A5006186399- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- COVID-19 and Mental Health
- SARS-CoV-2 and COVID-19 Research
- COVID-19 and healthcare impacts
- Healthcare professionals’ stress and burnout
- Respiratory viral infections research
- Viral Infections and Immunology Research
- Extracellular vesicles in disease
- Pleural and Pulmonary Diseases
- Lung Cancer Diagnosis and Treatment
- Receptor Mechanisms and Signaling
- Intensive Care Unit Cognitive Disorders
- Regional Economic and Spatial Analysis
- Gut microbiota and health
- Employment and Welfare Studies
- Thermal Regulation in Medicine
- Sepsis Diagnosis and Treatment
- Influenza Virus Research Studies
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diabetes Management and Research
- Alcohol Consumption and Health Effects
- Meat and Animal Product Quality
- Nanopore and Nanochannel Transport Studies
- Hydrogen's biological and therapeutic effects
Wuhan Union Hospital
2020-2025
Huazhong University of Science and Technology
2020-2024
Zhongnan University of Economics and Law
2024
Union Hospital
2020-2024
Union Hospital
2020-2023
Zunyi Normal College
2018-2020
First Hospital of Qinhuangdao
2018-2019
Foshan University
2018
Fujian Agriculture and Forestry University
2014
Heilongjiang Center for Tuberculosis Control and Prevention
2014
Abstract Background The coronavirus disease 2019 (COVID-19), caused by infection with the severe acute respiratory syndrome 2 (SARS-CoV-2), has been rapidly spreading nationwide and abroad. A serologic test to identify antibody dynamics response SARS-CoV-2 was developed. Methods antibodies against were detected an enzyme-linked immunosorbent assay based on recombinant nucleocapsid protein of in patients confirmed or suspected COVID-19 at 3–40 days after symptom onset. gold standard for...
Hyperglycaemia is associated with an elevated risk of mortality in community-acquired pneumonia, stroke, acute myocardial infarction, trauma and surgery, among other conditions. In this study, we examined the relationship between fasting blood glucose (FBG) 28-day coronavirus disease 2019 (COVID-19) patients not previously diagnosed as having diabetes.We conducted a retrospective study involving all consecutive COVID-19 definitive outcome FBG measurement at admission from 24 January 2020 to...
Abstract Human microorganisms, including bacteria, fungi, and viruses, play key roles in several physiological pathological processes. Some studies discovered that tumour tissues once considered sterile actually host a variety of which have been confirmed to be closely related oncogenesis. The concept intratumoural microbiota was subsequently proposed. Microbiota could colonise through mucosal destruction, adjacent tissue migration, hematogenic invasion affect the biological behaviour...
Long coronavirus disease 2019 (COVID-19) in recovered patients (RPs) is gradually recognized by more people. However, how long it will last and the underlining mechanism remains unclear.We conducted a prospective follow-up study to evaluate long-term symptoms clinical indices of RPs at one-year after discharge from Union Hospital, Wuhan, China between December 2020 May 2021. We also performed 16S rRNA sequencing stool samples healthy controls (HCs) analyzed correlation gut microbiota...
The outbreak of COVID-19 in China was a sudden bio-disaster, which may bring negative impact on the job burnout health care professionals (HCPs).
Abstract Background Coronavirus disease 2019 (COVID-19) has become a public health emergency of global concern. We aimed to explore the risk factors 14-day and 28-day mortality develop model for predicting survival probability among adult hospitalized patients with COVID-19. Methods In this multicenter, retrospective, cohort study, we examined 828 confirmed COVID-19 in Wuhan Union Hospital Central between January 12 February 9, 2020. Among patients, 516 186 consecutive admitted were enrolled...
Autophagy plays an important role in the interaction between viruses and host cells. SARS-CoV-2 infection can disrupt autophagy process target However, precise molecular mechanism is still unknown. In this study, we discovered that Nsp8 of could cause increasing accumulation autophagosomes by preventing fusion lysosomes. From further investigation, found was present on mitochondria damage to initiate mitophagy. The results experiments with immunofluorescence revealed induced incomplete...
