affairs
2021-2025
Jilin Agricultural University
2013-2025
Nanjing Agricultural University
2025
Southeast University
2025
Guangzhou University of Chinese Medicine
2019-2025
Zhengzhou People's Hospital
2015-2025
Nanchang University
2014-2024
Abstract Effectively activating macrophages against cancer is promising but challenging. In particular, cells express CD47, a ‘don’t eat me’ signal that interacts with regulatory protein alpha (SIRPα) on to prevent phagocytosis. Also, secrete stimulating factors, which polarize tumor-associated from an antitumor M1 phenotype tumorigenic M2 phenotype. Here, we report hybrid cell membrane nanovesicles (known as hNVs) displaying SIRPα variants significantly increased affinity CD47 and...
Angiogenesis is a key event in the progression of gliomas. Exosomes, as signaling extracellular organelles, modulate tumor microenvironment and promote angiogenesis progression. We previously demonstrated that long intergenic non-coding RNA CCAT2 (linc-CCAT2) was overexpressed glioma tissues functioned to Therefore, this study aimed explore an underlying mechanism cell-affected angiogenesis. First, qRT-PCR used determine expression level linc-CCAT2 4 cell lines 293T cells, results revealed...
Abstract Immunosuppression is common in head and neck squamous cell carcinoma (HNSCC). In previous studies, the TIGIT/CD155 pathway was identified as an immune-checkpoint signaling that contributes to “exhaustion” state of infiltrating T cells. Here, we sought explore clinical significance HNSCC identify therapeutic effect a transgenic mouse model. TIGIT overexpressed on tumor-infiltrating CD8+ CD4+ cells both patients models, correlated with molecules (PD-1, TIM-3, LAG-3). also expressed...
Abstract A major challenge for traditional cancer therapy, including surgical resection, chemoradiotherapy, and immunotherapy, is how to induce tumor cell death leverage the host immune system at same time. Here, a myeloid‐derived suppressor (MDSC) membrane‐coated iron oxide magnetic nanoparticle (MNP@MDSC) overcome this conundrum therapy developed. In study, MNP@MDSC demonstrates its superior performance in evasion, active tumor‐targeting, resonance imaging, photothermal (PTT)‐induced...
The prognostic value of N6-methylandenosine-related long non-coding RNAs (m6A-related lncRNAs) was investigated in 646 lower-grade glioma (LGG) samples from Cancer Genome Atlas (TCGA) and the Chinese Glioma (CGGA) datasets. We implemented Pearson correlation analysis to explore m6A-related lncRNAs, then univariate Cox regression performed screen their roles LGG patients. Twenty-four lncRNAs were identified as they inputted a least absolute shrinkage selection operator (LASSO) establish...
Head and neck cancer is one of the most prevalent cancers around world. squamous cell carcinoma (HNSCC) accounts for nearly 90% head cancer. In recent years, significant advances have been made in immunotherapy HNSCC. Although some clinical trials targeting immune checkpoints shown success, molecular mechanism regulation programmed death 1 (PD-1) its ligand (PD-L1) partially understood. an effort to explore effect activation signal transducers activators transcriptions (STAT3) on PD-1/PD-L1,...
NLRP3 inflammasome acts as a danger signal sensor that triggers and coordinates the inflammatory response. However, roles of in tumorigenesis development cancer stem cells (CSCs) squamous cell carcinoma head neck (SCCHN) remain ambiguous. In our study, tissue microarrays, ELISA, sphere-forming assay, colony formation assay Western blot analysis were performed to evaluate effect on CSCs human SCCHN specimen, lines, transgenic mouse model. The components inflammasome, namely, NLRP3, ASC,...
T-cell immunoglobulin mucin 3 (TIM3) is a negative immune checkpoint and plays crucial part in tumor-induced suppression. However, the mechanism of TIM3 regulating immunosuppression head neck squamous cell carcinoma (HNSCC) was still not quite clear.We carried out immunohistochemistry staining HNSCC tissue microarrays. Through quantification histoscore, we performed correlation analysis among TIM3, Galectin-9, Foxp3, CD68 CD163. The effects on regulatory T cells (Tregs) macrophages were...
