A5100333593- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- Cancer-related molecular mechanisms research
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Radiomics and Machine Learning in Medical Imaging
- Circular RNAs in diseases
- Gastric Cancer Management and Outcomes
- Cancer Genomics and Diagnostics
- Hepatitis B Virus Studies
- MicroRNA in disease regulation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Viral-associated cancers and disorders
- Salivary Gland Tumors Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Epigenetics and DNA Methylation
- CAR-T cell therapy research
- Cancer Cells and Metastasis
- Rice Cultivation and Yield Improvement
- Estrogen and related hormone effects
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Ferroptosis and cancer prognosis
Sun Yat-sen University
2016-2025
Sun Yat-sen University Cancer Center
2016-2025
Shanghai Tenth People's Hospital
2014-2025
Tongji University
2014-2025
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2021-2025
Shanghai University of Traditional Chinese Medicine
2021-2025
Sichuan University
2013-2025
Soochow University
2013-2025
University of Miami
2022-2025
Zunyi Medical University
2023-2025
Purpose There is currently no standard treatment strategy for patients with advanced metastatic gastric cancer experiencing progression after two or more lines of chemotherapy. We assessed the efficacy and safety apatinib, a novel vascular endothelial growth factor receptor 2 tyrosine kinase inhibitor, in gastroesophageal junction adenocarcinoma whom at least prior chemotherapy had failed. Patients Methods This was randomized, double-blind, placebo-controlled phase III trial. from 32 centers...
Platinum-based concurrent chemoradiotherapy is the standard of care for patients with locoregionally advanced nasopharyngeal carcinoma. Additional gemcitabine and cisplatin induction chemotherapy has shown promising efficacy in phase 2 trials.
In this study, we collected a total of 610 hospitalized patients from Wuhan between February 2, 2020, and 17, 2020. We reported potentially high false negative rate real-time reverse-transcriptase polymerase chain reaction (RT-PCR) testing for SARS-CoV-2 in the clinically diagnosed with COVID-19 during 2019 outbreak. also found that RT-PCR results several tests at different points were variable same course diagnosis treatment these patients. Our indicate addition to emphasis on testing,...
We aimed to evaluate the value of deep learning on positron emission tomography with computed (PET/CT)-based radiomics for individual induction chemotherapy (IC) in advanced nasopharyngeal carcinoma (NPC).
To report long‐term results of a randomized controlled trial that compared cisplatin/fluorouracil/docetaxel (TPF) induction chemotherapy (IC) plus concurrent chemoradiotherapy (CCRT) with CCRT alone in locoregionally advanced nasopharyngeal carcinoma (NPC). Patients stage III–IVB (except T3–4 N0) NPC were randomly assigned to receive IC (n = 241) or 239). included three cycles docetaxel (60 mg/m 2 d1), cisplatin and fluorouracil (600 /d civ d1–5) every 3 weeks. from both groups received...
Abstract Immunosuppression is common in head and neck squamous cell carcinoma (HNSCC). In previous studies, the TIGIT/CD155 pathway was identified as an immune-checkpoint signaling that contributes to “exhaustion” state of infiltrating T cells. Here, we sought explore clinical significance HNSCC identify therapeutic effect a transgenic mouse model. TIGIT overexpressed on tumor-infiltrating CD8+ CD4+ cells both patients models, correlated with molecules (PD-1, TIM-3, LAG-3). also expressed...
Background The prognosis of patients who have Epstein‐Barr virus (EBV)‐related nasopharyngeal carcinoma (NPC) in which the tumor tissues harbor EBV a better than those without EBV‐related NPC. Therefore, eighth edition TNM staging system could be modified for NPC by incorporating measurement plasma DNA. Methods In total, 979 with received intensity‐modulated radiotherapy (IMRT) were retrospectively reviewed. Recursive partitioning analysis was conducted based on (T) classification, lymph...
Importance Gastric and gastroesophageal junction cancers are diagnosed in more than 1 million people worldwide annually, few effective treatments available. Sintilimab, a recombinant human IgG4 monoclonal antibody that binds to programmed cell death (PD-1), combination with chemotherapy, has demonstrated promising efficacy. Objective To compare overall survival of patients unresectable locally advanced or metastatic gastric who were treated sintilimab chemotherapy vs placebo chemotherapy....
<h3>Importance</h3> Concurrent chemoradiotherapy has been the standard treatment for stage II nasopharyngeal carcinoma (NPC) based on data using 2-dimensional conventional radiotherapy. There is limited evidence role of chemotherapy with use intensity-modulated radiation therapy (IMRT). <h3>Objective</h3> To assess whether concurrent can be safely omitted patients low-risk II/T3N0 NPC treated IMRT. <h3>Design, Setting, and Participants</h3> This multicenter, open-label, randomized, phase 3,...
Clinical trials frequently include multiple end points that mature at different times. The initial report, typically on the based primary point, may be published when key planned co-primary or secondary analyses are not yet available. Trial Updates provide an opportunity to disseminate additional results from studies, in JCO elsewhere, for which point has already been reported.We previously reported significantly improved failure-free survival using gemcitabine plus cisplatin induction...