Objective This study aimed to analyze the association between activity of daily living (ADL), coronavirus disease (COVID-19), and value Barthel Index in predicting prognosis patients. Methods included 398 patients with COVID-19, whose ADL at admission hospital were assessed Index. The relationship index mortality risk was analyzed. Several regression models a decision tree established evaluate prognostic COVID-19 Results scores deceased significantly lower than that discharged (median: 65...
Abstract More and more patients suffered from Coronavirus disease 2019 (COVID-19) have got recovery gradually due to suitable intervention. Increasing data mainly studies the clinical characteristics of recovered COVID-19 patients, their molecular changes especially proteome also play same important role in understanding biological as do. In our study, we reported whole lung-ground glass-CT value-average mild/severe 3 months after discharge without underlying diseases was significantly lower...
This paper aims to unearth the ways in which Chinese government uses policies guide corporate social responsibility (CSR) development China. Co-word analysis, cluster and network analysis were conducted on relevant policy documents from 2005 2013 government. illustrates evolution of industry involvement metagovernance CSR, intergovernmental relations CSR formulation, guiding CSR. The quantitative text reveals intentions maps process, advancing understanding orientation evolution. reports...
Background: It remains unclear whether discharged COVID-19 patients have fully recovered from severe complications, including the differences in post-infection metabolomic profiles of with different disease severities. Methods: COVID-19-recovered patients, who had no previous underlying diseases and were Wuhan Union Hospital for 3 months, matched healthy controls (HCs) recruited this prospective cohort study. We examined blood biochemical indicators, cytokines, lung computed tomography...
Cellular immunity may be involved in organ damage and rehabilitation patients with coronavirus disease 2019 (COVID-19). We aimed to delineate immunological features of COVID-19 pulmonary sequelae (PS) 1 year after discharge. Fifty survivors were recruited classified according radiological characteristics, including 24 PS 26 without PS. Phenotypic functional characteristics immune cells evaluated by multiparametric flow cytometry. Patients had an increased proportion natural killer (NK) a...
Previous studies suggest that autonomic dysfunction is associated with disease severity in acute phase patients coronavirus 2019 (COVID-19). However, the association between and pulmonary sequelae COVID-19 unknown. We conducted a prospective study to investigate discharged for 6 months. included 40 eligible participants collected following indicators: heart rate variability (HRV), function tests (PFTs), lung X-ray computed tomography (CT), routine blood parameters, liver lymphocyte subsets....
Timely identification of epidermal growth factor receptor (EGFR) mutation and anaplastic lymphoma kinase (ALK) rearrangement status in patients with non-small cell lung cancer (NSCLC) is essential for tyrosine inhibitors (TKIs) administration. We aimed to use artificial intelligence (AI) models predict EGFR mutations ALK using common demographic features, pathology serum tumor markers (STMs).In this single-center study, pathology, status, rearrangement, levels STMs were collected from Wuhan...
Abstract Background The mortality rate from acute respiratory distress syndrome (ARDS) is high among hospitalized patients with coronavirus disease 2019 (COVID-19). Hence, risk evaluation tools are required to immediately identify high-risk upon admission for early intervention. Methods A cohort of 220 consecutive COVID-19 were included in this study. To analyze the factors ARDS, data obtained approximately 70% participants randomly selected and used as training dataset establish a logistic...
Multiple studies showed that metabolic disorders play a critical role in respiratory infectious diseases, including COVID-19. Metabolites contained small extracellular vesicles (sEVs) are different from those plasma at the acute stage, while features of sEVs COVID-19 survivors remain unknown. Here, we used nanopore membrane-based microfluidic chip for separation, termed ExoSEC, and compared obtained by UC, REG, ExoSEC terms time, cost, purity, features. The results indicated was much less...
Introduction This study aimed to construct artificial intelligence models based on thoracic CT images perform segmentation and classification of benign pleural effusion (BPE) malignant (MPE). Methods A total 918 patients with were initially included, 607 randomly selected cases used as the training cohort other 311 internal testing cohort; another independent external 362 was used. We developed a model (M1) by combining 3D spatially weighted U-Net 2D classical U-Net. Then, (M2) built...