// Li-Juan Wang 1 , Chen-Chen He Xin Sui Meng-Jiao Cai Cong-Ya Zhou Jin-Lu Ma Lei Wu 1,2 Hao Su-Xia Han and Qing Zhu Department of Oncology, the First Affiliated Hospital Medical School Xi'an Jiaotong University, Xi'an, Shaanxi Province, P.R. China 2 Center Radiotherapy, Provincial Tumor Hospital, Correspondence to: Zhu, email: Keywords : Intrahepatic cholangiocarcinoma, miR-21, PTPN14, PTEN, tumorigenesis Received November 07, 2014 Accepted January 20, 2015 Published February 28, Abstract...
Angiogenesis is an essential event in tumor growth and metastasis, immune system also contributes to the evasion. Emerging evidences have suggested bidirectional link between angiogenesis immunosuppression. Myeloid‐derived suppressor cell (MDSC) a kind of immunosuppressive cells plays important role this process. However, actual regulatory mechanisms MDSCs head neck squamous carcinoma (HNSCC) were unclear. In study, through analyzing immunohistochemistry staining human HNSCC tissue...
Abstract RNA methylation can reverse the modification at level, which is an extremely important epigenetic modification. The function and mechanism of YTHDF2, as a reader m6A modification, in epithelial ovarian cancer (EOC) have not been elucidated so far. This study aimed to investigate how YTHDF2 miR-145 modulated EOC progression through It demonstrated that was significantly upregulated tissues compared with normal tissues. Further functional studies confirmed promoted proliferation...
Background: Topoisomerase IIA (TOP2A) gene encodes DNA topoisomerase enzyme and has been reported that TOP2A is broadly expressed in many types of cancers.Our study aims to investigate the prognostic effect on lung adenocarcinoma (LUAD) potential molecular mechanism tumorigenesis.Methods: Bioinformatical analysis, real-time PCR Western blot were applied explore expression level TOP2A.Kaplan-Meier survival analysis was used evaluate patients' prognosis.Cell proliferation, migration invasion...
Background: Oxaliplatin (OXA) resistance is a main obstacle to the chemotherapy of colorectal cancer (CRC). Epithelial-mesenchymal transition (EMT), which mainly regulated by TGF-β/Smad signaling pathway, has gradually been recognized as an important mechanism for tumor chemoresistance. Studies have shown that curcumin EMT processes in many human cancers. However, whether could regulate OXA CRC through modulating signaling-mediated remains unclear. Methods: In attempt investigate effect on...
Abstract Overcoming innate or adaptive resistance to immune checkpoint inhibitor therapy in solid tumors with limited T‐cell responses remains challenging. Increasing evidence has indicated that epigenetic alterations, especially overexpression of DNA methyltransferase and immunosuppressive adenosine, are major obstacles T cell activation. Here, a tumor microenvironment (TME) inspired prodrug nanomicelle (AOZN) composed the modulator γ‐oryzanol (Orz), adenosine α, β‐methylene 5′ diphosphate...
Background Protein disulfide isomerase A3 (PDIA3) is a member of the protein (PDI) family that participates in folding through its function. It has been reported to regulate progression several cancers, but function cancer immunotherapy unknown. Methods The RNA-seq data and normal tissues were downloaded from Cancer Genome Atlas (TCGA) Genotype-Tissue Expression (GTEx) databases. Cbioportal dataset was used explore genomic alteration information PDIA3 pan-cancer. Human (HPA) ComPPI websites...
Abstract Background Transporter associated with antigen processing 1 (TAP1) is a molecule involved in and presentation of major histocompatibility complex class I restricted antigens, including tumor-associated antigens. TAP1 participates tumor immunity, aberrantly expressed multiple cancer types; Methods Transcriptome profiles were obtained from The Cancer Genome Atlas Genotype-Tissue Expression databases. Genetic alterations, protein distribution, interaction information for downloaded...
Immune evasion is a hallmark feature of cancer, and it plays an important role in tumour initiation progression. In addition, immune severely hampers the desired antitumour effect multiple cancers. this study, we aimed to investigate Notch pathway head neck squamous cell carcinoma (HNSCC) microenvironment. We first demonstrated that Notch1 signaling was activated Tgfbr1/Pten-knockout HNSCC mouse model. inhibition using γ-secretase inhibitor (GSI-IX, DAPT) decreased burden model after...